node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cbx1 | Cenpv | ENSMUSP00000091475 | ENSMUSP00000018653 | Chromobox protein homolog 1; Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane. | Centromere protein V; Required for distribution of pericentromeric heterochromatin in interphase nuclei and for centromere formation and organization, chromosome alignment and cytokinesis; Belongs to the Gfa family. | 0.494 |
Ccdc181 | Cenpv | ENSMUSP00000027867 | ENSMUSP00000018653 | Coiled-coil domain-containing protein 181; Microtubule-binding protein that localizes to the microtubular manchette of elongating spermatids. | Centromere protein V; Required for distribution of pericentromeric heterochromatin in interphase nuclei and for centromere formation and organization, chromosome alignment and cytokinesis; Belongs to the Gfa family. | 0.561 |
Ccdc181 | Ppp1r32 | ENSMUSP00000027867 | ENSMUSP00000158578 | Coiled-coil domain-containing protein 181; Microtubule-binding protein that localizes to the microtubular manchette of elongating spermatids. | Protein phosphatase 1 regulatory subunit 32. | 0.722 |
Cdca3 | Cenpv | ENSMUSP00000024270 | ENSMUSP00000018653 | Cell division cycle-associated protein 3; F-box-like protein which is required for entry into mitosis. Acts by participating in E3 ligase complexes that mediate the ubiquitination and degradation of WEE1 kinase at G2/M phase (By similarity). | Centromere protein V; Required for distribution of pericentromeric heterochromatin in interphase nuclei and for centromere formation and organization, chromosome alignment and cytokinesis; Belongs to the Gfa family. | 0.571 |
Cenpq | Cenpv | ENSMUSP00000084353 | ENSMUSP00000018653 | Centromere protein Q; Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Plays an important role in chromosome congression and in the recruitment of CENP-O complex (which comprises CENPO, CENPP, CENPQ and CENPU), CENPE and PLK1 to the kinetochores. | Centromere protein V; Required for distribution of pericentromeric heterochromatin in interphase nuclei and for centromere formation and organization, chromosome alignment and cytokinesis; Belongs to the Gfa family. | 0.585 |
Cenpq | Mei4 | ENSMUSP00000084353 | ENSMUSP00000061341 | Centromere protein Q; Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Plays an important role in chromosome congression and in the recruitment of CENP-O complex (which comprises CENPO, CENPP, CENPQ and CENPU), CENPE and PLK1 to the kinetochores. | Meiosis-specific protein MEI4; Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with IHO1/CCDC36 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis ; Belongs to the MEI4L family. | 0.526 |
Cenpv | Cbx1 | ENSMUSP00000018653 | ENSMUSP00000091475 | Centromere protein V; Required for distribution of pericentromeric heterochromatin in interphase nuclei and for centromere formation and organization, chromosome alignment and cytokinesis; Belongs to the Gfa family. | Chromobox protein homolog 1; Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane. | 0.494 |
Cenpv | Ccdc181 | ENSMUSP00000018653 | ENSMUSP00000027867 | Centromere protein V; Required for distribution of pericentromeric heterochromatin in interphase nuclei and for centromere formation and organization, chromosome alignment and cytokinesis; Belongs to the Gfa family. | Coiled-coil domain-containing protein 181; Microtubule-binding protein that localizes to the microtubular manchette of elongating spermatids. | 0.561 |
Cenpv | Cdca3 | ENSMUSP00000018653 | ENSMUSP00000024270 | Centromere protein V; Required for distribution of pericentromeric heterochromatin in interphase nuclei and for centromere formation and organization, chromosome alignment and cytokinesis; Belongs to the Gfa family. | Cell division cycle-associated protein 3; F-box-like protein which is required for entry into mitosis. Acts by participating in E3 ligase complexes that mediate the ubiquitination and degradation of WEE1 kinase at G2/M phase (By similarity). | 0.571 |
