node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
secA | yjiY | b0098 | b4354 | Preprotein translocase subunit, ATPase; Required for protein export, interacts with the SecYEG preprotein conducting channel. SecA has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. | Putative transporter; Transports pyruvate with a high affinity and specificity. The process is driven by the proton motive force. Part of a nutrient-sensing regulatory network composed of the two-component regulatory systems BtsS/BtsR and YpdA/YpdB, and their respective target proteins, BtsT and YhjX. Belongs to the peptide transporter carbon starvation (CstA) (TC 2.A.114) family. | 0.645 |
ybdD | yehT | b4512 | b2125 | DUF466 family protein; To E.coli YjiX. | Putative response regulator in two-component system withYehU; Member of the two-component regulatory system BtsS/BtsR, which is part of a nutrient-sensing regulatory network composed of BtsS/BtsR, the low-affinity pyruvate signaling system YpdA/YpdB and their respective target proteins, BtsT and YhjX. Responds to depletion of nutrients, specifically serine, and the concomitant presence of extracellular pyruvate. BtsR regulates expression of btsT by binding to its promoter region. Activation of the BtsS/BtsR signaling cascade also suppresses YpdA/YpdB-mediated yhjX induction. | 0.407 |
ybdD | yehU | b4512 | b2126 | DUF466 family protein; To E.coli YjiX. | Inner membrane putative sensory kinase in two-component system with YehT; Member of the two-component regulatory system BtsS/BtsR, which is part of a nutrient-sensing regulatory network composed of BtsS/BtsR, the low-affinity pyruvate signaling system YpdA/YpdB and their respective target proteins, BtsT and YhjX. Responds to depletion of nutrients, specifically serine, and the concomitant presence of extracellular pyruvate. BtsS is a high-affinity receptor for extracellular pyruvate that activates BtsR by phosphorylation. Activation of the BtsS/BtsR signaling cascade also suppresses Yp [...] | 0.502 |
ybdD | yhjX | b4512 | b3547 | DUF466 family protein; To E.coli YjiX. | Pyruvate-inducible inner membrane protein, putative transporter; Part of a nutrient-sensing regulatory network composed of the two-component regulatory systems BtsS/BtsR and YpdA/YpdB, and their respective target proteins, BtsT and YhjX. Belongs to the major facilitator superfamily. | 0.412 |
ybdD | yjiY | b4512 | b4354 | DUF466 family protein; To E.coli YjiX. | Putative transporter; Transports pyruvate with a high affinity and specificity. The process is driven by the proton motive force. Part of a nutrient-sensing regulatory network composed of the two-component regulatory systems BtsS/BtsR and YpdA/YpdB, and their respective target proteins, BtsT and YhjX. Belongs to the peptide transporter carbon starvation (CstA) (TC 2.A.114) family. | 0.908 |
ybdD | ypdA | b4512 | b2380 | DUF466 family protein; To E.coli YjiX. | Sensor kinase regulating yhjX; Member of the two-component regulatory system YpdA/YpdB, which is part of a nutrient-sensing regulatory network composed of YpdA/YpdB, the high-affinity pyruvate signaling system BtsS/BtsR and their respective target proteins, YhjX and BtsT. YpdA activates YpdB by phosphorylation in response to high concentrations of extracellular pyruvate. Activation of the YpdA/YpdB signaling cascade also promotes BtsS/BtsR-mediated btsT expression. | 0.532 |
ybdD | ypdB | b4512 | b2381 | DUF466 family protein; To E.coli YjiX. | Response regulator activating yhjX; Member of the two-component regulatory system YpdA/YpdB, which is part of a nutrient-sensing regulatory network composed of YpdA/YpdB, the high-affinity pyruvate signaling system BtsS/BtsR and their respective target proteins, YhjX and BtsT. YpdB regulates expression of yhjX by binding to its promoter region. Activation of the YpdA/YpdB signaling cascade also promotes BtsS/BtsR-mediated btsT expression. | 0.533 |
