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Ebpl Ebpl Atp6v1f Atp6v1f Atp6v0b Atp6v0b Atp6v0d1 Atp6v0d1 Atp6v0d2 Atp6v0d2 Tm6sf1 Tm6sf1 Dhcr24 Dhcr24 Tsr3 Tsr3 Sc5d Sc5d Plpp5 Plpp5 Tmem158 Tmem158
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
EbplEmopamil-binding protein-like; Does not possess sterol isomerase activity and does not bind sigma ligands. (206 aa)    
Predicted Functional Partners:
Atp6v1f
V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
    
 
 0.651
Atp6v0b
V-type proton ATPase 21 kDa proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
    
 
 0.616
Atp6v0d1
V-type proton ATPase subunit d 1; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis. May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium (By similarity). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the acti [...]
    
 
 0.596
Atp6v0d2
V-type proton ATPase subunit d 2; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system (By similarity). May play a role in coupling of proton transport and ATP hydrolysis. Regulator of osteoclast fusion and bone formation. Belongs to the V-ATPase V0D/AC39 subunit family.
    
 
 0.596
Tm6sf1
Transmembrane 6 superfamily member 1; May function as sterol isomerase.
      
 0.561
Dhcr24
Delta(24)-sterol reductase; Catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. In addition to its cholesterol-synthesizing activity, can protects cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis (By similarity).
   
 
 0.555
Tsr3
Ribosome biogenesis protein TSR3 homolog; Probable pre-rRNA processing protein involved in ribosome biogenesis.
   
  
 0.554
Sc5d
Lathosterol oxidase; Catalyzes a dehydrogenation to introduce C5-6 double bond into lathosterol.
   
  
 0.545
Plpp5
Phospholipid phosphatase 5; Magnesium-independent phospholipid phosphatase with broad substrate specificity. Preferentially catalyzes the conversion of diacylglycerol pyrophosphate into phosphatidate but can also act on phosphatidate and lysophosphatidate. Phospholipid phosphatases are involved in both the synthesis of lipids and the generation or degradation of lipid-signaling molecules. Belongs to the PA-phosphatase related phosphoesterase family.
   
 
 0.537
Tmem158
Transmembrane protein 158; Receptor for brain injury-derived neurotrophic peptide (BINP), a synthetic 13-mer peptide; Belongs to the TMEM158 family.
      
 0.530
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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