node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Atox1 | Atp7a | ENSMUSP00000104485 | ENSMUSP00000058840 | Copper transport protein ATOX1; Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense (By similarity); Belongs to the ATX1 family. | Copper-transporting ATPase 1; May supply copper to copper-requiring proteins within the secretory pathway, when localized in the trans-Golgi network. Under conditions of elevated extracellular copper, it relocalized to the plasma membrane where it functions in the efflux of copper from cells (By similarity); Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily. | 0.998 |
Atox1 | Atp7b | ENSMUSP00000104485 | ENSMUSP00000006742 | Copper transport protein ATOX1; Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense (By similarity); Belongs to the ATX1 family. | Copper-transporting ATPase 2; Copper ion transmembrane transporter involved in the export of copper out of the cells, such as the efflux of hepatic copper into the bile. | 0.997 |
Atox1 | Mt3 | ENSMUSP00000104485 | ENSMUSP00000034211 | Copper transport protein ATOX1; Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense (By similarity); Belongs to the ATX1 family. | Metallothionein-3; Binds heavy metals. Contains three zinc and three copper atoms per polypeptide chain and only a negligible amount of cadmium. Inhibits survival and neurite formation of cortical neurons in vitro (By similarity); Belongs to the metallothionein superfamily. Type 1 family. | 0.453 |
Atox1 | Mt4 | ENSMUSP00000104485 | ENSMUSP00000034207 | Copper transport protein ATOX1; Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense (By similarity); Belongs to the ATX1 family. | Metallothionein-4; Seems to bind zinc and copper. Could play a special role in regulating zinc metabolism during the differentiation of stratified epithelia; Belongs to the metallothionein superfamily. Type 1 family. | 0.605 |
Atp7a | Atox1 | ENSMUSP00000058840 | ENSMUSP00000104485 | Copper-transporting ATPase 1; May supply copper to copper-requiring proteins within the secretory pathway, when localized in the trans-Golgi network. Under conditions of elevated extracellular copper, it relocalized to the plasma membrane where it functions in the efflux of copper from cells (By similarity); Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily. | Copper transport protein ATOX1; Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense (By similarity); Belongs to the ATX1 family. | 0.998 |
Atp7a | Atp7b | ENSMUSP00000058840 | ENSMUSP00000006742 | Copper-transporting ATPase 1; May supply copper to copper-requiring proteins within the secretory pathway, when localized in the trans-Golgi network. Under conditions of elevated extracellular copper, it relocalized to the plasma membrane where it functions in the efflux of copper from cells (By similarity); Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily. | Copper-transporting ATPase 2; Copper ion transmembrane transporter involved in the export of copper out of the cells, such as the efflux of hepatic copper into the bile. | 0.905 |
Atp7a | Mt4 | ENSMUSP00000058840 | ENSMUSP00000034207 | Copper-transporting ATPase 1; May supply copper to copper-requiring proteins within the secretory pathway, when localized in the trans-Golgi network. Under conditions of elevated extracellular copper, it relocalized to the plasma membrane where it functions in the efflux of copper from cells (By similarity); Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily. | Metallothionein-4; Seems to bind zinc and copper. Could play a special role in regulating zinc metabolism during the differentiation of stratified epithelia; Belongs to the metallothionein superfamily. Type 1 family. | 0.586 |
Atp7b | Atox1 | ENSMUSP00000006742 | ENSMUSP00000104485 | Copper-transporting ATPase 2; Copper ion transmembrane transporter involved in the export of copper out of the cells, such as the efflux of hepatic copper into the bile. | Copper transport protein ATOX1; Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense (By similarity); Belongs to the ATX1 family. | 0.997 |
Atp7b | Atp7a | ENSMUSP00000006742 | ENSMUSP00000058840 | Copper-transporting ATPase 2; Copper ion transmembrane transporter involved in the export of copper out of the cells, such as the efflux of hepatic copper into the bile. | Copper-transporting ATPase 1; May supply copper to copper-requiring proteins within the secretory pathway, when localized in the trans-Golgi network. Under conditions of elevated extracellular copper, it relocalized to the plasma membrane where it functions in the efflux of copper from cells (By similarity); Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily. | 0.905 |
