STRINGSTRING
Adgrf4 Adgrf4 Adgrg4 Adgrg4 Adgra1 Adgra1 Gtf3c3 Gtf3c3 Wfdc5 Wfdc5 Adgra2 Adgra2 Olfr1362 Olfr1362 Adgra3 Adgra3 Cd2ap Cd2ap Txndc9 Txndc9 9130008F23Rik 9130008F23Rik
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Adgrf4Adhesion G protein-coupled receptor F4; Orphan receptor; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily. (698 aa)    
Predicted Functional Partners:
Adgrg4
Adhesion G-protein coupled receptor G4; Orphan receptor.
      
 0.603
Adgra1
Adhesion G protein-coupled receptor A1; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
   
 
 0.587
Gtf3c3
General transcription factor IIIC, polypeptide 3.
      
 0.571
Wfdc5
WAP four-disulfide core domain 5.
   
  
 0.514
Adgra2
Adhesion G protein-coupled receptor A2; Endothelial receptor which functions together with RECK to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B). Plays a key role in Wnt7-specific responses, such as endothelial cell sprouting and migration in the forebrain and neural tube, and establishment of the blood-brain barrier. Acts as a Wnt7-specific coactivator of canonical Wnt signaling: required to deliver RECK-bound Wnt7 to frizzled by assembling a higher- order RECK-ADGRA2-Fzd-LRP5-LRP6 complex (By similarity). ADGRA2- tethering function does not re [...]
    
 
 0.502
Olfr1362
Olfactory receptor.
      
 0.483
Adgra3
Adhesion G protein-coupled receptor A3; Orphan receptor that may have a role in planar cell polarity pathway.
    
 
 0.482
Cd2ap
CD2-associated protein; Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton (By similarity). In collaboration with CBLC, modulates the rate of RET turnover and may act as regulatory checkpoint that limits the potency of GDNF on neuronal survival. Controls CBLC function, converting it from an inhibitor to a promoter of RET degradation (By similarity). May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen- presenting cell. May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glo [...]
 
    
 0.472
Txndc9
Thioredoxin domain-containing protein 9; Significantly diminishes the chaperonin TCP1 complex ATPase activity, thus negatively impacts protein folding, including that of actin or tubulin.
   
  
 0.464
9130008F23Rik
RIKEN cDNA 9130008F23 gene.
      
 0.457
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.