node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
apt | deoA | MPN_395 | MPN_064 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Thymidine phosphorylase; The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis. | 0.760 |
apt | deoD | MPN_395 | MPN_062 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Purine-nucleoside phosphorylase; MPN062(new), 092(Himmelreich et al., 1996). | 0.944 |
apt | tdk | MPN_395 | MPN_044 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Thymidine kinase; MPN044(new), 110(Himmelreich et al., 1996). | 0.485 |
apt | thyA | MPN_395 | MPN_320 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.508 |
apt | upp | MPN_395 | MPN_033 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.686 |
apt | yaaF | MPN_395 | MPN_386 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Deoxyguanosine kinase/deoxyadenosine kinase; MPN386(new), 452(Himmelreich et al., 1996). | 0.725 |
cdd | cpsG | MPN_065 | MPN_066 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. | CpsG; MPN066(new), 088(Himmelreich et al., 1996); similar to phosphomannomutase and phosphoglucomutase; Belongs to the phosphohexose mutase family. | 0.888 |
cdd | deoA | MPN_065 | MPN_064 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. | Thymidine phosphorylase; The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis. | 0.990 |
cdd | deoC | MPN_065 | MPN_063 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. | Deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. | 0.958 |
cdd | deoD | MPN_065 | MPN_062 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. | Purine-nucleoside phosphorylase; MPN062(new), 092(Himmelreich et al., 1996). | 0.989 |
cdd | tdk | MPN_065 | MPN_044 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. | Thymidine kinase; MPN044(new), 110(Himmelreich et al., 1996). | 0.925 |
cdd | thyA | MPN_065 | MPN_320 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.436 |
cdd | upp | MPN_065 | MPN_033 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.473 |
cdd | yaaF | MPN_065 | MPN_386 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. | Deoxyguanosine kinase/deoxyadenosine kinase; MPN386(new), 452(Himmelreich et al., 1996). | 0.554 |
cpsG | cdd | MPN_066 | MPN_065 | CpsG; MPN066(new), 088(Himmelreich et al., 1996); similar to phosphomannomutase and phosphoglucomutase; Belongs to the phosphohexose mutase family. | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. | 0.888 |
cpsG | deoA | MPN_066 | MPN_064 | CpsG; MPN066(new), 088(Himmelreich et al., 1996); similar to phosphomannomutase and phosphoglucomutase; Belongs to the phosphohexose mutase family. | Thymidine phosphorylase; The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis. | 0.836 |
cpsG | deoC | MPN_066 | MPN_063 | CpsG; MPN066(new), 088(Himmelreich et al., 1996); similar to phosphomannomutase and phosphoglucomutase; Belongs to the phosphohexose mutase family. | Deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. | 0.951 |
cpsG | deoD | MPN_066 | MPN_062 | CpsG; MPN066(new), 088(Himmelreich et al., 1996); similar to phosphomannomutase and phosphoglucomutase; Belongs to the phosphohexose mutase family. | Purine-nucleoside phosphorylase; MPN062(new), 092(Himmelreich et al., 1996). | 0.832 |
deoA | apt | MPN_064 | MPN_395 | Thymidine phosphorylase; The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.760 |
deoA | cdd | MPN_064 | MPN_065 | Thymidine phosphorylase; The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis. | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. | 0.990 |