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The following proteins in
Homo sapiens
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102 query items
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1) '9606.ENSP00000300692':
CD3D - T-cell surface glycoprotein CD3 delta chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of [...]
[a.k.a. P04234, 915, BC070321]
2) '9606.ENSP00000360317':
CYP2C8 - Cytochrome P450 2C8; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Primarily catalyzes the epoxidation of double bonds of polyunsaturated fatty acids (PUFA) with a preference for the last double bond. Catalyzes the hydroxylation of carbon-hydrogen bonds. Metabol [...]
[a.k.a. R-HSA-211999, ENSP00000442343, S-mephenytoin 4-hydroxylase]
3) '9606.ENSP00000369654':
- - Sorry, STRING found no proteins by this name in Homo sapiens - -
4) '9606.ENSP00000318916':
MARCO - Macrophage receptor MARCO; Pattern recognition receptor (PRR) which binds Gram-positive and Gram-negative bacteria. Also plays a role in binding of unopsonized particles by alveolar macrophages (By similarity). Binds to the secretoglobin SCGB3A2.
[a.k.a. AF128183, ENST00000263709, NP_006761]
5) '9606.ENSP00000384053':
CSF2RB - Cytokine receptor common subunit beta; High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor.
[a.k.a. R-HSA-912526, M59941, beta-GM-CSF receptor]
6) '9606.ENSP00000317257':
CPNE1 - Copine-1; Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Involved in the TNF-alpha receptor signaling pathway in a calcium- dependent manner. Exhibits calcium-dependent phospholipid binding properties. Plays a role in neuronal progenitor cell differentiation; induces neurite outgrowth via a AKT-dependent signaling cascade and calcium- independent manner. May recruit target proteins to the cell membrane in a calcium-dependent manner. May function in membrane trafficking. Involved in TNF-alpha-induced NF-kappa-B transcription [...]
[a.k.a. ENST00000414711, copine 1, ENST00000439806]
7) '9606.ENSP00000299964':
- - Sorry, STRING found no proteins by this name in Homo sapiens - -
8) '9606.ENSP00000349252':
ITGAL - Integrin alpha-L; Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is a receptor for F11R. Integin ITGAL/ITGB2 is a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL. Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Contributes to natural killer cell cytotoxicity. Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutroph [...]
[a.k.a. M87662, R-HSA-202733, 6CKB]
9) '9606.ENSP00000231009':
GZMK - Granzyme K; Belongs to the peptidase S1 family. Granzyme subfamily.
[a.k.a. P49863, ENSP00000231009, ENSG00000113088]
10) '9606.ENSP00000323929':
A2M - Alpha-2-macroglobulin; Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region, a thioester bond is hydrolyzed and mediates the c [...]
[a.k.a. NM_001347424.1, URS00008BF993, R-HSA-162582]
11) '9606.ENSP00000352833':
PTPN22 - Tyrosine-protein phosphatase non-receptor type 22; Acts as negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules. Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue. Dephosphorylates ZAP70 at its activating 'Tyr-493' residue. Dephosphorylates the immune system activator SKAP2. Positively regulates toll-like receptor (TLR)-induced type 1 interferon production. Promotes host [...]
[a.k.a. PEST-domain phosphatase, NM_015967, XP_011539524]
12) '9606.ENSP00000326407':
CLEC1A - C-type lectin domain family 1 member A.
[a.k.a. ENST00000420265.2, CCDS8612.1, CLEC1A-201]
13) '9606.ENSP00000405533':
- - Sorry, STRING found no proteins by this name in Homo sapiens - -
14) '9606.ENSP00000377978':
- - Sorry, STRING found no proteins by this name in Homo sapiens - -
15) '9606.ENSP00000333994':
- - Sorry, STRING found no proteins by this name in Homo sapiens - -
16) '9606.ENSP00000323280':
CD6 - T-cell differentiation antigen CD6; Cell adhesion molecule that mediates cell-cell contacts and regulates T-cell responses via its interaction with ALCAM/CD166. Contributes to signaling cascades triggered by activation of the TCR/CD3 complex. Functions as costimulatory molecule; promotes T-cell activation and proliferation. Contributes to the formation and maturation of the immunological synapse. Functions as calcium- dependent pattern receptor that binds and aggregates both Gram-positive and Gram-negative bacteria. Binds both lipopolysaccharide (LPS) from Gram-negative bacteria and li [...]
[a.k.a. XM_011545362.1, URS00008B201A, ENST00000244880]
17) '9606.ENSP00000311873':
- - Sorry, STRING found no proteins by this name in Homo sapiens - -
18) '9606.ENSP00000265104':
DNAH5 - Dynein heavy chain 5, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required for structural and functional integrity of the cilia of ependymal cells lining the brain ventricles.
[a.k.a. ENST00000265104, NX_Q8TE73, PCD]
19) '9606.ENSP00000331736':
SELE - E-selectin; Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with SELPLG/PSGL1. May have a role in capillary morphogenesis; Belongs to the selectin/LECAM family.
[a.k.a. M30640, 4C16, ENSP00000356750]
20) '9606.ENSP00000299721':
CPLX4 - Complexin-4; Complexin that regulates SNARE protein complex-mediated synaptic vesicle fusion (By similarity). Required for the maintenance of synaptic ultrastructure in the adult retina (By similarity). Positively regulates synaptic transmission through synaptic vesicle availability and exocytosis of neurotransmitters at photoreceptor ribbon synapses in the retina (By similarity). Suppresses tonic photoreceptor activity and baseline 'noise' by suppression of Ca(2+) vesicle tonic release and the facilitation of evoked synchronous and asynchronous Ca(2+) vesicle release (By similarity). [...]
[a.k.a. OTTHUMG00000132756, BC106887, AC067859]
102 query items
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