glpD protein (Mycoplasma pneumoniae M129) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

glpD

Glycerol-3-phospate dehydrogenase; MPN051(new), 103(Himmelreich et al., 1996). (384 aa)

Predicted Functional Partners:

glpK

0.953

ygiH

0.904

ldh

0.871

glpF

0.845

plsB

0.811

ptsG

0.552

ptsH

0.528

D09_orf657

0.522

gap

0.468

nox

0.456

Your Current Organism:

Mycoplasma pneumoniae M129

NCBI taxonomy Id: 272634
Other names: M. pneumoniae M129, Mycoplasma pneumoniae ATCC 29342, Mycoplasma pneumoniae str. M129, Mycoplasma pneumoniae strain M129

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
D09_orf657	glpD	MPN_052	MPN_051	Putative lipoprotein; MPN052(new), 102(Himmelreich et al., 1996).	Glycerol-3-phospate dehydrogenase; MPN051(new), 103(Himmelreich et al., 1996).	0.522
D09_orf657	glpK	MPN_052	MPN_050	Putative lipoprotein; MPN052(new), 102(Himmelreich et al., 1996).	Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family.	0.509
D09_orf657	ptsH	MPN_052	MPN_053	Putative lipoprotein; MPN052(new), 102(Himmelreich et al., 1996).	Phosphocarrier protein HPr; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the PTS EIIA domain.	0.779
gap	glpD	MPN_430	MPN_051	Glycerladehyde-3-phosphate dehydrogenase; Catalyzes the oxidative phosphorylation of glyceraldehyde 3- phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG; Belongs to the glyceraldehyde-3-phosphate dehydrogenase [...]	Glycerol-3-phospate dehydrogenase; MPN051(new), 103(Himmelreich et al., 1996).	0.468
gap	glpK	MPN_430	MPN_050	Glycerladehyde-3-phosphate dehydrogenase; Catalyzes the oxidative phosphorylation of glyceraldehyde 3- phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG; Belongs to the glyceraldehyde-3-phosphate dehydrogenase [...]	Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family.	0.445
gap	ldh	MPN_430	MPN_674	Glycerladehyde-3-phosphate dehydrogenase; Catalyzes the oxidative phosphorylation of glyceraldehyde 3- phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG; Belongs to the glyceraldehyde-3-phosphate dehydrogenase [...]	L-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family.	0.932
gap	ptsG	MPN_430	MPN_207	Glycerladehyde-3-phosphate dehydrogenase; Catalyzes the oxidative phosphorylation of glyceraldehyde 3- phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG; Belongs to the glyceraldehyde-3-phosphate dehydrogenase [...]	PTS system, glucose-specific IIABC component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in glucose transport.	0.692
glpD	D09_orf657	MPN_051	MPN_052	Glycerol-3-phospate dehydrogenase; MPN051(new), 103(Himmelreich et al., 1996).	Putative lipoprotein; MPN052(new), 102(Himmelreich et al., 1996).	0.522
glpD	gap	MPN_051	MPN_430	Glycerol-3-phospate dehydrogenase; MPN051(new), 103(Himmelreich et al., 1996).	Glycerladehyde-3-phosphate dehydrogenase; Catalyzes the oxidative phosphorylation of glyceraldehyde 3- phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG; Belongs to the glyceraldehyde-3-phosphate dehydrogenase [...]	0.468
glpD	glpF	MPN_051	MPN_043	Glycerol-3-phospate dehydrogenase; MPN051(new), 103(Himmelreich et al., 1996).	Glycerol uptake facilitator; Glycerol enters the cell via the glycerol diffusion facilitator protein. This membrane protein facilitates the movement of glycerol across the cytoplasmic membrane (By similarity).	0.845
glpD	glpK	MPN_051	MPN_050	Glycerol-3-phospate dehydrogenase; MPN051(new), 103(Himmelreich et al., 1996).	Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family.	0.953
glpD	ldh	MPN_051	MPN_674	Glycerol-3-phospate dehydrogenase; MPN051(new), 103(Himmelreich et al., 1996).	L-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family.	0.871
glpD	nox	MPN_051	MPN_394	Glycerol-3-phospate dehydrogenase; MPN051(new), 103(Himmelreich et al., 1996).	NADH oxidase; Catalyzes the four-electron reduction of molecular oxygen to water.	0.456
glpD	plsB	MPN_051	MPN_299	Glycerol-3-phospate dehydrogenase; MPN051(new), 103(Himmelreich et al., 1996).	1-acyl-sn-glycerol-3-phosphate acyltransferase; Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating acyl moiety at the 2 position; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.	0.811
glpD	ptsG	MPN_051	MPN_207	Glycerol-3-phospate dehydrogenase; MPN051(new), 103(Himmelreich et al., 1996).	PTS system, glucose-specific IIABC component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in glucose transport.	0.552
glpD	ptsH	MPN_051	MPN_053	Glycerol-3-phospate dehydrogenase; MPN051(new), 103(Himmelreich et al., 1996).	Phosphocarrier protein HPr; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the PTS EIIA domain.	0.528
glpD	ygiH	MPN_051	MPN_350	Glycerol-3-phospate dehydrogenase; MPN051(new), 103(Himmelreich et al., 1996).	Conserved hypothetical protein; Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.	0.904
glpF	glpD	MPN_043	MPN_051	Glycerol uptake facilitator; Glycerol enters the cell via the glycerol diffusion facilitator protein. This membrane protein facilitates the movement of glycerol across the cytoplasmic membrane (By similarity).	Glycerol-3-phospate dehydrogenase; MPN051(new), 103(Himmelreich et al., 1996).	0.845
glpF	glpK	MPN_043	MPN_050	Glycerol uptake facilitator; Glycerol enters the cell via the glycerol diffusion facilitator protein. This membrane protein facilitates the movement of glycerol across the cytoplasmic membrane (By similarity).	Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family.	0.987
glpF	plsB	MPN_043	MPN_299	Glycerol uptake facilitator; Glycerol enters the cell via the glycerol diffusion facilitator protein. This membrane protein facilitates the movement of glycerol across the cytoplasmic membrane (By similarity).	1-acyl-sn-glycerol-3-phosphate acyltransferase; Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating acyl moiety at the 2 position; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.	0.445