node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
apt | gmk | b0469 | b3648 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. Belongs to the guanylate kinase family. | 0.952 |
apt | gpt | b0469 | b0238 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Xanthine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine. | 0.990 |
apt | gsk | b0469 | b0477 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Inosine-guanosine kinase; Protein involved in nucleobase, nucleoside and nucleotide interconversion. | 0.937 |
apt | guaA | b0469 | b2507 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | GMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP. | 0.992 |
apt | guaC | b0469 | b0104 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily. | 0.977 |
apt | hpt | b0469 | b0125 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Hypoxanthine phosphoribosyltransferase; Acts preferentially on hypoxanthine; has very low activity towards guanine. Inactive towards xanthine. Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.984 |
gmk | apt | b3648 | b0469 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. Belongs to the guanylate kinase family. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.952 |
gmk | gpt | b3648 | b0238 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. Belongs to the guanylate kinase family. | Xanthine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine. | 0.962 |
gmk | gsk | b3648 | b0477 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. Belongs to the guanylate kinase family. | Inosine-guanosine kinase; Protein involved in nucleobase, nucleoside and nucleotide interconversion. | 0.938 |
gmk | guaA | b3648 | b2507 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. Belongs to the guanylate kinase family. | GMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP. | 0.980 |
gmk | guaC | b3648 | b0104 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. Belongs to the guanylate kinase family. | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily. | 0.940 |
gmk | hpt | b3648 | b0125 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. Belongs to the guanylate kinase family. | Hypoxanthine phosphoribosyltransferase; Acts preferentially on hypoxanthine; has very low activity towards guanine. Inactive towards xanthine. Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.959 |
gmk | ndk | b3648 | b2518 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. Belongs to the guanylate kinase family. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. | 0.952 |
gmk | rpoZ | b3648 | b3649 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. Belongs to the guanylate kinase family. | RNA polymerase, omega subunit; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. | 0.980 |
gmk | spoT | b3648 | b3650 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. Belongs to the guanylate kinase family. | Bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response which coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes both the synthesis and degradation of ppGpp. The second messengers ppGpp and c-di-GMP together control biofilm formation in response to translational stress; ppGpp represses biofilm formation while c-di-GMP induces it. ppGpp activates transcription of CsrA-antagonistic s [...] | 0.966 |
gmk | tpiA | b3648 | b3919 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. Belongs to the guanylate kinase family. | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. | 0.933 |
gpt | apt | b0238 | b0469 | Xanthine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.990 |
gpt | gmk | b0238 | b3648 | Xanthine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. Belongs to the guanylate kinase family. | 0.962 |
gpt | gsk | b0238 | b0477 | Xanthine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine. | Inosine-guanosine kinase; Protein involved in nucleobase, nucleoside and nucleotide interconversion. | 0.978 |
gpt | guaA | b0238 | b2507 | Xanthine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine. | GMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP. | 0.990 |