node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ccdc58 | Tmem63a | ENSMUSP00000125874 | ENSMUSP00000027800 | Coiled-coil domain-containing protein 58; Belongs to the CCDC58 family. | CSC1-like protein 1; Acts as an osmosensitive calcium-permeable cation channel. Mechanosensitive ion channel that converts mechanical stimuli into a flow of ion. Belongs to the CSC1 (TC 1.A.17) family. | 0.418 |
Galm | Tmem147 | ENSMUSP00000040580 | ENSMUSP00000006478 | Aldose 1-epimerase; Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity). | Transmembrane protein 147; Acts as a negative regulator of CHRM3 function, most likely by interfering with its trafficking to the cell membrane (By similarity). Negatively regulates CHRM3-mediated calcium mobilization and activation of RPS6KA1/p90RSK activity (By similarity). | 0.635 |
Galm | Tmem63a | ENSMUSP00000040580 | ENSMUSP00000027800 | Aldose 1-epimerase; Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity). | CSC1-like protein 1; Acts as an osmosensitive calcium-permeable cation channel. Mechanosensitive ion channel that converts mechanical stimuli into a flow of ion. Belongs to the CSC1 (TC 1.A.17) family. | 0.619 |
Ncln | Tmem147 | ENSMUSP00000020463 | ENSMUSP00000006478 | Nicalin; May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning. | Transmembrane protein 147; Acts as a negative regulator of CHRM3 function, most likely by interfering with its trafficking to the cell membrane (By similarity). Negatively regulates CHRM3-mediated calcium mobilization and activation of RPS6KA1/p90RSK activity (By similarity). | 0.933 |
Ncln | Tmem63a | ENSMUSP00000020463 | ENSMUSP00000027800 | Nicalin; May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning. | CSC1-like protein 1; Acts as an osmosensitive calcium-permeable cation channel. Mechanosensitive ion channel that converts mechanical stimuli into a flow of ion. Belongs to the CSC1 (TC 1.A.17) family. | 0.511 |
Sde2 | Tmem63a | ENSMUSP00000037890 | ENSMUSP00000027800 | Replication stress response regulator SDE2; Involved in both DNA replication and cell cycle control. Unprocessed SDE2 interacts with PCNA via its PIP-box. The interaction with PCNA prevents monoubiquitination of the latter thereby inhibiting translesion DNA synthesis. The binding of SDE2 to PCNA also leads to processing of SDE2 by an unidentified deubiquitinating enzyme, cleaving off the N-terminal ubiquitin-like domain. The resulting mature SDE2 is degraded by the DCX(DTL) complex in a cell cycle- and DNA damage dependent manner. Binding of SDE2 to PCNA is necessary to counteract dama [...] | CSC1-like protein 1; Acts as an osmosensitive calcium-permeable cation channel. Mechanosensitive ion channel that converts mechanical stimuli into a flow of ion. Belongs to the CSC1 (TC 1.A.17) family. | 0.477 |
Snx15 | Tmem63a | ENSMUSP00000025702 | ENSMUSP00000027800 | Sorting nexin-15; May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN (By similarity); Belongs to the sorting nexin family. | CSC1-like protein 1; Acts as an osmosensitive calcium-permeable cation channel. Mechanosensitive ion channel that converts mechanical stimuli into a flow of ion. Belongs to the CSC1 (TC 1.A.17) family. | 0.448 |
Tmem120a | Tmem63a | ENSMUSP00000045252 | ENSMUSP00000027800 | Transmembrane protein 120A; Necessary for efficient adipogenesis. | CSC1-like protein 1; Acts as an osmosensitive calcium-permeable cation channel. Mechanosensitive ion channel that converts mechanical stimuli into a flow of ion. Belongs to the CSC1 (TC 1.A.17) family. | 0.521 |
Tmem125 | Tmem63a | ENSMUSP00000063157 | ENSMUSP00000027800 | Transmembrane protein 125. | CSC1-like protein 1; Acts as an osmosensitive calcium-permeable cation channel. Mechanosensitive ion channel that converts mechanical stimuli into a flow of ion. Belongs to the CSC1 (TC 1.A.17) family. | 0.443 |
Tmem147 | Galm | ENSMUSP00000006478 | ENSMUSP00000040580 | Transmembrane protein 147; Acts as a negative regulator of CHRM3 function, most likely by interfering with its trafficking to the cell membrane (By similarity). Negatively regulates CHRM3-mediated calcium mobilization and activation of RPS6KA1/p90RSK activity (By similarity). | Aldose 1-epimerase; Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity). | 0.635 |