Atp7b | Mt4 | ENSMUSP00000006742 | ENSMUSP00000034207 | Copper-transporting ATPase 2; Copper ion transmembrane transporter involved in the export of copper out of the cells, such as the efflux of hepatic copper into the bile. | Metallothionein-4; Seems to bind zinc and copper. Could play a special role in regulating zinc metabolism during the differentiation of stratified epithelia; Belongs to the metallothionein superfamily. Type 1 family. | 0.597 |
Gpx1 | Gpx2 | ENSMUSP00000081010 | ENSMUSP00000081012 | Glutathione peroxidase 1; Protects the hemoglobin in erythrocytes from oxidative breakdown. | Glutathione peroxidase 2. | 0.425 |
Gpx1 | Mt4 | ENSMUSP00000081010 | ENSMUSP00000034207 | Glutathione peroxidase 1; Protects the hemoglobin in erythrocytes from oxidative breakdown. | Metallothionein-4; Seems to bind zinc and copper. Could play a special role in regulating zinc metabolism during the differentiation of stratified epithelia; Belongs to the metallothionein superfamily. Type 1 family. | 0.598 |
Gpx2 | Gpx1 | ENSMUSP00000081012 | ENSMUSP00000081010 | Glutathione peroxidase 2. | Glutathione peroxidase 1; Protects the hemoglobin in erythrocytes from oxidative breakdown. | 0.425 |
Gpx2 | Mt4 | ENSMUSP00000081012 | ENSMUSP00000034207 | Glutathione peroxidase 2. | Metallothionein-4; Seems to bind zinc and copper. Could play a special role in regulating zinc metabolism during the differentiation of stratified epithelia; Belongs to the metallothionein superfamily. Type 1 family. | 0.609 |
Gpx3 | Mt4 | ENSMUSP00000081011 | ENSMUSP00000034207 | Glutathione peroxidase 3; Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. | Metallothionein-4; Seems to bind zinc and copper. Could play a special role in regulating zinc metabolism during the differentiation of stratified epithelia; Belongs to the metallothionein superfamily. Type 1 family. | 0.601 |
Gpx5 | Mt4 | ENSMUSP00000106117 | ENSMUSP00000034207 | Epididymal secretory glutathione peroxidase; Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. May constitute a glutathione peroxidase-like protective system against peroxide damage in sperm membrane lipids. | Metallothionein-4; Seems to bind zinc and copper. Could play a special role in regulating zinc metabolism during the differentiation of stratified epithelia; Belongs to the metallothionein superfamily. Type 1 family. | 0.605 |
Gpx6 | Mt4 | ENSMUSP00000004453 | ENSMUSP00000034207 | Glutathione peroxidase 6; Belongs to the glutathione peroxidase family. | Metallothionein-4; Seems to bind zinc and copper. Could play a special role in regulating zinc metabolism during the differentiation of stratified epithelia; Belongs to the metallothionein superfamily. Type 1 family. | 0.613 |
Gpx7 | Mt4 | ENSMUSP00000030332 | ENSMUSP00000034207 | Glutathione peroxidase 7; It protects esophageal epithelia from hydrogen peroxide- induced oxidative stress. It suppresses acidic bile acid-induced reactive oxigen species (ROS) and protects against oxidative DNA damage and double-strand breaks (By similarity). | Metallothionein-4; Seems to bind zinc and copper. Could play a special role in regulating zinc metabolism during the differentiation of stratified epithelia; Belongs to the metallothionein superfamily. Type 1 family. | 0.604 |
Mt3 | Atox1 | ENSMUSP00000034211 | ENSMUSP00000104485 | Metallothionein-3; Binds heavy metals. Contains three zinc and three copper atoms per polypeptide chain and only a negligible amount of cadmium. Inhibits survival and neurite formation of cortical neurons in vitro (By similarity); Belongs to the metallothionein superfamily. Type 1 family. | Copper transport protein ATOX1; Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense (By similarity); Belongs to the ATX1 family. | 0.453 |
Mt3 | Mt4 | ENSMUSP00000034211 | ENSMUSP00000034207 | Metallothionein-3; Binds heavy metals. Contains three zinc and three copper atoms per polypeptide chain and only a negligible amount of cadmium. Inhibits survival and neurite formation of cortical neurons in vitro (By similarity); Belongs to the metallothionein superfamily. Type 1 family. | Metallothionein-4; Seems to bind zinc and copper. Could play a special role in regulating zinc metabolism during the differentiation of stratified epithelia; Belongs to the metallothionein superfamily. Type 1 family. | 0.891 |