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There are several matches for 'APOE'.
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organism
protein
1)
Homo sapiens
APOE
- Apolipoprotein E;
APOE
is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids.
APOE
is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such,
APOE
associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]
2)
Homo sapiens
APOB - Apolipoprotein B-100; Apolipoprotein B is a major protein constituent of chylomicrons (
apo
B-48), LDL (
apo
B-100) and VLDL (
apo
B-100).
Apo
B- 100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor.
[a.k.a. R-HSA-388396, Apo B-48, R-HSA-196854]
3)
Homo sapiens
SLC22A17 - Solute carrier family 22 member 17; Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo- 24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (
apo
-24p3), followed by internalization of
apo
-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resu [...]
[a.k.a. ENST00000335680, NR_110290, ENST00000397263]
4)
Homo sapiens
APOF - Apolipoprotein F; Minor apolipoprotein that associates with LDL. Inhibits cholesteryl ester transfer protein (CETP) activity and appears to be an important regulator of cholesterol transport. Also associates to a lesser degree with VLDL,
Apo
-AI and
Apo
-AII.
[a.k.a. CCDS44923, AAH26257.1, Apolipoprotein F]
5)
Homo sapiens
YAE1 - Protein YAE1 homolog; The complex LTO1:YAE1 functions as a target specific adapter that probably recruits
apo
-ABCE1 to the cytosolic iron-sulfur protein assembly (CIA) complex machinery. May be required for biogenesis of the large ribosomal subunit and initiation of translation.
[a.k.a. AAQ96864.1, CAG33479.1, NM_020192.4]
6)
Homo sapiens
LCAT - Phosphatidylcholine-sterol acyltransferase; Central enzyme in the extracellular metabolism of plasma lipoproteins. Synthesized mainly in the liver and secreted into plasma where it converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high and low density lipoproteins (HDLs and LDLs). The cholesterol ester is then transported back to the liver. Has a preference for plasma 16:0-18:2 or 18:O-18:2 phosphatidylcholines. Also produced in the brain by primary astrocytes, and esterifies free cholesterol on nascent
APOE
-c [...]
[a.k.a. Lecithin-cholesterol acyltransferase, I3L0J6, NM_000229.1]
7)
Homo sapiens
LTO1 - Protein LTO1 homolog; The complex LTO1:YAE1 functions as a target specific adapter that probably recruits
apo
-ABCE1 to the cytosolic iron-sulfur protein assembly (CIA) complex machinery. May be required for biogenesis of the large ribosomal subunit and initiation of translation. May play a role in the regulation of proline metabolism and ROS production.
[a.k.a. F5GZY6, JX460858, LTO1-215]
8)
Homo sapiens
LRP8 - Low-density lipoprotein receptor-related protein 8; Cell surface receptor for Reelin (RELN) and apolipoprotein E (
apoE
)-containing ligands. LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the forebrain during embryonic brai [...]
[a.k.a. XM_006710882.4, ENST00000335236, R-HSA-388396]
9)
Homo sapiens
LPA - Apolipoprotein(a);
Apo
(a) is the main constituent of lipoprotein(a) (Lp(a)). It has serine proteinase activity and is able of autoproteolysis. Inhibits tissue-type plasminogen activator 1. Lp(a) may be a ligand for megalin/Gp 330; Belongs to the peptidase S1 family. Plasminogen subfamily.
[a.k.a. Q5VTD7, ENSG00000198670, lipoprotein, Lp(a)]
10)
Homo sapiens
BCO2 - Beta,beta-carotene 9',10'-oxygenase; Asymmetrically cleaves beta-carotene at the 9',10' double bond resulting in the formation of beta-
apo
-10'-carotenal and beta- ionone. Besides beta-carotene, lycopene is also oxidatively cleaved. The apocarotenals formed by this enzyme may be the precursors for the biosynthesis of retinoic acid or exert unknown physiological effects. Belongs to the carotenoid oxygenase family.
[a.k.a. R-HSA-388396, R-HSA-196854, NP_114144.5]
11)
Homo sapiens
TMCC2 - Transmembrane and coiled-coil domains protein 2; May be involved in the regulation of the proteolytic processing of the amyloid precursor protein (APP) possibly also implicating
APOE
.
[a.k.a. XM_005245685, BAG37022.1, ENST00000648708.1]
12)
Homo sapiens
LRP10 - Low-density lipoprotein receptor-related protein 10; Probable receptor, which is involved in the internalization of lipophilic molecules and/or signal transduction. May be involved in the uptake of lipoprotein
APOE
in liver (By similarity); Belongs to the LDLR family.
[a.k.a. R-HSA-388396, Q7Z4F1, R-HSA-196854]
13)
Homo sapiens
APOA5 - Apolipoprotein A-V; Minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. May also be associated with chylomicrons. Important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of
apo
-CII lipoprotein lipase (LPL) TG hydrolysis and an inhibitor of the hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate) (By similarity). Activates poorly lecithin:cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages. Binds heparin.
[a.k.a. ENSP00000399701, APOA5_HUMAN, AAS68229.1]
14)
Homo sapiens
MAP3K12 - Mitogen-activated protein kinase kinase kinase 12; Part of a non-canonical MAPK signaling pathway. Activated by
APOE
, enhances the AP-1-mediated transcription of APP, via a MAP kinase signal transduction pathway composed of MAP2K7 and MAPK1/ERK2 and MAPK3/ERK1. May be an activator of the JNK/SAPK pathway.
[a.k.a. ZPK, URS0000CE8170, ENST00000548690.1]
15)
Homo sapiens
APOBR - Apolipoprotein B receptor; Macrophage receptor that binds to the apolipoprotein B48 (APOB) of dietary triglyceride (TG)-rich lipoproteins (TRL) or to a like domain of APOB in hypertriglyceridemic very low density lipoprotein (HTG-VLDL). Binds and internalizes TRL when out of the context of the macrophage. May provide essential lipids to reticuloendothelial cells. Could also be involved in foam cell formation with elevated TRL and remnant lipoprotein (RLP). Mediates the rapid high-affinity uptake of chylomicrons (CM), HTG-VLDL, and trypsinized (tryp) VLDL devoid of
APOE
in vitro in macr [...]
[a.k.a. ENSG00000184730, NP_061160.3, R-HSA-8964046]