ydgA | yjiY | b1614 | b4354 | DUF945 family protein. | Putative transporter; Transports pyruvate with a high affinity and specificity. The process is driven by the proton motive force. Part of a nutrient-sensing regulatory network composed of the two-component regulatory systems BtsS/BtsR and YpdA/YpdB, and their respective target proteins, BtsT and YhjX. Belongs to the peptide transporter carbon starvation (CstA) (TC 2.A.114) family. | 0.645 |
yehT | ybdD | b2125 | b4512 | Putative response regulator in two-component system withYehU; Member of the two-component regulatory system BtsS/BtsR, which is part of a nutrient-sensing regulatory network composed of BtsS/BtsR, the low-affinity pyruvate signaling system YpdA/YpdB and their respective target proteins, BtsT and YhjX. Responds to depletion of nutrients, specifically serine, and the concomitant presence of extracellular pyruvate. BtsR regulates expression of btsT by binding to its promoter region. Activation of the BtsS/BtsR signaling cascade also suppresses YpdA/YpdB-mediated yhjX induction. | DUF466 family protein; To E.coli YjiX. | 0.407 |
yehT | yehU | b2125 | b2126 | Putative response regulator in two-component system withYehU; Member of the two-component regulatory system BtsS/BtsR, which is part of a nutrient-sensing regulatory network composed of BtsS/BtsR, the low-affinity pyruvate signaling system YpdA/YpdB and their respective target proteins, BtsT and YhjX. Responds to depletion of nutrients, specifically serine, and the concomitant presence of extracellular pyruvate. BtsR regulates expression of btsT by binding to its promoter region. Activation of the BtsS/BtsR signaling cascade also suppresses YpdA/YpdB-mediated yhjX induction. | Inner membrane putative sensory kinase in two-component system with YehT; Member of the two-component regulatory system BtsS/BtsR, which is part of a nutrient-sensing regulatory network composed of BtsS/BtsR, the low-affinity pyruvate signaling system YpdA/YpdB and their respective target proteins, BtsT and YhjX. Responds to depletion of nutrients, specifically serine, and the concomitant presence of extracellular pyruvate. BtsS is a high-affinity receptor for extracellular pyruvate that activates BtsR by phosphorylation. Activation of the BtsS/BtsR signaling cascade also suppresses Yp [...] | 0.999 |
yehT | yhjX | b2125 | b3547 | Putative response regulator in two-component system withYehU; Member of the two-component regulatory system BtsS/BtsR, which is part of a nutrient-sensing regulatory network composed of BtsS/BtsR, the low-affinity pyruvate signaling system YpdA/YpdB and their respective target proteins, BtsT and YhjX. Responds to depletion of nutrients, specifically serine, and the concomitant presence of extracellular pyruvate. BtsR regulates expression of btsT by binding to its promoter region. Activation of the BtsS/BtsR signaling cascade also suppresses YpdA/YpdB-mediated yhjX induction. | Pyruvate-inducible inner membrane protein, putative transporter; Part of a nutrient-sensing regulatory network composed of the two-component regulatory systems BtsS/BtsR and YpdA/YpdB, and their respective target proteins, BtsT and YhjX. Belongs to the major facilitator superfamily. | 0.812 |
yehT | yjiY | b2125 | b4354 | Putative response regulator in two-component system withYehU; Member of the two-component regulatory system BtsS/BtsR, which is part of a nutrient-sensing regulatory network composed of BtsS/BtsR, the low-affinity pyruvate signaling system YpdA/YpdB and their respective target proteins, BtsT and YhjX. Responds to depletion of nutrients, specifically serine, and the concomitant presence of extracellular pyruvate. BtsR regulates expression of btsT by binding to its promoter region. Activation of the BtsS/BtsR signaling cascade also suppresses YpdA/YpdB-mediated yhjX induction. | Putative transporter; Transports pyruvate with a high affinity and specificity. The process is driven by the proton motive force. Part of a nutrient-sensing regulatory network composed of the two-component regulatory systems BtsS/BtsR and YpdA/YpdB, and their respective target proteins, BtsT and YhjX. Belongs to the peptide transporter carbon starvation (CstA) (TC 2.A.114) family. | 0.894 |
