searching ... STRING: functional protein association networks

Poll - DNA polymerase lambda; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. [a.k.a. XP_006527295.1, 56626, mmu:56626]

Mbip - MAP3K12-binding inhibitory protein 1; Inhibits the MAP3K12 activity to induce the activation of the JNK/SAPK pathway. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. [a.k.a. 217588, UPI0000021AC1, NM_145442]

Slc35b1 - Solute carrier family 35 member B1; Probable sugar transporter; Belongs to the nucleotide-sugar transporter family. SLC35B subfamily. [a.k.a. ENSMUST00000146556, ENSMUSP00000021243, E0CXH1]

Ldah - Lipid droplet-associated hydrolase; Serine lipid hydrolase associated with lipid droplets. Highly expressed in macrophage-rich areas in atherosclerotic lesions, suggesting that it could promote cholesterol ester turnover in macrophages; Belongs to the AB hydrolase superfamily. LDAH family. [a.k.a. A0A0F6AIX6, ENSMUSP00000151289, ENSMUST00000219357]

Eprs - Bifunctional glutamate/proline--tRNA ligase; Multifunctional protein which is primarily part of the aminoacyl-tRNA synthetase multienzyme complex, also know as multisynthetase complex, that catalyzes the attachment of the cognate amino acid to the corresponding tRNA in a two-step reaction: the amino acid is first activated by ATP to form a covalent intermediate with AMP and is then transferred to the acceptor end of the cognate tRNA (By similarity). The phosphorylation of EPRS1, induced by interferon-gamma, dissociates the protein from the aminoacyl-tRNA synthetase multienzyme complex [...] [a.k.a. Eprs-207, ENSMUST00000193788, ENSMUSP00000131154]

Ankra2 - Ankyrin repeat family A protein 2; May regulate the interaction between the 3M complex and the histone deacetylases HDAC4 and HDAC5 (By similarity). May also regulate LRP2/megalin. [a.k.a. ENSMUSP00000093184, NM_001271392, UPI000052CAD1]

Efr3a - Protein EFR3 homolog A; Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis. In the complex, EFR3A probably acts as the membrane-anchoring component. Also involved in responsiveness to G- protein-coupled receptors; it is however unclear whether this role is direct or indirect. [a.k.a. ENSMUST00000096411.3, Efr3a-201, A0A1D5RLL3]

Ahcyl1 - S-adenosylhomocysteine hydrolase-like protein 1; Multifaceted cellular regulator which coordinates several essential cellular functions including regulation of epithelial HCO3(-) and fluid secretion, mRNA processing and DNA replication. Regulates ITPR1 sensitivity to inositol 1,4,5-trisphosphate competing for the common binding site and acting as endogenous 'pseudoligand' whose inhibitory activity can be modulated by its phosphorylation status. In the pancreatic and salivary ducts, at resting state, attenuates inositol 1,4,5-trisphosphate-induced calcium release by interacting with ITP [...] [a.k.a. ENSMUST00000137583.1, NM_001357113.1, R-MMU-5578775]

Slc19a1 - Reduced folate transporter; Transporter that mediates the import of reduced folates. Has high affinity for N5-methyltetrahydrofolate, the predominant circulating form of folate. Also able to mediate the import of antifolate drug methotrexate. Mechanistically, acts as an antiporter, which export of intracellular organic anions to facilitate uptake of its substrates (By similarity). 5-amino-4- imidazolecarboxamide riboside (AICAR), when phosphorylated to AICAR monophosphate, can serve as an organic anion for antiporter activity (By similarity). [a.k.a. AAB38483.1, Slc19a1-208, Q62450]

Fdxr - NADPH:adrenodoxin oxidoreductase, mitochondrial; Serves as the first electron transfer protein in all the mitochondrial P450 systems including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C- 27 hydroxylation in the liver. [a.k.a. NM_007997, ENSMUST00000021078.2, 14149]

Bcl2l2 - Bcl-2-like protein 2; Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX. Belongs to the Bcl-2 family. [a.k.a. XM_006518457.3, ENSMUSP00000107101, Gtrgal2]

Rnf7 - RING-box protein 2; Probable component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription (By similarity). CRLs complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins, ARIH1 mediating addition of the first ubiquitin on CRLs targets (By similarity). Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity [...] [a.k.a. R-MMU-1280218, Rbx2, NP_035409]

Ddx10 - Probable ATP-dependent RNA helicase DDX10; Putative ATP-dependent RNA helicase. [a.k.a. Probable ATP-dependent RNA helicase DDX10, ENSMUSG00000053289, 4632415A01Rik]

Esyt2 - Extended synaptotagmin-2; Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport. Plays a role in FGF signaling via its role in the rapid internalization of FGFR1 that has been activated by FGF1 binding; this occurs most likely via the AP- 2 complex (By similarity). [a.k.a. A0A1Y7VNA1, D12Ertd551e, NM_028731]

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