node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Arhgef25 | Stk17b | ENSMUSP00000019611 | ENSMUSP00000027263 | Rho guanine nucleotide exchange factor 25; May play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. It works as a guanine nucleotide exchange factor for Rho family of small GTPases. Links specifically G alpha q/11-coupled receptors to RHOA activation (By similarity). May be an important regulator of processes involved in axon and dendrite formation. In neurons seems to be an exchange factor primarily for RAC1. Involved in skeletal myogenesis. | Serine/threonine-protein kinase 17B; Acts as a positive regulator of apoptosis. Phosphorylates myosin light chains (By similarity); Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily. | 0.822 |
Card14 | Nme5 | ENSMUSP00000101857 | ENSMUSP00000078269 | Caspase recruitment domain-containing protein 14; Acts as a scaffolding protein that can activate the inflammatory transcription factor NF-kappa-B and p38/JNK MAP kinase signaling pathways. Forms a signaling complex with BCL10 and MALT1, and activates MALT1 proteolytic activity and inflammatory gene expression. MALT1 is indispensable for CARD14-induced activation of NF-kappa-B and p38/JNK MAP kinases. May play a role in signaling mediated by TRAF2, TRAF3 and TRAF6 and protects cells against apoptosis. | Nucleoside diphosphate kinase homolog 5; Does not seem to have NDK kinase activity. Confers protection from cell death by Bax and alters the cellular levels of several antioxidant enzymes including Gpx5. May play a role in spermiogenesis by increasing the ability of late-stage spermatids to eliminate reactive oxygen species. | 0.457 |
Card14 | Stk17b | ENSMUSP00000101857 | ENSMUSP00000027263 | Caspase recruitment domain-containing protein 14; Acts as a scaffolding protein that can activate the inflammatory transcription factor NF-kappa-B and p38/JNK MAP kinase signaling pathways. Forms a signaling complex with BCL10 and MALT1, and activates MALT1 proteolytic activity and inflammatory gene expression. MALT1 is indispensable for CARD14-induced activation of NF-kappa-B and p38/JNK MAP kinases. May play a role in signaling mediated by TRAF2, TRAF3 and TRAF6 and protects cells against apoptosis. | Serine/threonine-protein kinase 17B; Acts as a positive regulator of apoptosis. Phosphorylates myosin light chains (By similarity); Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily. | 0.473 |
Cdc7 | Per3 | ENSMUSP00000113385 | ENSMUSP00000099493 | Cell division cycle 7-related protein kinase; Seems to phosphorylate critical substrates that regulate the G1/S phase transition and/or DNA replication. Can phosphorylates MCM2 and MCM3. | Period circadian protein homolog 3; Originally described as a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and [...] | 0.514 |
Cdc7 | Stk17b | ENSMUSP00000113385 | ENSMUSP00000027263 | Cell division cycle 7-related protein kinase; Seems to phosphorylate critical substrates that regulate the G1/S phase transition and/or DNA replication. Can phosphorylates MCM2 and MCM3. | Serine/threonine-protein kinase 17B; Acts as a positive regulator of apoptosis. Phosphorylates myosin light chains (By similarity); Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily. | 0.514 |
Dap | Stk17b | ENSMUSP00000047186 | ENSMUSP00000027263 | Death-associated protein 1; Negative regulator of autophagy. Involved in mediating interferon-gamma-induced cell death (By similarity). | Serine/threonine-protein kinase 17B; Acts as a positive regulator of apoptosis. Phosphorylates myosin light chains (By similarity); Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily. | 0.613 |
Itpr1 | Stk17b | ENSMUSP00000032192 | ENSMUSP00000027263 | Inositol 1,4,5-trisphosphate receptor type 1; Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5- trisphosphate. Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways. | Serine/threonine-protein kinase 17B; Acts as a positive regulator of apoptosis. Phosphorylates myosin light chains (By similarity); Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily. | 0.498 |
Kalrn | Stk17b | ENSMUSP00000110611 | ENSMUSP00000027263 | Kalirin; Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity (By similarity); Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. | Serine/threonine-protein kinase 17B; Acts as a positive regulator of apoptosis. Phosphorylates myosin light chains (By similarity); Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily. | 0.730 |
Nme5 | Card14 | ENSMUSP00000078269 | ENSMUSP00000101857 | Nucleoside diphosphate kinase homolog 5; Does not seem to have NDK kinase activity. Confers protection from cell death by Bax and alters the cellular levels of several antioxidant enzymes including Gpx5. May play a role in spermiogenesis by increasing the ability of late-stage spermatids to eliminate reactive oxygen species. | Caspase recruitment domain-containing protein 14; Acts as a scaffolding protein that can activate the inflammatory transcription factor NF-kappa-B and p38/JNK MAP kinase signaling pathways. Forms a signaling complex with BCL10 and MALT1, and activates MALT1 proteolytic activity and inflammatory gene expression. MALT1 is indispensable for CARD14-induced activation of NF-kappa-B and p38/JNK MAP kinases. May play a role in signaling mediated by TRAF2, TRAF3 and TRAF6 and protects cells against apoptosis. | 0.457 |
Nme5 | Stk17b | ENSMUSP00000078269 | ENSMUSP00000027263 | Nucleoside diphosphate kinase homolog 5; Does not seem to have NDK kinase activity. Confers protection from cell death by Bax and alters the cellular levels of several antioxidant enzymes including Gpx5. May play a role in spermiogenesis by increasing the ability of late-stage spermatids to eliminate reactive oxygen species. | Serine/threonine-protein kinase 17B; Acts as a positive regulator of apoptosis. Phosphorylates myosin light chains (By similarity); Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily. | 0.603 |