yehT | ypdA | b2125 | b2380 | Putative response regulator in two-component system withYehU; Member of the two-component regulatory system BtsS/BtsR, which is part of a nutrient-sensing regulatory network composed of BtsS/BtsR, the low-affinity pyruvate signaling system YpdA/YpdB and their respective target proteins, BtsT and YhjX. Responds to depletion of nutrients, specifically serine, and the concomitant presence of extracellular pyruvate. BtsR regulates expression of btsT by binding to its promoter region. Activation of the BtsS/BtsR signaling cascade also suppresses YpdA/YpdB-mediated yhjX induction. | Sensor kinase regulating yhjX; Member of the two-component regulatory system YpdA/YpdB, which is part of a nutrient-sensing regulatory network composed of YpdA/YpdB, the high-affinity pyruvate signaling system BtsS/BtsR and their respective target proteins, YhjX and BtsT. YpdA activates YpdB by phosphorylation in response to high concentrations of extracellular pyruvate. Activation of the YpdA/YpdB signaling cascade also promotes BtsS/BtsR-mediated btsT expression. | 0.973 |
yehT | ypdB | b2125 | b2381 | Putative response regulator in two-component system withYehU; Member of the two-component regulatory system BtsS/BtsR, which is part of a nutrient-sensing regulatory network composed of BtsS/BtsR, the low-affinity pyruvate signaling system YpdA/YpdB and their respective target proteins, BtsT and YhjX. Responds to depletion of nutrients, specifically serine, and the concomitant presence of extracellular pyruvate. BtsR regulates expression of btsT by binding to its promoter region. Activation of the BtsS/BtsR signaling cascade also suppresses YpdA/YpdB-mediated yhjX induction. | Response regulator activating yhjX; Member of the two-component regulatory system YpdA/YpdB, which is part of a nutrient-sensing regulatory network composed of YpdA/YpdB, the high-affinity pyruvate signaling system BtsS/BtsR and their respective target proteins, YhjX and BtsT. YpdB regulates expression of yhjX by binding to its promoter region. Activation of the YpdA/YpdB signaling cascade also promotes BtsS/BtsR-mediated btsT expression. | 0.414 |
yehU | ybdD | b2126 | b4512 | Inner membrane putative sensory kinase in two-component system with YehT; Member of the two-component regulatory system BtsS/BtsR, which is part of a nutrient-sensing regulatory network composed of BtsS/BtsR, the low-affinity pyruvate signaling system YpdA/YpdB and their respective target proteins, BtsT and YhjX. Responds to depletion of nutrients, specifically serine, and the concomitant presence of extracellular pyruvate. BtsS is a high-affinity receptor for extracellular pyruvate that activates BtsR by phosphorylation. Activation of the BtsS/BtsR signaling cascade also suppresses Yp [...] | DUF466 family protein; To E.coli YjiX. | 0.502 |
yehU | yehT | b2126 | b2125 | Inner membrane putative sensory kinase in two-component system with YehT; Member of the two-component regulatory system BtsS/BtsR, which is part of a nutrient-sensing regulatory network composed of BtsS/BtsR, the low-affinity pyruvate signaling system YpdA/YpdB and their respective target proteins, BtsT and YhjX. Responds to depletion of nutrients, specifically serine, and the concomitant presence of extracellular pyruvate. BtsS is a high-affinity receptor for extracellular pyruvate that activates BtsR by phosphorylation. Activation of the BtsS/BtsR signaling cascade also suppresses Yp [...] | Putative response regulator in two-component system withYehU; Member of the two-component regulatory system BtsS/BtsR, which is part of a nutrient-sensing regulatory network composed of BtsS/BtsR, the low-affinity pyruvate signaling system YpdA/YpdB and their respective target proteins, BtsT and YhjX. Responds to depletion of nutrients, specifically serine, and the concomitant presence of extracellular pyruvate. BtsR regulates expression of btsT by binding to its promoter region. Activation of the BtsS/BtsR signaling cascade also suppresses YpdA/YpdB-mediated yhjX induction. | 0.999 |