Cenpv | Cenpq | ENSMUSP00000018653 | ENSMUSP00000084353 | Centromere protein V; Required for distribution of pericentromeric heterochromatin in interphase nuclei and for centromere formation and organization, chromosome alignment and cytokinesis; Belongs to the Gfa family. | Centromere protein Q; Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Plays an important role in chromosome congression and in the recruitment of CENP-O complex (which comprises CENPO, CENPP, CENPQ and CENPU), CENPE and PLK1 to the kinetochores. | 0.585 |
Cenpv | Def8 | ENSMUSP00000018653 | ENSMUSP00000104460 | Centromere protein V; Required for distribution of pericentromeric heterochromatin in interphase nuclei and for centromere formation and organization, chromosome alignment and cytokinesis; Belongs to the Gfa family. | Differentially expressed in FDCP 8; Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts. Involved in bone resorption. | 0.465 |
Cenpv | Inafm1 | ENSMUSP00000018653 | ENSMUSP00000127027 | Centromere protein V; Required for distribution of pericentromeric heterochromatin in interphase nuclei and for centromere formation and organization, chromosome alignment and cytokinesis; Belongs to the Gfa family. | InaF motif-containing 1. | 0.489 |
Cenpv | Leng8 | ENSMUSP00000018653 | ENSMUSP00000046465 | Centromere protein V; Required for distribution of pericentromeric heterochromatin in interphase nuclei and for centromere formation and organization, chromosome alignment and cytokinesis; Belongs to the Gfa family. | Leukocyte receptor cluster member 8 homolog. | 0.454 |
Cenpv | Mei4 | ENSMUSP00000018653 | ENSMUSP00000061341 | Centromere protein V; Required for distribution of pericentromeric heterochromatin in interphase nuclei and for centromere formation and organization, chromosome alignment and cytokinesis; Belongs to the Gfa family. | Meiosis-specific protein MEI4; Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with IHO1/CCDC36 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis ; Belongs to the MEI4L family. | 0.499 |
Cenpv | Ppp1r32 | ENSMUSP00000018653 | ENSMUSP00000158578 | Centromere protein V; Required for distribution of pericentromeric heterochromatin in interphase nuclei and for centromere formation and organization, chromosome alignment and cytokinesis; Belongs to the Gfa family. | Protein phosphatase 1 regulatory subunit 32. | 0.563 |
Cenpv | Tspan2 | ENSMUSP00000018653 | ENSMUSP00000029451 | Centromere protein V; Required for distribution of pericentromeric heterochromatin in interphase nuclei and for centromere formation and organization, chromosome alignment and cytokinesis; Belongs to the Gfa family. | Tetraspanin-2; May play a role in signalling in oligodendrocytes in the early stages of their terminal differentiation into myelin-forming glia and may also function in stabilizing the mature sheath; Belongs to the tetraspanin (TM4SF) family. | 0.500 |
Def8 | Cenpv | ENSMUSP00000104460 | ENSMUSP00000018653 | Differentially expressed in FDCP 8; Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts. Involved in bone resorption. | Centromere protein V; Required for distribution of pericentromeric heterochromatin in interphase nuclei and for centromere formation and organization, chromosome alignment and cytokinesis; Belongs to the Gfa family. | 0.465 |
Def8 | Leng8 | ENSMUSP00000104460 | ENSMUSP00000046465 | Differentially expressed in FDCP 8; Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts. Involved in bone resorption. | Leukocyte receptor cluster member 8 homolog. | 0.481 |
Inafm1 | Cenpv | ENSMUSP00000127027 | ENSMUSP00000018653 | InaF motif-containing 1. | Centromere protein V; Required for distribution of pericentromeric heterochromatin in interphase nuclei and for centromere formation and organization, chromosome alignment and cytokinesis; Belongs to the Gfa family. | 0.489 |
Leng8 | Cenpv | ENSMUSP00000046465 | ENSMUSP00000018653 | Leukocyte receptor cluster member 8 homolog. | Centromere protein V; Required for distribution of pericentromeric heterochromatin in interphase nuclei and for centromere formation and organization, chromosome alignment and cytokinesis; Belongs to the Gfa family. | 0.454 |