node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
dinJ | lexA | b0226 | b4043 | Antitoxin of YafQ-DinJ toxin-antitoxin system; Antitoxin component of a type II toxin-antitoxin (TA) system. A labile antitoxin that counteracts the effect of cognate toxin YafQ. YafQ and DinJ together bind their own promoter, and repress its expression. There are 2 operators with imperfect inverted repeats (IR) in the dinJ promoter, YafQ-(DinJ)2-YafQ only binds to the first (most upstream) of them to repress transcription; binding to a single IR is sufficient for activity in vivo and in vitro. DinJ alone is as potent a transcriptional repressor as the heterotetramer and also only need [...] | Transcriptional repressor of SOS regulon; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Binds to the 16 bp palindromic sequence 5'-CTGTATATATATACAG-3'. In the presence of single- stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. Implicated in hydroxy radical-mediated cell death induced by hydroxyurea treatment .The SOS response controls an apoptotic-like death (ALD) induced (in the absence [...] | 0.529 |
dinJ | mazE | b0226 | b2783 | Antitoxin of YafQ-DinJ toxin-antitoxin system; Antitoxin component of a type II toxin-antitoxin (TA) system. A labile antitoxin that counteracts the effect of cognate toxin YafQ. YafQ and DinJ together bind their own promoter, and repress its expression. There are 2 operators with imperfect inverted repeats (IR) in the dinJ promoter, YafQ-(DinJ)2-YafQ only binds to the first (most upstream) of them to repress transcription; binding to a single IR is sufficient for activity in vivo and in vitro. DinJ alone is as potent a transcriptional repressor as the heterotetramer and also only need [...] | Antitoxin of the ChpA-ChpR toxin-antitoxin system; Antitoxin component of a type II toxin-antitoxin (TA) system. Labile antitoxin that binds to the MazF endoribonuclease toxin and neutralizes its endoribonuclease activity. Is considered to be an 'addiction' molecule as the cell dies in its absence. Toxicity results when the levels of MazE decrease in the cell, leading to mRNA degradation. This effect can be rescued by expression of MazE, but after 6 hours in rich medium the overexpression of MazF leads to programmed cell death. Cell growth and viability are not affected when MazF and M [...] | 0.961 |
dinJ | symE | b0226 | b4347 | Antitoxin of YafQ-DinJ toxin-antitoxin system; Antitoxin component of a type II toxin-antitoxin (TA) system. A labile antitoxin that counteracts the effect of cognate toxin YafQ. YafQ and DinJ together bind their own promoter, and repress its expression. There are 2 operators with imperfect inverted repeats (IR) in the dinJ promoter, YafQ-(DinJ)2-YafQ only binds to the first (most upstream) of them to repress transcription; binding to a single IR is sufficient for activity in vivo and in vitro. DinJ alone is as potent a transcriptional repressor as the heterotetramer and also only need [...] | Toxic peptide regulated by antisense sRNA symR; Toxic component of a type I toxin-antitoxin (TA) system. Involved in the degradation and recycling of damaged RNA. It is itself a target for degradation by the ATP-dependent protease Lon. Belongs to the SymE family. | 0.624 |
dinJ | tisB | b0226 | b4618 | Antitoxin of YafQ-DinJ toxin-antitoxin system; Antitoxin component of a type II toxin-antitoxin (TA) system. A labile antitoxin that counteracts the effect of cognate toxin YafQ. YafQ and DinJ together bind their own promoter, and repress its expression. There are 2 operators with imperfect inverted repeats (IR) in the dinJ promoter, YafQ-(DinJ)2-YafQ only binds to the first (most upstream) of them to repress transcription; binding to a single IR is sufficient for activity in vivo and in vitro. DinJ alone is as potent a transcriptional repressor as the heterotetramer and also only need [...] | Toxic membrane persister formation peptide, LexA-regulated; Toxic component of a type I toxin-antitoxin (TA) system (Probable). Overexpression causes cessation of growth, induces stress-response, a number of membrane protein genes, and leads to cell death. Inhibits ATP synthesis, ATP levels drop drastically quickly after induction. Part of the programmed response to DNA damage; damage leads to increased accumulation of the protein which slows or stops bacterial growth, probably allowing DNA repair before cells continue to grow. | 0.544 |
