STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
zraPZn-dependent periplasmic chaperone; Binds zinc. Could be an important component of the zinc- balancing mechanism; Belongs to the ZraP family. (141 aa)    
Predicted Functional Partners:
zraS
Sensory histidine kinase in two-component regulatory system with ZraR; Member of the two-component regulatory system ZraS/ZraR. May function as a membrane-associated protein kinase that phosphorylates ZraR in response to high concentrations of zinc or lead in the medium.
 
  
 0.972
zraR
Transcriptional regulatory protein ZraR; Member of the two-component regulatory system ZraS/ZraR. When activated by ZraS it acts in conjunction with sigma-54 to regulate the expression of zraP. Positively autoregulates the expression of the zraSR operon.
 
   
 0.907
zntA
Zinc, cobalt and lead efflux system; Confers resistance to zinc, cadmium and lead. Couples the hydrolysis of ATP with the export of zinc, cadmium or lead, with highest activity when the metals are present as metal-thiolate complexes. Can also bind nickel, copper, cobalt and mercury. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
     
 0.782
glpB
Anaerobic sn-glycerol-3-phosphate dehydrogenase membrane anchor subunit; Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor; Belongs to the anaerobic G-3-P dehydrogenase subunit B family.
  
  
 0.675
zitB
Zinc efflux system; Involved in zinc efflux across the cytoplasmic membrane, thus reducing zinc accumulation in the cytoplasm and rendering bacteria more resistant to zinc. It may contribute to zinc homeostasis at low concentrations of zinc, whereas ZntA is required for growth at more toxic concentrations; Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
      
 0.623
csgF
Curli nucleation outer membrane protein; May be involved in the biogenesis of curli organelles.
  
     0.594
tehA
Potassium-tellurite ethidium and proflavin transporter; Responsible for potassium tellurite resistance when present in high copy number. Ion channel involved in potassium tellurite resistance (By similarity). Otherwise, phenotypically silent. Belongs to the tellurite-resistance/dicarboxylate transporter (TDT) family.
  
     0.593
yfeO
Putative ion channel protein.
  
     0.577
psiF
PsiF family protein; Induced by phosphate starvation; Protein involved in phosphorus metabolic process and response to starvation.
  
     0.552
ybiH
DUF1956 domain-containing tetR family putative transcriptional regulator; Regulates transcription of the cecR-ybhGFSR operon and the rhlE gene, which altogether are involved in the control of sensitivity to cefoperazone and chloramphenicol. Represses the cecR-ybhGFSR operon and activates the rhlE operon. Acts by binding to a palindromic sequence within the intergenic spacer located between these two divergently transcribed operons.
  
     0.543
Your Current Organism:
Escherichia coli K12
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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