node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Mtx1 | Samm50 | ENSMUSP00000073261 | ENSMUSP00000023071 | Metaxin-1; Involved in transport of proteins into the mitochondrion. Essential for embryonic development. | Sorting and assembly machinery component 50 homolog; Plays a crucial role in the maintenance of the structure of mitochondrial cristae and the proper assembly of the mitochondrial respiratory chain complexes. Required for the assembly of TOMM40 into the TOM complex; Belongs to the SAM50/omp85 family. | 0.986 |
Mtx1 | Timm50 | ENSMUSP00000073261 | ENSMUSP00000080614 | Metaxin-1; Involved in transport of proteins into the mitochondrion. Essential for embryonic development. | Mitochondrial import inner membrane translocase subunit TIM50; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Has some phosphatase activity in vitro; however such activity may not be relevant in vivo. | 0.659 |
Mtx1 | Tomm20 | ENSMUSP00000073261 | ENSMUSP00000136493 | Metaxin-1; Involved in transport of proteins into the mitochondrion. Essential for embryonic development. | Mitochondrial import receptor subunit TOM20 homolog; Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore (By similarity). Required for the translocation across the mitochondrial outer membrane of cytochrome P450 monooxygenases. | 0.810 |
Mtx1 | Tomm22 | ENSMUSP00000073261 | ENSMUSP00000023062 | Metaxin-1; Involved in transport of proteins into the mitochondrion. Essential for embryonic development. | Mitochondrial import receptor subunit TOM22 homolog; Central receptor component of the translocase of the outer membrane of mitochondria (TOM complex) responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with the peripheral receptor TOM20 functions as the transit peptide receptor and facilitates the movement of preproteins into the translocation pore (By similarity). Required for the translocation across the mitochondrial outer membrane of cytochrome P450 monooxygenases (By similarity); Belongs to the Tom22 family. | 0.947 |
Mtx1 | Tomm40 | ENSMUSP00000073261 | ENSMUSP00000032555 | Metaxin-1; Involved in transport of proteins into the mitochondrion. Essential for embryonic development. | Mitochondrial import receptor subunit TOM40 homolog; Channel-forming protein essential for import of protein precursors into mitochondria. | 0.963 |
Mtx1 | Tomm5 | ENSMUSP00000073261 | ENSMUSP00000103438 | Metaxin-1; Involved in transport of proteins into the mitochondrion. Essential for embryonic development. | Mitochondrial import receptor subunit TOM5 homolog. | 0.831 |
Mtx1 | Tomm6 | ENSMUSP00000073261 | ENSMUSP00000108927 | Metaxin-1; Involved in transport of proteins into the mitochondrion. Essential for embryonic development. | Mitochondrial import receptor subunit TOM6 homolog; Belongs to the Tom6 family. | 0.551 |
Mtx1 | Tomm7 | ENSMUSP00000073261 | ENSMUSP00000030851 | Metaxin-1; Involved in transport of proteins into the mitochondrion. Essential for embryonic development. | Mitochondrial import receptor subunit TOM7 homolog; Required for assembly and stability of the TOM complex (By similarity). Positive regulator of PRKN translocation to damaged mitochondria. Acts probably by stabilizing PINK1 on the outer membrane of depolarized mitochondria (By similarity). | 0.893 |
Mtx1 | Tomm70a | ENSMUSP00000073261 | ENSMUSP00000129186 | Metaxin-1; Involved in transport of proteins into the mitochondrion. Essential for embryonic development. | Mitochondrial import receptor subunit TOM70; Receptor that accelerates the import of all mitochondrial precursor proteins. | 0.910 |
Samm50 | Mtx1 | ENSMUSP00000023071 | ENSMUSP00000073261 | Sorting and assembly machinery component 50 homolog; Plays a crucial role in the maintenance of the structure of mitochondrial cristae and the proper assembly of the mitochondrial respiratory chain complexes. Required for the assembly of TOMM40 into the TOM complex; Belongs to the SAM50/omp85 family. | Metaxin-1; Involved in transport of proteins into the mitochondrion. Essential for embryonic development. | 0.986 |
Samm50 | Timm50 | ENSMUSP00000023071 | ENSMUSP00000080614 | Sorting and assembly machinery component 50 homolog; Plays a crucial role in the maintenance of the structure of mitochondrial cristae and the proper assembly of the mitochondrial respiratory chain complexes. Required for the assembly of TOMM40 into the TOM complex; Belongs to the SAM50/omp85 family. | Mitochondrial import inner membrane translocase subunit TIM50; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Has some phosphatase activity in vitro; however such activity may not be relevant in vivo. | 0.616 |
