node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
aroP | tnaA | b0112 | b3708 | Aromatic amino acid transporter; Permease that is involved in the transport across the cytoplasmic membrane of the aromatic amino acids (phenylalanine, tyrosine, and tryptophan). | tryptophanase/L-cysteine desulfhydrase, PLP-dependent; Tryptophanase; Protein involved in cellular amino acid catabolic process; Belongs to the beta-eliminating lyase family. | 0.544 |
aroP | tnaB | b0112 | b3709 | Aromatic amino acid transporter; Permease that is involved in the transport across the cytoplasmic membrane of the aromatic amino acids (phenylalanine, tyrosine, and tryptophan). | Tryptophan transporter of low affinity; Involved in tryptophan transport across the cytoplasmic membrane. Plays a role in transporting tryptophan which is to be used catabolically. | 0.877 |
aroP | trpR | b0112 | b4393 | Aromatic amino acid transporter; Permease that is involved in the transport across the cytoplasmic membrane of the aromatic amino acids (phenylalanine, tyrosine, and tryptophan). | Transcriptional repressor, tryptophan-binding; This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region. | 0.476 |
aroP | yddG | b0112 | b1473 | Aromatic amino acid transporter; Permease that is involved in the transport across the cytoplasmic membrane of the aromatic amino acids (phenylalanine, tyrosine, and tryptophan). | Aromatic amino acid exporter YddG; Probable efflux pump. Overexpression confers resistance to phenylalanine and increases export of phenylalanine, tyrosine and tryptophan; Belongs to the drug/metabolite transporter (DMT) superfamily. Aromatic amino acid/paraquat exporter (ArAA/P-E) (TC 2.A.7.17) family. | 0.731 |
dcuC | tnaB | b0621 | b3709 | Anaerobic C4-dicarboxylate transport; Responsible for the transport of C4-dicarboxylates during anaerobic growth; Belongs to the DcuC/DcuD transporter (TC 2.A.61) family. | Tryptophan transporter of low affinity; Involved in tryptophan transport across the cytoplasmic membrane. Plays a role in transporting tryptophan which is to be used catabolically. | 0.613 |
tdcC | tnaB | b3116 | b3709 | L-threonine/L-serine transporter; Involved in the import of threonine and serine into the cell, with the concomitant import of a proton (symport system). Belongs to the amino acid/polyamine transporter 2 family. SdaC/TdcC subfamily. | Tryptophan transporter of low affinity; Involved in tryptophan transport across the cytoplasmic membrane. Plays a role in transporting tryptophan which is to be used catabolically. | 0.610 |
tnaA | aroP | b3708 | b0112 | tryptophanase/L-cysteine desulfhydrase, PLP-dependent; Tryptophanase; Protein involved in cellular amino acid catabolic process; Belongs to the beta-eliminating lyase family. | Aromatic amino acid transporter; Permease that is involved in the transport across the cytoplasmic membrane of the aromatic amino acids (phenylalanine, tyrosine, and tryptophan). | 0.544 |
tnaA | tnaB | b3708 | b3709 | tryptophanase/L-cysteine desulfhydrase, PLP-dependent; Tryptophanase; Protein involved in cellular amino acid catabolic process; Belongs to the beta-eliminating lyase family. | Tryptophan transporter of low affinity; Involved in tryptophan transport across the cytoplasmic membrane. Plays a role in transporting tryptophan which is to be used catabolically. | 0.988 |
tnaA | tnaC | b3708 | b3707 | tryptophanase/L-cysteine desulfhydrase, PLP-dependent; Tryptophanase; Protein involved in cellular amino acid catabolic process; Belongs to the beta-eliminating lyase family. | Tryptophanase leader peptide; Required for tryptophan-regulated expression of the tna operon. In the presence of free L-Trp release of this nascent peptide by release factor 2 is inhibited and the ribosome stalls with the last amino acid in the P site and a UGA stop codon in the A site. This prevent transcripiton termination factor Rho binding, and thus allows transcription and translation of TnaA and TnaB. | 0.992 |
tnaA | trpA | b3708 | b1260 | tryptophanase/L-cysteine desulfhydrase, PLP-dependent; Tryptophanase; Protein involved in cellular amino acid catabolic process; Belongs to the beta-eliminating lyase family. | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate; Belongs to the TrpA family. | 0.936 |
