node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
arfB | rof | b0191 | b0189 | Alternative stalled-ribosome rescue factor B; Rescues stalled ribosomes. Can hydrolyze peptidyl-tRNA on ribosomes stalled by both non-stop mRNAs and mRNAs that contain rare codon clusters or ribosomes stalled in the middle of mRNA. First identified as a complementary ribosome rescue system when the stalled ribosome cannot be rescued by the SsrA(tmRNA)- SmpB quality control system or the alternative ribosome-rescue factor A (arfA). | Modulator of Rho-dependent transcription termination; Suppresses temperature-sensitive mutations in essential genes by modulating rho-dependent transcription termination. | 0.549 |
arfB | yaeP | b0191 | b4406 | Alternative stalled-ribosome rescue factor B; Rescues stalled ribosomes. Can hydrolyze peptidyl-tRNA on ribosomes stalled by both non-stop mRNAs and mRNAs that contain rare codon clusters or ribosomes stalled in the middle of mRNA. First identified as a complementary ribosome rescue system when the stalled ribosome cannot be rescued by the SsrA(tmRNA)- SmpB quality control system or the alternative ribosome-rescue factor A (arfA). | UPF0253 family protein; Belongs to the UPF0253 family. | 0.515 |
arfB | yaeQ | b0191 | b0190 | Alternative stalled-ribosome rescue factor B; Rescues stalled ribosomes. Can hydrolyze peptidyl-tRNA on ribosomes stalled by both non-stop mRNAs and mRNAs that contain rare codon clusters or ribosomes stalled in the middle of mRNA. First identified as a complementary ribosome rescue system when the stalled ribosome cannot be rescued by the SsrA(tmRNA)- SmpB quality control system or the alternative ribosome-rescue factor A (arfA). | PDDEXK superfamily protein. | 0.849 |
fecC | yaeP | b4289 | b4406 | Ferric citrate ABC transporter permease; Part of the binding-protein-dependent transport system for citrate-dependent Fe(3+). Probably responsible for the translocation of the substrate across the membrane. | UPF0253 family protein; Belongs to the UPF0253 family. | 0.505 |
nadR | thiS | b4390 | b4407 | Trifunctional NAD biosynthesis/regulator protein NadR; This enzyme has three activities: DNA binding, nicotinamide mononucleotide (NMN) adenylyltransferase and ribosylnicotinamide (RN) kinase. The DNA-binding domain binds to the nadB operator sequence in an NAD- and ATP-dependent manner. As NAD levels increase within the cell, the affinity of NadR for the nadB operator regions of nadA, nadB, and pncB increases, repressing the transcription of these genes. The RN kinase activity catalyzes the phosphorylation of RN to form nicotinamide ribonucleotide. The NMN adenylyltransferase activity [...] | Immediate sulfur donor in thiazole formation; Is the sulfur donor in the synthesis of the thiazole phosphate moiety of thiamine phosphate. | 0.560 |
nadR | yaeP | b4390 | b4406 | Trifunctional NAD biosynthesis/regulator protein NadR; This enzyme has three activities: DNA binding, nicotinamide mononucleotide (NMN) adenylyltransferase and ribosylnicotinamide (RN) kinase. The DNA-binding domain binds to the nadB operator sequence in an NAD- and ATP-dependent manner. As NAD levels increase within the cell, the affinity of NadR for the nadB operator regions of nadA, nadB, and pncB increases, repressing the transcription of these genes. The RN kinase activity catalyzes the phosphorylation of RN to form nicotinamide ribonucleotide. The NMN adenylyltransferase activity [...] | UPF0253 family protein; Belongs to the UPF0253 family. | 0.557 |
nadR | yjjI | b4390 | b4380 | Trifunctional NAD biosynthesis/regulator protein NadR; This enzyme has three activities: DNA binding, nicotinamide mononucleotide (NMN) adenylyltransferase and ribosylnicotinamide (RN) kinase. The DNA-binding domain binds to the nadB operator sequence in an NAD- and ATP-dependent manner. As NAD levels increase within the cell, the affinity of NadR for the nadB operator regions of nadA, nadB, and pncB increases, repressing the transcription of these genes. The RN kinase activity catalyzes the phosphorylation of RN to form nicotinamide ribonucleotide. The NMN adenylyltransferase activity [...] | DUF3029 family protein, putative glycine radical enzyme. | 0.477 |
rof | arfB | b0189 | b0191 | Modulator of Rho-dependent transcription termination; Suppresses temperature-sensitive mutations in essential genes by modulating rho-dependent transcription termination. | Alternative stalled-ribosome rescue factor B; Rescues stalled ribosomes. Can hydrolyze peptidyl-tRNA on ribosomes stalled by both non-stop mRNAs and mRNAs that contain rare codon clusters or ribosomes stalled in the middle of mRNA. First identified as a complementary ribosome rescue system when the stalled ribosome cannot be rescued by the SsrA(tmRNA)- SmpB quality control system or the alternative ribosome-rescue factor A (arfA). | 0.549 |
