searching ... STRING: functional protein association networks

Ptpn6 - Tyrosine-protein phosphatase non-receptor type 6; Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. [a.k.a. Q921G3, R-MMU-1280218, M90389]

Hck - Tyrosine-protein kinase HCK; Non-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and migration. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as FCGR1A and FCGR2A, but also CSF3R, PLAUR, the receptors for IFNG, IL2, IL6 and IL8, and integrins, such as ITGB1 and ITGB2. During the phagocytic p [...] [a.k.a. ENSMUSP00000003370, AK155975, Hck-204]

Lrfn4 - Leucine-rich repeat and fibronectin type-III domain-containing protein 4; Promotes neurite outgrowth in hippocampal neurons. May play a role in redistributing DLG4 to the cell periphery. [a.k.a. R-MMU-8849932, BC023156, Q460G5]

Ift57 - Intraflagellar transport protein 57 homolog; Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway. Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear. Belongs to the IFT57 family. [a.k.a. 4833420A15Rik, ENSMUST00000127784, ENSMUST00000142682]

Sorl1 - Sortilin-related receptor; Sorting receptor that directs several proteins to their correct location within the cell. Along with AP-1 complex, involved Golgi apparatus - endosome sorting. Sorting receptor for APP, regulating its intracellular trafficking and processing into amyloidogenic-beta peptides. Retains APP in the trans-Golgi network, hence preventing its transit through late endosomes where amyloid beta peptides Abeta40 and Abeta42 are generated. May also sort newly produced amyloid-beta peptides to lysosomes for catabolism. Does not affect APP trafficking from the endoplasmic r [...] [a.k.a. XM_017313238, ENSMUST00000060989, O54711]

Tacstd2 - Tumor-associated calcium signal transducer 2; May function as a growth factor receptor. [a.k.a. ENSMUST00000058178.5, BAC39531.1, EGP-1]

Cldn9 - Claudin-9; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. [a.k.a. CH466606, Claudin 9, ENSMUST00000085989]

Adgrb1 - Adhesion G protein-coupled receptor B1; Phosphatidylserine receptor which enhances the engulfment of apoptotic cells. Also mediates the binding and engulfment of Gram-negative bacteria. Stimulates production of reactive oxygen species by macrophages in response to Gram-negative bacteria, resulting in enhanced microbicidal macrophage activity (By similarity). In the gastric mucosa, required for recognition and engulfment of apoptotic gastric epithelial cells (By similarity). Promotes myoblast fusion. Activates the Rho pathway in a G-protein-dependent manner (By similarity). Inhibits MDM [...] [a.k.a. XP_011243708, XP_011243707.1, XM_011245405.1]

Dazap1 - DAZ-associated protein 1; RNA-binding protein, which may be required during spermatogenesis. [a.k.a. NM_001122605.1, CCDS48626.1, AC140229]

Paqr5 - Membrane progestin receptor gamma; Plasma membrane progesterone (P4) receptor coupled to G proteins. Seems to act through a G(i) mediated pathway. May be involved in oocyte maturation. [a.k.a. XM_006511508, Progestin and adipoQ receptor family member 5, Progestin and adipoQ receptor family member V]

Cldn7 - Claudin-7; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. [a.k.a. AK145504, 53624, B1AR47]

Snai3 - Zinc finger protein SNAI3; Seems to inhibit myoblast differentiation. Transcriptional repressor of E-box-dependent transactivation of downstream myogenic bHLHs genes. Binds preferentially to the canonical E-box sequences 5'- CAGGTG-3' and 5'-CACCTG-3'. [a.k.a. Snai3-201, NP_038942, Smuc]

Kifc5b - Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. [a.k.a. mmu:16580, Kifc5a, Kifc5b-201]

Ccnd2 - G1/S-specific cyclin-D2; Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...] [a.k.a. R-MMU-453279, AK160751, XM_006505460.1]

Col24a1 - Collagen alpha-1(XXIV) chain; Involved in osteoblast differentiation. Belongs to the fibrillar collagen family. [a.k.a. ENSMUST00000029848, COOA1_MOUSE, AC161237]

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