tnaA | trpR | b3708 | b4393 | tryptophanase/L-cysteine desulfhydrase, PLP-dependent; Tryptophanase; Protein involved in cellular amino acid catabolic process; Belongs to the beta-eliminating lyase family. | Transcriptional repressor, tryptophan-binding; This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region. | 0.730 |
tnaB | aroP | b3709 | b0112 | Tryptophan transporter of low affinity; Involved in tryptophan transport across the cytoplasmic membrane. Plays a role in transporting tryptophan which is to be used catabolically. | Aromatic amino acid transporter; Permease that is involved in the transport across the cytoplasmic membrane of the aromatic amino acids (phenylalanine, tyrosine, and tryptophan). | 0.877 |
tnaB | dcuC | b3709 | b0621 | Tryptophan transporter of low affinity; Involved in tryptophan transport across the cytoplasmic membrane. Plays a role in transporting tryptophan which is to be used catabolically. | Anaerobic C4-dicarboxylate transport; Responsible for the transport of C4-dicarboxylates during anaerobic growth; Belongs to the DcuC/DcuD transporter (TC 2.A.61) family. | 0.613 |
tnaB | tdcC | b3709 | b3116 | Tryptophan transporter of low affinity; Involved in tryptophan transport across the cytoplasmic membrane. Plays a role in transporting tryptophan which is to be used catabolically. | L-threonine/L-serine transporter; Involved in the import of threonine and serine into the cell, with the concomitant import of a proton (symport system). Belongs to the amino acid/polyamine transporter 2 family. SdaC/TdcC subfamily. | 0.610 |
tnaB | tnaA | b3709 | b3708 | Tryptophan transporter of low affinity; Involved in tryptophan transport across the cytoplasmic membrane. Plays a role in transporting tryptophan which is to be used catabolically. | tryptophanase/L-cysteine desulfhydrase, PLP-dependent; Tryptophanase; Protein involved in cellular amino acid catabolic process; Belongs to the beta-eliminating lyase family. | 0.988 |
tnaB | tnaC | b3709 | b3707 | Tryptophan transporter of low affinity; Involved in tryptophan transport across the cytoplasmic membrane. Plays a role in transporting tryptophan which is to be used catabolically. | Tryptophanase leader peptide; Required for tryptophan-regulated expression of the tna operon. In the presence of free L-Trp release of this nascent peptide by release factor 2 is inhibited and the ribosome stalls with the last amino acid in the P site and a UGA stop codon in the A site. This prevent transcripiton termination factor Rho binding, and thus allows transcription and translation of TnaA and TnaB. | 0.971 |
tnaB | trpA | b3709 | b1260 | Tryptophan transporter of low affinity; Involved in tryptophan transport across the cytoplasmic membrane. Plays a role in transporting tryptophan which is to be used catabolically. | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate; Belongs to the TrpA family. | 0.819 |
tnaB | trpC | b3709 | b1262 | Tryptophan transporter of low affinity; Involved in tryptophan transport across the cytoplasmic membrane. Plays a role in transporting tryptophan which is to be used catabolically. | Indole-3-glycerolphosphate synthetase and N-(5-phosphoribosyl)anthranilate isomerase; Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway. The first reaction is catalyzed by the isomerase, coded by the TrpF domain; the second reaction is catalyzed by the synthase, coded by the TrpC domain. | 0.877 |
tnaB | trpR | b3709 | b4393 | Tryptophan transporter of low affinity; Involved in tryptophan transport across the cytoplasmic membrane. Plays a role in transporting tryptophan which is to be used catabolically. | Transcriptional repressor, tryptophan-binding; This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region. | 0.642 |
tnaB | yddG | b3709 | b1473 | Tryptophan transporter of low affinity; Involved in tryptophan transport across the cytoplasmic membrane. Plays a role in transporting tryptophan which is to be used catabolically. | Aromatic amino acid exporter YddG; Probable efflux pump. Overexpression confers resistance to phenylalanine and increases export of phenylalanine, tyrosine and tryptophan; Belongs to the drug/metabolite transporter (DMT) superfamily. Aromatic amino acid/paraquat exporter (ArAA/P-E) (TC 2.A.7.17) family. | 0.582 |