dinQ | ibsC | b4613 | b4665 | UV-inducible membrane toxin, DinQ-AgrB type I toxin-antitoxin system; Belongs to the DinQ family. | Toxic membrane protein. | 0.806 |
dinQ | ldrD | b4613 | b4453 | UV-inducible membrane toxin, DinQ-AgrB type I toxin-antitoxin system; Belongs to the DinQ family. | Toxic polypeptide, small; Toxic component of a type I toxin-antitoxin (TA) system. Overexpression causes rapid cell killing and nucleoid condensation of the host cell. Overexpression induces stress-response and a number of membrane protein genes. May inhibit ATP synthesis due to its insertion in the cell inner membrane (By similarity). | 0.817 |
dinQ | ralR | b4613 | b1348 | UV-inducible membrane toxin, DinQ-AgrB type I toxin-antitoxin system; Belongs to the DinQ family. | Rac prophage; Toxic component of a type I toxin-antitoxin (TA) system. Upon overexpression inhibits growth and reduces colony-forming units in both the presence and absence of the Rac prophage, cells become filamentous. Has deoxyribonuclease activity (probably endonucleolytic), does not digest RNA. Its toxic effects are neutralized by sRNA antitoxin RalA, which is encoded in trans on the opposite DNA strand. Has RAL-like activity. | 0.809 |
dinQ | ratA | b4613 | b2619 | UV-inducible membrane toxin, DinQ-AgrB type I toxin-antitoxin system; Belongs to the DinQ family. | Toxic UPF0083 family protein inhibitor of 70S ribosome formation; Toxic component of a type II toxin-antitoxin (TA) system. Binds to 50S ribosomal subunits, preventing them from associating with 30S subunits to form 70S ribosomes and reducing polysomes. It does not cause ribosomes to dissociate however. The antibiotic paromomycin blocks the anti-association activity of RatA. Overexpression results in inhibition of growth in liquid cultures, and in a decrease in protein translation. The other gene of this operon, ratB, is not the cognate antitoxin in this strain; in CFT073 however it do [...] | 0.623 |
dinQ | shoB | b4613 | b4687 | UV-inducible membrane toxin, DinQ-AgrB type I toxin-antitoxin system; Belongs to the DinQ family. | Toxic membrane protein; Toxic component of a type I toxin-antitoxin (TA) system. May be a toxic protein; overexpression causes cessation of growth and rapid membrane depolarization. Overexpression induces stress-response and a number of membrane protein genes. | 0.897 |
dinQ | symE | b4613 | b4347 | UV-inducible membrane toxin, DinQ-AgrB type I toxin-antitoxin system; Belongs to the DinQ family. | Toxic peptide regulated by antisense sRNA symR; Toxic component of a type I toxin-antitoxin (TA) system. Involved in the degradation and recycling of damaged RNA. It is itself a target for degradation by the ATP-dependent protease Lon. Belongs to the SymE family. | 0.818 |
dinQ | tisB | b4613 | b4618 | UV-inducible membrane toxin, DinQ-AgrB type I toxin-antitoxin system; Belongs to the DinQ family. | Toxic membrane persister formation peptide, LexA-regulated; Toxic component of a type I toxin-antitoxin (TA) system (Probable). Overexpression causes cessation of growth, induces stress-response, a number of membrane protein genes, and leads to cell death. Inhibits ATP synthesis, ATP levels drop drastically quickly after induction. Part of the programmed response to DNA damage; damage leads to increased accumulation of the protein which slows or stops bacterial growth, probably allowing DNA repair before cells continue to grow. | 0.900 |
ibsC | dinQ | b4665 | b4613 | Toxic membrane protein. | UV-inducible membrane toxin, DinQ-AgrB type I toxin-antitoxin system; Belongs to the DinQ family. | 0.806 |
