STRINGSTRING
Cnn3 Cnn3 Wdr90 Wdr90 Lcp1 Lcp1 Cald1 Cald1 Pdlim4 Pdlim4 Pls3 Pls3 Dstn Dstn Bcl2l10 Bcl2l10 Calb2 Calb2 Calml4 Calml4 Smarca2 Smarca2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Cnn3Calponin-3; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity (By similarity). (330 aa)    
Predicted Functional Partners:
Wdr90
WD repeat-containing protein 90; Required for efficient primary cilium formation.
   
 
 0.772
Lcp1
Plastin-2; Actin-binding protein. Plays a role in the activation of T- cells in response to costimulation through TCR/CD3 and CD2 or CD28. Modulates the cell surface expression of IL2RA/CD25 and CD69.
   
 
 0.632
Cald1
Caldesmon 1.
   
 
 0.602
Pdlim4
PDZ and LIM domain protein 4; Suppresses SRC activation by recognizing and binding to active SRC and facilitating PTPN13-mediated dephosphorylation of SRC 'Tyr-419' leading to its inactivation. Inactivated SRC dissociates from this protein allowing the initiation of a new SRC inactivation cycle. Involved in reorganization of the actin cytoskeleton (By similarity). In nonmuscle cells, binds to ACTN1 (alpha-actinin-1), increases the affinity of ACTN1 to F-actin (filamentous actin), and promotes formation of actin stress fibers. Involved in regulation of the synaptic AMPA receptor transpo [...]
   
 
 0.590
Pls3
Plastin-3; Actin-bundling protein.
   
 
 0.586
Dstn
Destrin; Actin-depolymerizing protein. Severs actin filaments (F- actin) and binds to actin monomers (G-actin). Acts in a pH-independent manner; Belongs to the actin-binding proteins ADF family.
   
 
 0.585
Bcl2l10
Bcl-2-like protein 10; Promotes cell survival. Suppresses apoptosis; Belongs to the Bcl-2 family.
   
  
 0.572
Calb2
Calretinin; Calretinin is a calcium-binding protein which is abundant in auditory neurons.
   
 
 0.553
Calml4
Calmodulin-like protein 4.
   
 
 0.549
Smarca2
Probable global transcription activator SNF2L2; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural develop [...]
   
  
 0.540
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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