STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
osmYSalt-inducible putative ABC transporter periplasmic binding protein; Hyperosmotically inducible periplasmic protein; Protein involved in response to osmotic stress. (201 aa)    
Predicted Functional Partners:
yjbJ
Stress-induced protein, UPF0337 family; Belongs to the UPF0337 (CsbD) family.
 
  
 0.966
ybaY
Outer membrane lipoprotein; Glycoprotein/polysaccharide metabolism; Protein involved in lipoprotein biosynthetic process and glycoprotein biosynthetic process.
  
  
 0.947
ytjA
Uncharacterized protein.
  
  
 0.947
osmC
Lipoyl-dependent Cys-based peroxidase, hydroperoxide resistance; Preferentially metabolizes organic hydroperoxides over inorganic hydrogen peroxide; Belongs to the OsmC/Ohr family.
   
  
 0.905
ygaU
Uncharacterized protein; Highly specific potassium binding protein that is required for normal growth in the presence of high levels of external K(+). May act as a sensor of cytoplasmic K(+) concentration. Binds a single K(+) ion, which induces a large conformational change. Can also bind the larger alkali metal ions Rb(+) and Cs(+), and NH(4)(+). May be involved in the regulation of peptidoglycan cross-linking.
  
  
 0.901
osmE
Osmotically-inducible lipoprotein; Activator of ntrL gene; Protein involved in transcription activator activity, transcription and response to osmotic stress.
   
  
 0.893
otsA
Trehalose-6-phosphate synthase; Catalyzes the transfer of glucose from UDP-alpha-D-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6- phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor. Essential for viability of the cells at low temperatures and at elevated osmotic strength. Belongs to the glycosyltransferase 20 family.
   
  
 0.883
yqjD
Membrane-anchored ribosome-binding protein; Upon overexpression inhibits growth.
  
  
 0.882
katE
Catalase HPII, heme d-containing; Decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide.
   
  
 0.871
rpoS
RNA polymerase, sigma S (sigma 38) factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response. Controls, positively or negatively, the expression of several hundred genes, which are mainly involved in metabolism, transport, regulation and stress management.
   
  
 0.852
Your Current Organism:
Escherichia coli K12
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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