Tmem147 | Ncln | ENSMUSP00000006478 | ENSMUSP00000020463 | Transmembrane protein 147; Acts as a negative regulator of CHRM3 function, most likely by interfering with its trafficking to the cell membrane (By similarity). Negatively regulates CHRM3-mediated calcium mobilization and activation of RPS6KA1/p90RSK activity (By similarity). | Nicalin; May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning. | 0.933 |
Tmem147 | Tmem63a | ENSMUSP00000006478 | ENSMUSP00000027800 | Transmembrane protein 147; Acts as a negative regulator of CHRM3 function, most likely by interfering with its trafficking to the cell membrane (By similarity). Negatively regulates CHRM3-mediated calcium mobilization and activation of RPS6KA1/p90RSK activity (By similarity). | CSC1-like protein 1; Acts as an osmosensitive calcium-permeable cation channel. Mechanosensitive ion channel that converts mechanical stimuli into a flow of ion. Belongs to the CSC1 (TC 1.A.17) family. | 0.692 |
Tmem234 | Tmem63a | ENSMUSP00000099651 | ENSMUSP00000027800 | Transmembrane protein 234. | CSC1-like protein 1; Acts as an osmosensitive calcium-permeable cation channel. Mechanosensitive ion channel that converts mechanical stimuli into a flow of ion. Belongs to the CSC1 (TC 1.A.17) family. | 0.525 |
Tmem63a | Ccdc58 | ENSMUSP00000027800 | ENSMUSP00000125874 | CSC1-like protein 1; Acts as an osmosensitive calcium-permeable cation channel. Mechanosensitive ion channel that converts mechanical stimuli into a flow of ion. Belongs to the CSC1 (TC 1.A.17) family. | Coiled-coil domain-containing protein 58; Belongs to the CCDC58 family. | 0.418 |
Tmem63a | Galm | ENSMUSP00000027800 | ENSMUSP00000040580 | CSC1-like protein 1; Acts as an osmosensitive calcium-permeable cation channel. Mechanosensitive ion channel that converts mechanical stimuli into a flow of ion. Belongs to the CSC1 (TC 1.A.17) family. | Aldose 1-epimerase; Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity). | 0.619 |
Tmem63a | Ncln | ENSMUSP00000027800 | ENSMUSP00000020463 | CSC1-like protein 1; Acts as an osmosensitive calcium-permeable cation channel. Mechanosensitive ion channel that converts mechanical stimuli into a flow of ion. Belongs to the CSC1 (TC 1.A.17) family. | Nicalin; May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning. | 0.511 |
Tmem63a | Sde2 | ENSMUSP00000027800 | ENSMUSP00000037890 | CSC1-like protein 1; Acts as an osmosensitive calcium-permeable cation channel. Mechanosensitive ion channel that converts mechanical stimuli into a flow of ion. Belongs to the CSC1 (TC 1.A.17) family. | Replication stress response regulator SDE2; Involved in both DNA replication and cell cycle control. Unprocessed SDE2 interacts with PCNA via its PIP-box. The interaction with PCNA prevents monoubiquitination of the latter thereby inhibiting translesion DNA synthesis. The binding of SDE2 to PCNA also leads to processing of SDE2 by an unidentified deubiquitinating enzyme, cleaving off the N-terminal ubiquitin-like domain. The resulting mature SDE2 is degraded by the DCX(DTL) complex in a cell cycle- and DNA damage dependent manner. Binding of SDE2 to PCNA is necessary to counteract dama [...] | 0.477 |
Tmem63a | Snx15 | ENSMUSP00000027800 | ENSMUSP00000025702 | CSC1-like protein 1; Acts as an osmosensitive calcium-permeable cation channel. Mechanosensitive ion channel that converts mechanical stimuli into a flow of ion. Belongs to the CSC1 (TC 1.A.17) family. | Sorting nexin-15; May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN (By similarity); Belongs to the sorting nexin family. | 0.448 |
Tmem63a | Tmem120a | ENSMUSP00000027800 | ENSMUSP00000045252 | CSC1-like protein 1; Acts as an osmosensitive calcium-permeable cation channel. Mechanosensitive ion channel that converts mechanical stimuli into a flow of ion. Belongs to the CSC1 (TC 1.A.17) family. | Transmembrane protein 120A; Necessary for efficient adipogenesis. | 0.521 |
Tmem63a | Tmem125 | ENSMUSP00000027800 | ENSMUSP00000063157 | CSC1-like protein 1; Acts as an osmosensitive calcium-permeable cation channel. Mechanosensitive ion channel that converts mechanical stimuli into a flow of ion. Belongs to the CSC1 (TC 1.A.17) family. | Transmembrane protein 125. | 0.443 |