ibsC | ldrD | b4665 | b4453 | Toxic membrane protein. | Toxic polypeptide, small; Toxic component of a type I toxin-antitoxin (TA) system. Overexpression causes rapid cell killing and nucleoid condensation of the host cell. Overexpression induces stress-response and a number of membrane protein genes. May inhibit ATP synthesis due to its insertion in the cell inner membrane (By similarity). | 0.892 |
ibsC | shoB | b4665 | b4687 | Toxic membrane protein. | Toxic membrane protein; Toxic component of a type I toxin-antitoxin (TA) system. May be a toxic protein; overexpression causes cessation of growth and rapid membrane depolarization. Overexpression induces stress-response and a number of membrane protein genes. | 0.891 |
ibsC | symE | b4665 | b4347 | Toxic membrane protein. | Toxic peptide regulated by antisense sRNA symR; Toxic component of a type I toxin-antitoxin (TA) system. Involved in the degradation and recycling of damaged RNA. It is itself a target for degradation by the ATP-dependent protease Lon. Belongs to the SymE family. | 0.622 |
ibsC | tisB | b4665 | b4618 | Toxic membrane protein. | Toxic membrane persister formation peptide, LexA-regulated; Toxic component of a type I toxin-antitoxin (TA) system (Probable). Overexpression causes cessation of growth, induces stress-response, a number of membrane protein genes, and leads to cell death. Inhibits ATP synthesis, ATP levels drop drastically quickly after induction. Part of the programmed response to DNA damage; damage leads to increased accumulation of the protein which slows or stops bacterial growth, probably allowing DNA repair before cells continue to grow. | 0.810 |
ldrD | dinQ | b4453 | b4613 | Toxic polypeptide, small; Toxic component of a type I toxin-antitoxin (TA) system. Overexpression causes rapid cell killing and nucleoid condensation of the host cell. Overexpression induces stress-response and a number of membrane protein genes. May inhibit ATP synthesis due to its insertion in the cell inner membrane (By similarity). | UV-inducible membrane toxin, DinQ-AgrB type I toxin-antitoxin system; Belongs to the DinQ family. | 0.817 |
ldrD | ibsC | b4453 | b4665 | Toxic polypeptide, small; Toxic component of a type I toxin-antitoxin (TA) system. Overexpression causes rapid cell killing and nucleoid condensation of the host cell. Overexpression induces stress-response and a number of membrane protein genes. May inhibit ATP synthesis due to its insertion in the cell inner membrane (By similarity). | Toxic membrane protein. | 0.892 |
ldrD | ralR | b4453 | b1348 | Toxic polypeptide, small; Toxic component of a type I toxin-antitoxin (TA) system. Overexpression causes rapid cell killing and nucleoid condensation of the host cell. Overexpression induces stress-response and a number of membrane protein genes. May inhibit ATP synthesis due to its insertion in the cell inner membrane (By similarity). | Rac prophage; Toxic component of a type I toxin-antitoxin (TA) system. Upon overexpression inhibits growth and reduces colony-forming units in both the presence and absence of the Rac prophage, cells become filamentous. Has deoxyribonuclease activity (probably endonucleolytic), does not digest RNA. Its toxic effects are neutralized by sRNA antitoxin RalA, which is encoded in trans on the opposite DNA strand. Has RAL-like activity. | 0.623 |
ldrD | shoB | b4453 | b4687 | Toxic polypeptide, small; Toxic component of a type I toxin-antitoxin (TA) system. Overexpression causes rapid cell killing and nucleoid condensation of the host cell. Overexpression induces stress-response and a number of membrane protein genes. May inhibit ATP synthesis due to its insertion in the cell inner membrane (By similarity). | Toxic membrane protein; Toxic component of a type I toxin-antitoxin (TA) system. May be a toxic protein; overexpression causes cessation of growth and rapid membrane depolarization. Overexpression induces stress-response and a number of membrane protein genes. | 0.892 |