Per3 | Cdc7 | ENSMUSP00000099493 | ENSMUSP00000113385 | Period circadian protein homolog 3; Originally described as a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and [...] | Cell division cycle 7-related protein kinase; Seems to phosphorylate critical substrates that regulate the G1/S phase transition and/or DNA replication. Can phosphorylates MCM2 and MCM3. | 0.514 |
Per3 | Stk17b | ENSMUSP00000099493 | ENSMUSP00000027263 | Period circadian protein homolog 3; Originally described as a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and [...] | Serine/threonine-protein kinase 17B; Acts as a positive regulator of apoptosis. Phosphorylates myosin light chains (By similarity); Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily. | 0.470 |
Prkd2 | Prkd3 | ENSMUSP00000083273 | ENSMUSP00000113395 | Serine/threonine-protein kinase D2; Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of cell proliferation via MAPK1/3 (ERK1/2) signaling, oxidative stress-induced NF-kappa-B activation, inhibition of HDAC7 transcriptional repression, signaling downstream of T-cell antigen receptor (TCR) and cytokine production, and plays a role in Golgi membrane trafficking, angiogenesis, secretory granule release and cell adhesion. May potentiate mitogenesis induced by the neu [...] | Serine/threonine-protein kinase D3; Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress (By similarity); Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily. | 0.944 |
Prkd2 | Stk17b | ENSMUSP00000083273 | ENSMUSP00000027263 | Serine/threonine-protein kinase D2; Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of cell proliferation via MAPK1/3 (ERK1/2) signaling, oxidative stress-induced NF-kappa-B activation, inhibition of HDAC7 transcriptional repression, signaling downstream of T-cell antigen receptor (TCR) and cytokine production, and plays a role in Golgi membrane trafficking, angiogenesis, secretory granule release and cell adhesion. May potentiate mitogenesis induced by the neu [...] | Serine/threonine-protein kinase 17B; Acts as a positive regulator of apoptosis. Phosphorylates myosin light chains (By similarity); Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily. | 0.484 |
Prkd3 | Prkd2 | ENSMUSP00000113395 | ENSMUSP00000083273 | Serine/threonine-protein kinase D3; Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress (By similarity); Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily. | Serine/threonine-protein kinase D2; Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of cell proliferation via MAPK1/3 (ERK1/2) signaling, oxidative stress-induced NF-kappa-B activation, inhibition of HDAC7 transcriptional repression, signaling downstream of T-cell antigen receptor (TCR) and cytokine production, and plays a role in Golgi membrane trafficking, angiogenesis, secretory granule release and cell adhesion. May potentiate mitogenesis induced by the neu [...] | 0.944 |
Prkd3 | Stk17b | ENSMUSP00000113395 | ENSMUSP00000027263 | Serine/threonine-protein kinase D3; Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress (By similarity); Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily. | Serine/threonine-protein kinase 17B; Acts as a positive regulator of apoptosis. Phosphorylates myosin light chains (By similarity); Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily. | 0.457 |
Stk17b | Arhgef25 | ENSMUSP00000027263 | ENSMUSP00000019611 | Serine/threonine-protein kinase 17B; Acts as a positive regulator of apoptosis. Phosphorylates myosin light chains (By similarity); Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily. | Rho guanine nucleotide exchange factor 25; May play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. It works as a guanine nucleotide exchange factor for Rho family of small GTPases. Links specifically G alpha q/11-coupled receptors to RHOA activation (By similarity). May be an important regulator of processes involved in axon and dendrite formation. In neurons seems to be an exchange factor primarily for RAC1. Involved in skeletal myogenesis. | 0.822 |
Stk17b | Card14 | ENSMUSP00000027263 | ENSMUSP00000101857 | Serine/threonine-protein kinase 17B; Acts as a positive regulator of apoptosis. Phosphorylates myosin light chains (By similarity); Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily. | Caspase recruitment domain-containing protein 14; Acts as a scaffolding protein that can activate the inflammatory transcription factor NF-kappa-B and p38/JNK MAP kinase signaling pathways. Forms a signaling complex with BCL10 and MALT1, and activates MALT1 proteolytic activity and inflammatory gene expression. MALT1 is indispensable for CARD14-induced activation of NF-kappa-B and p38/JNK MAP kinases. May play a role in signaling mediated by TRAF2, TRAF3 and TRAF6 and protects cells against apoptosis. | 0.473 |
Stk17b | Cdc7 | ENSMUSP00000027263 | ENSMUSP00000113385 | Serine/threonine-protein kinase 17B; Acts as a positive regulator of apoptosis. Phosphorylates myosin light chains (By similarity); Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily. | Cell division cycle 7-related protein kinase; Seems to phosphorylate critical substrates that regulate the G1/S phase transition and/or DNA replication. Can phosphorylates MCM2 and MCM3. | 0.514 |
Stk17b | Dap | ENSMUSP00000027263 | ENSMUSP00000047186 | Serine/threonine-protein kinase 17B; Acts as a positive regulator of apoptosis. Phosphorylates myosin light chains (By similarity); Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily. | Death-associated protein 1; Negative regulator of autophagy. Involved in mediating interferon-gamma-induced cell death (By similarity). | 0.613 |