node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cyb5r4 | Cyp2w1 | ENSMUSP00000126119 | ENSMUSP00000031521 | Cytochrome b5 reductase 4; NADH-cytochrome b5 reductase involved in endoplasmic reticulum stress response pathway. Plays a critical role in protecting pancreatic beta-cells against oxidant stress, possibly by protecting the cell from excess buildup of reactive oxygen species (ROS). | Cytochrome P450 2W1; Seems to have broad catalytic activity towards several chemicals, including polycyclic aromatic hydrocarbon dihydrodiols and aromatic amines. Active also in the metabolism of indoline substrates and is able to activate aflatoxin B1 into cytotoxic products. Furthermore, it seems to be involved in the oxydation of lysophospholipids and fatty acids. | 0.413 |
Cyb5r4 | Cyp7b1 | ENSMUSP00000126119 | ENSMUSP00000037487 | Cytochrome b5 reductase 4; NADH-cytochrome b5 reductase involved in endoplasmic reticulum stress response pathway. Plays a critical role in protecting pancreatic beta-cells against oxidant stress, possibly by protecting the cell from excess buildup of reactive oxygen species (ROS). | Cytochrome P450 7B1; A cytochrome P450 monooxygenase involved in the metabolism of endogenous oxysterols and steroid hormones, including neurosteroids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH- ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds of steroids with a preference for 7-alpha position. Usually metabolizes steroids carrying a hydroxy group at position 3, functioning as a 3-hydroxy [...] | 0.497 |
Cyb5r4 | Ppig | ENSMUSP00000126119 | ENSMUSP00000045945 | Cytochrome b5 reductase 4; NADH-cytochrome b5 reductase involved in endoplasmic reticulum stress response pathway. Plays a critical role in protecting pancreatic beta-cells against oxidant stress, possibly by protecting the cell from excess buildup of reactive oxygen species (ROS). | Peptidyl-prolyl cis-trans isomerase G; PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. May be implicated in the folding, transport, and assembly of proteins. May play an important role in the regulation of pre-mRNA splicing. | 0.445 |
Cyp2c65 | Cyp2c66 | ENSMUSP00000084489 | ENSMUSP00000084487 | Cytochrome P450, family 2, subfamily c, polypeptide 65; Belongs to the cytochrome P450 family. | Cytochrome P450, family 2, subfamily c, polypeptide 66; Belongs to the cytochrome P450 family. | 0.755 |
Cyp2c65 | Cyp2d22 | ENSMUSP00000084489 | ENSMUSP00000023083 | Cytochrome P450, family 2, subfamily c, polypeptide 65; Belongs to the cytochrome P450 family. | Cytochrome P450, family 2, subfamily d, polypeptide 22; Belongs to the cytochrome P450 family. | 0.467 |
Cyp2c65 | Cyp2e1 | ENSMUSP00000084489 | ENSMUSP00000026552 | Cytochrome P450, family 2, subfamily c, polypeptide 65; Belongs to the cytochrome P450 family. | Cytochrome P450 2E1; A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics. | 0.904 |
Cyp2c65 | Cyp2j6 | ENSMUSP00000084489 | ENSMUSP00000030303 | Cytochrome P450, family 2, subfamily c, polypeptide 65; Belongs to the cytochrome P450 family. | Cytochrome P450 2J6. | 0.686 |
Cyp2c65 | Cyp2w1 | ENSMUSP00000084489 | ENSMUSP00000031521 | Cytochrome P450, family 2, subfamily c, polypeptide 65; Belongs to the cytochrome P450 family. | Cytochrome P450 2W1; Seems to have broad catalytic activity towards several chemicals, including polycyclic aromatic hydrocarbon dihydrodiols and aromatic amines. Active also in the metabolism of indoline substrates and is able to activate aflatoxin B1 into cytotoxic products. Furthermore, it seems to be involved in the oxydation of lysophospholipids and fatty acids. | 0.444 |
Cyp2c65 | Cyp39a1 | ENSMUSP00000084489 | ENSMUSP00000130073 | Cytochrome P450, family 2, subfamily c, polypeptide 65; Belongs to the cytochrome P450 family. | 24-hydroxycholesterol 7-alpha-hydroxylase; A cytochrome P450 monooxygenase involved in neural cholesterol clearance through bile acid synthesis. Catalyzes 7-alpha hydroxylation of (24S)-hydroxycholesterol, a neural oxysterol that is metabolized to bile acids in the liver. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH- ferrihemoprotein reductase). | 0.418 |
