STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
fecRAnti-sigma transmembrane signal transducer for ferric citrate transport; Regulation of iron dicitrate transport. In the absence of citrate FecR inactivates fecI. FecR is probably a sensor that recognizes iron dicitrate in the periplasm. (317 aa)    
Predicted Functional Partners:
fecI
RNA polymerase sigma-19 factor, fec operon-specific; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor regulates the fec genes for iron dicitrate transport (Probable); Belongs to the sigma-70 factor family. ECF subfamily.
 
 0.999
fecA
TonB-dependent outer membrane ferric citrate transporter and signal transducer; FecA is the outer membrane receptor protein in the Fe(3+) dicitrate transport system.
 
 
 0.998
fecB
Ferric citrate ABC transporter periplasmic binding protein; Binds citrate-dependent Fe(3+); part of the binding-protein- dependent transport system for uptake of citrate-dependent Fe(3+).
 
  
 0.960
fhuE
Ferric-rhodotorulic acid outer membrane transporter; Required for the uptake of Fe(3+) via coprogen, ferrioxamine B, and rhodotorulic acid.
 
 
 0.892
fecD
Ferric citrate ABC transporter permease; Part of the binding-protein-dependent transport system for citrate-dependent Fe(3+). Probably responsible for the translocation of the substrate across the membrane.
 
  
 0.883
fecE
Fe(3+) dicitrate transport ATP-binding protein FecE; Part of the binding-protein-dependent transport system for citrate-dependent Fe(3+). Probably responsible for energy coupling to the transport system.
  
  
 0.879
fecC
Ferric citrate ABC transporter permease; Part of the binding-protein-dependent transport system for citrate-dependent Fe(3+). Probably responsible for the translocation of the substrate across the membrane.
 
  
 0.877
exbB
Membrane spanning protein in TonB-ExbB-ExbD complex; Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates. Protects ExbD from proteolytic degradation and functionally stabilizes TonB.
   
  
 0.839
exbD
Membrane spanning protein in TonB-ExbB-ExbD complex; Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates.
   
  
 0.783
fhuA
Ferrichrome outer membrane transporter; Involved in the uptake of iron in complex with ferrichrome, a hydroxamate-type siderophore. Binds and transports ferrichrome-iron across the outer membrane. In addition to its role in ferrichrome-iron transport, transports the antibiotic albomycin, which is a structural analog of ferrichrome, and acts as a receptor for colicin M, microcin J25 and bacteriophages T1, T5, phi80 and UC-1. The energy source, which is required for all FhuA functions except infection by phage T5, is provided by the inner membrane TonB system.
 
  
 0.755
Your Current Organism:
Escherichia coli K12
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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