STRINGSTRING
Dnajc14 Dnajc14 Drd1 Drd1 Nrde2 Nrde2 Pdcl Pdcl Slc26a4 Slc26a4 Gimap8 Gimap8 Stk11ip Stk11ip Spats1 Spats1 Zfp683 Zfp683 Tmub2 Tmub2 Dnajc28 Dnajc28
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Dnajc14DnaJ homolog subfamily C member 14; Regulates the export of target proteins, such as DRD1, from the endoplasmic reticulum to the cell surface. (703 aa)    
Predicted Functional Partners:
Drd1
D(1A) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.
    
 
 0.695
Nrde2
Nuclear exosome regulator NRDE2; Protein of the nuclear speckles that regulates RNA degradation and export from the nucleus through its interaction with MTREX an essential factor directing various RNAs to exosomal degradation. Changes the conformation of MTREX, precluding its association with the nuclear exosome and interaction with proteins required for its function in RNA exosomal degradation. Negatively regulates, for instance, the degradation of mRNAs and lncRNAs by inhibiting their MTREX-mediated recruitment to nuclear exosome. By preventing the degradation of RNAs in the nucleus, [...]
   
  
 0.552
Pdcl
Phosducin-like protein; Functions as a co-chaperone for CCT in the assembly of heterotrimeric G protein complexes, facilitates the assembly of both Gbeta-Ggamma and RGS-Gbeta5 heterodimers. Acts also as a positive regulator of hedgehog signaling and regulates ciliary function ; Belongs to the phosducin family.
   
  
 0.548
Slc26a4
Pendrin; Sodium-independent transporter of chloride and iodide.
      
 0.543
Gimap8
GTPase IMAP family member 8; Exerts an anti-apoptotic effect in the immune system and is involved in responses to infections.
      
 0.541
Stk11ip
Serine/threonine-protein kinase 11-interacting protein; May regulate STK11/LKB1 function by controlling its subcellular localization.
   
  
 0.535
Spats1
Spermatogenesis-associated serine-rich protein 1.
      
 0.513
Zfp683
Tissue-resident T-cell transcription regulator protein ZNF683; Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T-cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long- term establishment of adaptive and innate tissue-resident lymphocyte T- cell types in non-lymphoid or [...]
   
  
 0.498
Tmub2
Transmembrane and ubiquitin-like domain-containing protein 2.
   
  
 0.498
Dnajc28
DnaJ homolog subfamily C member 28; May have a role in protein folding or as a chaperone.
      
 0.496
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
Server load: medium (58%) [ZH]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.