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Orf7 Orf7 dnaN dnaN holB holB dnaE-3 dnaE-3 dnaX dnaX polC polC Orf8 Orf8 come3 come3 mucB mucB hmw3 hmw3 Orf6 Orf6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
Orf7Conserved hypothetical protein; MPN450(new), 390(Himmelreich et al., 1996). (314 aa)    
Predicted Functional Partners:
dnaN
DNA polymerase III beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
   
 0.999
holB
DNA-polymerase-like protein; MPN007(new), 147(Himmelreich et al., 1996).
    
 0.999
dnaE-3
DNA polymerase III alpha subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase (By similarity); Belongs to the DNA polymerase type-C family. DnaE subfamily.
  
 0.999
dnaX
DnaX; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.
  
 0.999
polC
DNA polymerase III (dnaE) alpha chain; Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity; Belongs to the DNA polymerase type-C family. PolC subfamily.
    
 0.928
Orf8
Conserved hypothetical protein; MPN449(new), 391(Himmelreich et al., 1996).
     
 0.850
come3
Competence locus operon protein 3-like protein; MPN451(new), 389(Himmelreich et al., 1996); similar to Swiss-Prot Accession Number P39695.
     
 0.808
mucB
UV protection protein MucB; MPN537(new), 305(Himmelreich et al., 1996); Belongs to the DNA polymerase type-Y family.
     
 0.762
hmw3
Cytadherence accessory protein HMW3; Component of the cytoskeleton-like structure which stabilizes the shape of the wall-less mycoplasma. This cytoskeleton-like network of accessory proteins containing HMW proteins 1 to 5 allows the proper anchoring of cytadhesin proteins in the mycoplasmal membrane at the attachment organelle. Essential for successful surface parasitism.
       0.650
Orf6
Cytadherence protein; MPN142(new), 013(Himmelreich et al., 1996).
      
 0.633
Your Current Organism:
Mycoplasma pneumoniae M129
NCBI taxonomy Id: 272634
Other names: M. pneumoniae M129, Mycoplasma pneumoniae ATCC 29342, Mycoplasma pneumoniae str. M129, Mycoplasma pneumoniae strain M129
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