STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rzoDDLP12 prophage; Component of the spanin complex that disrupts the outer membrane and causes cell lysis during virus exit. The spanin complex conducts the final step in cell lysis by disrupting the outer membrane after holin and endolysin action have permeabilized the inner membrane and degraded the host peptidoglycans (By similarity); Belongs to the lambdalikevirus o-spanin family. (60 aa)    
Predicted Functional Partners:
rrrD
DLP12 prophage; Essential for lysis of bacterial cell wall, by showing cell wall hydrolyzing activity. Exhibits lytic activity against E.coli and S.typhi cell wall substrate; Belongs to the glycosyl hydrolase 24 family.
      
 0.905
rrrQ
Qin prophage; Essential for lysis of bacterial cell wall, by showing cell wall hydrolyzing activity; Belongs to the glycosyl hydrolase 24 family.
      
 0.903
essD
DLP12 prophage; putative phage lysis protein.
      
 0.898
rzpD
DLP12 prophage; Necessary for host cell lysis. It is believed to code for an endopeptidase that cleaves the amino-carboxyl cross-link between the diaminopimelic acid and D-alanine residues in the murein component of the bacterial cell wall (By similarity).
      
 0.816
quuD
DLP12 prophage; Positively regulate expression of some phage genes. Bacterial host RNA polymerase modified by antitermination proteins transcribes through termination sites that otherwise prevent expression of the regulated genes (By similarity); Belongs to the phage antitermination Q type 1 family.
      
 0.810
tfaQ
Qin prophage; Tail fiber assembly protein homolog from lambdoid prophage Qin; Belongs to the tfa family.
      
 0.787
ybfD
H repeat-associated putative transposase YbfD; Pseudogene, DDE domain transposase family;putative factor; Not classified; putative receptor protein; Belongs to the transposase 11 family.
      
 0.782
tfaR
Rac prophage; Tail fiber assembly protein homolog from lambdoid prophage Rac; Belongs to the tfa family.
      
 0.739
pinQ
Qin prophage; putative site-specific recombinase; Belongs to the site-specific recombinase resolvase family.
      
 0.645
ldrC
Small toxic polypeptide.
      
 0.644
Your Current Organism:
Escherichia coli K12
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.