Samm50 | Tomm20 | ENSMUSP00000023071 | ENSMUSP00000136493 | Sorting and assembly machinery component 50 homolog; Plays a crucial role in the maintenance of the structure of mitochondrial cristae and the proper assembly of the mitochondrial respiratory chain complexes. Required for the assembly of TOMM40 into the TOM complex; Belongs to the SAM50/omp85 family. | Mitochondrial import receptor subunit TOM20 homolog; Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore (By similarity). Required for the translocation across the mitochondrial outer membrane of cytochrome P450 monooxygenases. | 0.812 |
Samm50 | Tomm22 | ENSMUSP00000023071 | ENSMUSP00000023062 | Sorting and assembly machinery component 50 homolog; Plays a crucial role in the maintenance of the structure of mitochondrial cristae and the proper assembly of the mitochondrial respiratory chain complexes. Required for the assembly of TOMM40 into the TOM complex; Belongs to the SAM50/omp85 family. | Mitochondrial import receptor subunit TOM22 homolog; Central receptor component of the translocase of the outer membrane of mitochondria (TOM complex) responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with the peripheral receptor TOM20 functions as the transit peptide receptor and facilitates the movement of preproteins into the translocation pore (By similarity). Required for the translocation across the mitochondrial outer membrane of cytochrome P450 monooxygenases (By similarity); Belongs to the Tom22 family. | 0.980 |
Samm50 | Tomm40 | ENSMUSP00000023071 | ENSMUSP00000032555 | Sorting and assembly machinery component 50 homolog; Plays a crucial role in the maintenance of the structure of mitochondrial cristae and the proper assembly of the mitochondrial respiratory chain complexes. Required for the assembly of TOMM40 into the TOM complex; Belongs to the SAM50/omp85 family. | Mitochondrial import receptor subunit TOM40 homolog; Channel-forming protein essential for import of protein precursors into mitochondria. | 0.983 |
Samm50 | Tomm5 | ENSMUSP00000023071 | ENSMUSP00000103438 | Sorting and assembly machinery component 50 homolog; Plays a crucial role in the maintenance of the structure of mitochondrial cristae and the proper assembly of the mitochondrial respiratory chain complexes. Required for the assembly of TOMM40 into the TOM complex; Belongs to the SAM50/omp85 family. | Mitochondrial import receptor subunit TOM5 homolog. | 0.766 |
Samm50 | Tomm6 | ENSMUSP00000023071 | ENSMUSP00000108927 | Sorting and assembly machinery component 50 homolog; Plays a crucial role in the maintenance of the structure of mitochondrial cristae and the proper assembly of the mitochondrial respiratory chain complexes. Required for the assembly of TOMM40 into the TOM complex; Belongs to the SAM50/omp85 family. | Mitochondrial import receptor subunit TOM6 homolog; Belongs to the Tom6 family. | 0.462 |
Samm50 | Tomm7 | ENSMUSP00000023071 | ENSMUSP00000030851 | Sorting and assembly machinery component 50 homolog; Plays a crucial role in the maintenance of the structure of mitochondrial cristae and the proper assembly of the mitochondrial respiratory chain complexes. Required for the assembly of TOMM40 into the TOM complex; Belongs to the SAM50/omp85 family. | Mitochondrial import receptor subunit TOM7 homolog; Required for assembly and stability of the TOM complex (By similarity). Positive regulator of PRKN translocation to damaged mitochondria. Acts probably by stabilizing PINK1 on the outer membrane of depolarized mitochondria (By similarity). | 0.895 |
Samm50 | Tomm70a | ENSMUSP00000023071 | ENSMUSP00000129186 | Sorting and assembly machinery component 50 homolog; Plays a crucial role in the maintenance of the structure of mitochondrial cristae and the proper assembly of the mitochondrial respiratory chain complexes. Required for the assembly of TOMM40 into the TOM complex; Belongs to the SAM50/omp85 family. | Mitochondrial import receptor subunit TOM70; Receptor that accelerates the import of all mitochondrial precursor proteins. | 0.907 |
Sod1 | Tomm20 | ENSMUSP00000023707 | ENSMUSP00000136493 | Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family. | Mitochondrial import receptor subunit TOM20 homolog; Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore (By similarity). Required for the translocation across the mitochondrial outer membrane of cytochrome P450 monooxygenases. | 0.513 |
Sod1 | Tomm40 | ENSMUSP00000023707 | ENSMUSP00000032555 | Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family. | Mitochondrial import receptor subunit TOM40 homolog; Channel-forming protein essential for import of protein precursors into mitochondria. | 0.922 |