Cyp2c65 | Cyp7a1 | ENSMUSP00000084489 | ENSMUSP00000029905 | Cytochrome P450, family 2, subfamily c, polypeptide 65; Belongs to the cytochrome P450 family. | Cytochrome P450 7A1; A cytochrome P450 monooxygenase involved in the metabolism of endogenous cholesterol and its oxygenated derivatives (oxysterols) (By similarity). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (By similarity). Functions as a critical regulatory enzyme of bile acid biosynthesis and cholesterol homeostasis. Catalyzes the hydroxylation of carbon hydrogen bond at 7-alpha position of [...] | 0.772 |
Cyp2c65 | Cyp7b1 | ENSMUSP00000084489 | ENSMUSP00000037487 | Cytochrome P450, family 2, subfamily c, polypeptide 65; Belongs to the cytochrome P450 family. | Cytochrome P450 7B1; A cytochrome P450 monooxygenase involved in the metabolism of endogenous oxysterols and steroid hormones, including neurosteroids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH- ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds of steroids with a preference for 7-alpha position. Usually metabolizes steroids carrying a hydroxy group at position 3, functioning as a 3-hydroxy [...] | 0.493 |
Cyp2c66 | Cyp2c65 | ENSMUSP00000084487 | ENSMUSP00000084489 | Cytochrome P450, family 2, subfamily c, polypeptide 66; Belongs to the cytochrome P450 family. | Cytochrome P450, family 2, subfamily c, polypeptide 65; Belongs to the cytochrome P450 family. | 0.755 |
Cyp2c66 | Cyp2d22 | ENSMUSP00000084487 | ENSMUSP00000023083 | Cytochrome P450, family 2, subfamily c, polypeptide 66; Belongs to the cytochrome P450 family. | Cytochrome P450, family 2, subfamily d, polypeptide 22; Belongs to the cytochrome P450 family. | 0.456 |
Cyp2c66 | Cyp2e1 | ENSMUSP00000084487 | ENSMUSP00000026552 | Cytochrome P450, family 2, subfamily c, polypeptide 66; Belongs to the cytochrome P450 family. | Cytochrome P450 2E1; A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics. | 0.904 |
Cyp2c66 | Cyp2j6 | ENSMUSP00000084487 | ENSMUSP00000030303 | Cytochrome P450, family 2, subfamily c, polypeptide 66; Belongs to the cytochrome P450 family. | Cytochrome P450 2J6. | 0.676 |
Cyp2c66 | Cyp2w1 | ENSMUSP00000084487 | ENSMUSP00000031521 | Cytochrome P450, family 2, subfamily c, polypeptide 66; Belongs to the cytochrome P450 family. | Cytochrome P450 2W1; Seems to have broad catalytic activity towards several chemicals, including polycyclic aromatic hydrocarbon dihydrodiols and aromatic amines. Active also in the metabolism of indoline substrates and is able to activate aflatoxin B1 into cytotoxic products. Furthermore, it seems to be involved in the oxydation of lysophospholipids and fatty acids. | 0.434 |
Cyp2c66 | Cyp7a1 | ENSMUSP00000084487 | ENSMUSP00000029905 | Cytochrome P450, family 2, subfamily c, polypeptide 66; Belongs to the cytochrome P450 family. | Cytochrome P450 7A1; A cytochrome P450 monooxygenase involved in the metabolism of endogenous cholesterol and its oxygenated derivatives (oxysterols) (By similarity). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (By similarity). Functions as a critical regulatory enzyme of bile acid biosynthesis and cholesterol homeostasis. Catalyzes the hydroxylation of carbon hydrogen bond at 7-alpha position of [...] | 0.770 |
Cyp2c66 | Cyp7b1 | ENSMUSP00000084487 | ENSMUSP00000037487 | Cytochrome P450, family 2, subfamily c, polypeptide 66; Belongs to the cytochrome P450 family. | Cytochrome P450 7B1; A cytochrome P450 monooxygenase involved in the metabolism of endogenous oxysterols and steroid hormones, including neurosteroids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH- ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds of steroids with a preference for 7-alpha position. Usually metabolizes steroids carrying a hydroxy group at position 3, functioning as a 3-hydroxy [...] | 0.426 |
Cyp2d22 | Cyp2c65 | ENSMUSP00000023083 | ENSMUSP00000084489 | Cytochrome P450, family 2, subfamily d, polypeptide 22; Belongs to the cytochrome P450 family. | Cytochrome P450, family 2, subfamily c, polypeptide 65; Belongs to the cytochrome P450 family. | 0.467 |
Cyp2d22 | Cyp2c66 | ENSMUSP00000023083 | ENSMUSP00000084487 | Cytochrome P450, family 2, subfamily d, polypeptide 22; Belongs to the cytochrome P450 family. | Cytochrome P450, family 2, subfamily c, polypeptide 66; Belongs to the cytochrome P450 family. | 0.456 |