STRINGSTRING
Lcn9 Lcn9 Lcn8 Lcn8 Cst11 Cst11 Lcn12 Lcn12 Lcn5 Lcn5 Gpx5 Gpx5 Lcn6 Lcn6 Adam7 Adam7 Spint4 Spint4 Cst12 Cst12 Cstdc2 Cstdc2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Lcn9Epididymal-specific lipocalin-9. (178 aa)    
Predicted Functional Partners:
Lcn8
Epididymal-specific lipocalin-8; May play a role in male fertility. May act as a retinoid carrier protein within the epididymis.
   
  
 0.956
Cst11
Cystatin-11; Has antibacterial activity against the Gram-negative bacteria E.coli. May play a role in sperm maturation and fertilization. Belongs to the cystatin family.
   
  
 0.927
Lcn12
Epididymal-specific lipocalin-12; Binds all-trans retinoic acid and may act as a retinoid carrier protein within the epididymis. May play a role in male fertility (By similarity); Belongs to the calycin superfamily. Lipocalin family.
   
 
 0.862
Lcn5
Epididymal-specific lipocalin-5, major form; Associates with spermatozoa in the epididymal fluid but does not bind tightly to them. Binds both all-trans and 13-cis retinoic acid. May act as a retinoid carrier protein which is required for epididymal function and/or sperm maturation. Belongs to the calycin superfamily. Lipocalin family.
   
  
 0.822
Gpx5
Epididymal secretory glutathione peroxidase; Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. May constitute a glutathione peroxidase-like protective system against peroxide damage in sperm membrane lipids.
   
  
 0.816
Lcn6
LCN6 isoform alpha; Belongs to the calycin superfamily. Lipocalin family.
   
  
 0.773
Adam7
Disintegrin and metalloproteinase domain-containing protein 7; May play an important role in male reproduction including sperm maturation and gonadotrope function. This is a non catalytic metalloprotease-like protein.
   
  
 0.771
Spint4
Kunitz-type protease inhibitor 4.
   
  
 0.759
Cst12
Cystatin-12; May play a specialized role in spermatogenesis.
   
  
 0.756
Cstdc2
Cystatin domain-containing 2.
   
  
 0.752
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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