rof | yaeP | b0189 | b4406 | Modulator of Rho-dependent transcription termination; Suppresses temperature-sensitive mutations in essential genes by modulating rho-dependent transcription termination. | UPF0253 family protein; Belongs to the UPF0253 family. | 0.931 |
rof | yaeQ | b0189 | b0190 | Modulator of Rho-dependent transcription termination; Suppresses temperature-sensitive mutations in essential genes by modulating rho-dependent transcription termination. | PDDEXK superfamily protein. | 0.516 |
rof | yjjI | b0189 | b4380 | Modulator of Rho-dependent transcription termination; Suppresses temperature-sensitive mutations in essential genes by modulating rho-dependent transcription termination. | DUF3029 family protein, putative glycine radical enzyme. | 0.519 |
rof | yjjW | b0189 | b4379 | Modulator of Rho-dependent transcription termination; Suppresses temperature-sensitive mutations in essential genes by modulating rho-dependent transcription termination. | Putative activating enzyme; Protein involved in anaerobic respiration and protein modification process; Belongs to the organic radical-activating enzymes family. | 0.547 |
thiS | nadR | b4407 | b4390 | Immediate sulfur donor in thiazole formation; Is the sulfur donor in the synthesis of the thiazole phosphate moiety of thiamine phosphate. | Trifunctional NAD biosynthesis/regulator protein NadR; This enzyme has three activities: DNA binding, nicotinamide mononucleotide (NMN) adenylyltransferase and ribosylnicotinamide (RN) kinase. The DNA-binding domain binds to the nadB operator sequence in an NAD- and ATP-dependent manner. As NAD levels increase within the cell, the affinity of NadR for the nadB operator regions of nadA, nadB, and pncB increases, repressing the transcription of these genes. The RN kinase activity catalyzes the phosphorylation of RN to form nicotinamide ribonucleotide. The NMN adenylyltransferase activity [...] | 0.560 |
thiS | yaeP | b4407 | b4406 | Immediate sulfur donor in thiazole formation; Is the sulfur donor in the synthesis of the thiazole phosphate moiety of thiamine phosphate. | UPF0253 family protein; Belongs to the UPF0253 family. | 0.811 |
yaeP | arfB | b4406 | b0191 | UPF0253 family protein; Belongs to the UPF0253 family. | Alternative stalled-ribosome rescue factor B; Rescues stalled ribosomes. Can hydrolyze peptidyl-tRNA on ribosomes stalled by both non-stop mRNAs and mRNAs that contain rare codon clusters or ribosomes stalled in the middle of mRNA. First identified as a complementary ribosome rescue system when the stalled ribosome cannot be rescued by the SsrA(tmRNA)- SmpB quality control system or the alternative ribosome-rescue factor A (arfA). | 0.515 |
yaeP | fecC | b4406 | b4289 | UPF0253 family protein; Belongs to the UPF0253 family. | Ferric citrate ABC transporter permease; Part of the binding-protein-dependent transport system for citrate-dependent Fe(3+). Probably responsible for the translocation of the substrate across the membrane. | 0.505 |
yaeP | nadR | b4406 | b4390 | UPF0253 family protein; Belongs to the UPF0253 family. | Trifunctional NAD biosynthesis/regulator protein NadR; This enzyme has three activities: DNA binding, nicotinamide mononucleotide (NMN) adenylyltransferase and ribosylnicotinamide (RN) kinase. The DNA-binding domain binds to the nadB operator sequence in an NAD- and ATP-dependent manner. As NAD levels increase within the cell, the affinity of NadR for the nadB operator regions of nadA, nadB, and pncB increases, repressing the transcription of these genes. The RN kinase activity catalyzes the phosphorylation of RN to form nicotinamide ribonucleotide. The NMN adenylyltransferase activity [...] | 0.557 |
yaeP | rof | b4406 | b0189 | UPF0253 family protein; Belongs to the UPF0253 family. | Modulator of Rho-dependent transcription termination; Suppresses temperature-sensitive mutations in essential genes by modulating rho-dependent transcription termination. | 0.931 |
yaeP | thiS | b4406 | b4407 | UPF0253 family protein; Belongs to the UPF0253 family. | Immediate sulfur donor in thiazole formation; Is the sulfur donor in the synthesis of the thiazole phosphate moiety of thiamine phosphate. | 0.811 |
yaeP | yaeQ | b4406 | b0190 | UPF0253 family protein; Belongs to the UPF0253 family. | PDDEXK superfamily protein. | 0.515 |