yehU | yhjX | b2126 | b3547 | Inner membrane putative sensory kinase in two-component system with YehT; Member of the two-component regulatory system BtsS/BtsR, which is part of a nutrient-sensing regulatory network composed of BtsS/BtsR, the low-affinity pyruvate signaling system YpdA/YpdB and their respective target proteins, BtsT and YhjX. Responds to depletion of nutrients, specifically serine, and the concomitant presence of extracellular pyruvate. BtsS is a high-affinity receptor for extracellular pyruvate that activates BtsR by phosphorylation. Activation of the BtsS/BtsR signaling cascade also suppresses Yp [...] | Pyruvate-inducible inner membrane protein, putative transporter; Part of a nutrient-sensing regulatory network composed of the two-component regulatory systems BtsS/BtsR and YpdA/YpdB, and their respective target proteins, BtsT and YhjX. Belongs to the major facilitator superfamily. | 0.847 |
yehU | yjiY | b2126 | b4354 | Inner membrane putative sensory kinase in two-component system with YehT; Member of the two-component regulatory system BtsS/BtsR, which is part of a nutrient-sensing regulatory network composed of BtsS/BtsR, the low-affinity pyruvate signaling system YpdA/YpdB and their respective target proteins, BtsT and YhjX. Responds to depletion of nutrients, specifically serine, and the concomitant presence of extracellular pyruvate. BtsS is a high-affinity receptor for extracellular pyruvate that activates BtsR by phosphorylation. Activation of the BtsS/BtsR signaling cascade also suppresses Yp [...] | Putative transporter; Transports pyruvate with a high affinity and specificity. The process is driven by the proton motive force. Part of a nutrient-sensing regulatory network composed of the two-component regulatory systems BtsS/BtsR and YpdA/YpdB, and their respective target proteins, BtsT and YhjX. Belongs to the peptide transporter carbon starvation (CstA) (TC 2.A.114) family. | 0.914 |
yehU | ypdA | b2126 | b2380 | Inner membrane putative sensory kinase in two-component system with YehT; Member of the two-component regulatory system BtsS/BtsR, which is part of a nutrient-sensing regulatory network composed of BtsS/BtsR, the low-affinity pyruvate signaling system YpdA/YpdB and their respective target proteins, BtsT and YhjX. Responds to depletion of nutrients, specifically serine, and the concomitant presence of extracellular pyruvate. BtsS is a high-affinity receptor for extracellular pyruvate that activates BtsR by phosphorylation. Activation of the BtsS/BtsR signaling cascade also suppresses Yp [...] | Sensor kinase regulating yhjX; Member of the two-component regulatory system YpdA/YpdB, which is part of a nutrient-sensing regulatory network composed of YpdA/YpdB, the high-affinity pyruvate signaling system BtsS/BtsR and their respective target proteins, YhjX and BtsT. YpdA activates YpdB by phosphorylation in response to high concentrations of extracellular pyruvate. Activation of the YpdA/YpdB signaling cascade also promotes BtsS/BtsR-mediated btsT expression. | 0.470 |
yehU | ypdB | b2126 | b2381 | Inner membrane putative sensory kinase in two-component system with YehT; Member of the two-component regulatory system BtsS/BtsR, which is part of a nutrient-sensing regulatory network composed of BtsS/BtsR, the low-affinity pyruvate signaling system YpdA/YpdB and their respective target proteins, BtsT and YhjX. Responds to depletion of nutrients, specifically serine, and the concomitant presence of extracellular pyruvate. BtsS is a high-affinity receptor for extracellular pyruvate that activates BtsR by phosphorylation. Activation of the BtsS/BtsR signaling cascade also suppresses Yp [...] | Response regulator activating yhjX; Member of the two-component regulatory system YpdA/YpdB, which is part of a nutrient-sensing regulatory network composed of YpdA/YpdB, the high-affinity pyruvate signaling system BtsS/BtsR and their respective target proteins, YhjX and BtsT. YpdB regulates expression of yhjX by binding to its promoter region. Activation of the YpdA/YpdB signaling cascade also promotes BtsS/BtsR-mediated btsT expression. | 0.978 |