searching ... STRING: functional protein association networks

Tmprss3 - Transmembrane protease serine 3; Probable serine protease that plays a role in hearing. Acts as a permissive factor for cochlear hair cell survival and activation at the onset of hearing and is required for saccular hair cell survival. Activates ENaC (in vitro). [a.k.a. Q8VDE0, XR_001782038, S01.079]

Sfrp4 - Secreted frizzled-related sequence protein 4; Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP4 plays a role in bone morphogenesis. May also act as a regulator of adult uterine morphology and function. May also increase apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling (By similarity). Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake (By similarity). [a.k.a. ENSMUSG00000021319, NP_057896.1, uc007ppg.2]

Crebl2 - cAMP-responsive element-binding protein-like 2; Probable regulator of CREB1 transcriptional activity which is involved in adipose cells differentiation. May also play a regulatory role in the cell cycle. [a.k.a. Crebl2-201, XM_011241325.2, Crebl2-204]

Spdef - SAM pointed domain-containing Ets transcription factor; May function as an androgen-independent transactivator of the prostate-specific antigen (PSA) promoter. Binds to 5'-GGAT-3' DNA sequences. May play a role in the regulation of the prostate gland and/or prostate cancer development. Acts as a transcriptional activator for SERPINB5 promoter (By similarity); Belongs to the ETS family. [a.k.a. XP_006524442, NM_013891, XM_017317499.1]

Sst - Somatostatin-14; [Somatostatin-14]: Inhibits the secretion of pituitary hormones, including that of growth hormone/somatotropin (GH1), PRL, ACTH, luteinizing hormone (LH) and TSH. Also impairs ghrelin- and GnRH- stimulated secretion of GH1 and LH; the inhibition of ghrelin- stimulated secretion of GH1 can be further increased by neuronostatin. [a.k.a. ENSMUST00000004480, Somatostatin-14, P60041]

Cldn9 - Claudin-9; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. [a.k.a. CH466606, Claudin 9, ENSMUST00000085989]

Tnks - Poly [ADP-ribose] polymerase tankyrase-1; Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly- ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Medi [...] [a.k.a. ADP-ribosyltransferase diphtheria toxin-like 5, D130072O21Rik, Tnks-206]

Piezo2 - Piezo-type mechanosensitive ion channel component 2; Component of a mechanosensitive channel required for rapidly adapting mechanically activated (MA) currents. Required for Merkel-cell mechanotransduction. Plays a major role in light-touch mechanosensation ; Belongs to the PIEZO (TC 1.A.75) family. [a.k.a. XM_006526172.3, ENSMUST00000137141.2, ENSMUSP00000138758]

Edaradd - Ectodysplasin-A receptor-associated adapter protein; Adapter protein that interacts with EDAR DEATH domain and couples the receptor to EDA signaling pathway during morphogenesis of ectodermal organs. Mediates the activation of NF-kappa-B (By similarity). [a.k.a. ENSMUST00000179308, 5830469M23Rik, CT954220]

Pcsk1 - Neuroendocrine convertase 1; Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin, insulin and AGRP. [a.k.a. CAA40368.1, CH466563, ENSMUSP00000152702]

Mrvi1 - Protein MRVI1; Plays a role as NO/PRKG1-dependent regulator of IP3-induced calcium release; its phosphorylation by PRKG1 inhibits bradykinin and IP3-induced calcium release from intracellular stores. Recruits PRKG1 to the endoplasmic reticulum and may mediate the assembly of PRKG1 and ITPR1 in a macrocomplex. Involved in PRKG1 signaling cascade leading to inhibition of platelet activation and aggregation. Mediates also NO- dependent inhibition of calcium signaling in gastrointestinal smooth muscle contributing to NO-dependent relaxation. [a.k.a. Ris1, 17540, ENSMUST00000127935]

Clcnkb - Chloride channel protein ClC-Kb; Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. May be important in urinary concentrating mechanisms. May be the basolateral chloride channel mediating net chloride absorption in CTAL cells; Belongs to the chloride channel (TC 2.A.49) family. CLCNKB subfamily. [a.k.a. ENSMUST00000145725, XP_011248609, ENSMUST00000006378]

Cntnap1 - Contactin-associated protein 1; Required, with CNTNAP2, for radial and longitudinal organization of myelinated axons. Plays a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Demarcates the paranodal region of the axo-glial junction. In association with contactin involved in the signaling between axons and myelinating glial cells. [a.k.a. ENSMUST00000138942, XM_006533728.3, Neurexin IV]

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