node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Bsx | Jhy | ENSMUSP00000068057 | ENSMUSP00000034521 | Brain-specific homeobox protein homolog; DNA binding protein that function as transcriptional activator. Is essential for normal postnatal growth and nursing. Is an essential factor for neuronal neuropeptide Y and agouti-related peptide function and locomotory behavior in the control of energy balance. Belongs to the distal-less homeobox family. | Jhy protein; Required for the normal development of cilia in brain ependymal cells lining the ventricular surfaces. | 0.410 |
Ccdc39 | Jhy | ENSMUSP00000029222 | ENSMUSP00000034521 | Coiled-coil domain-containing protein 39; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with CCDC40 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella. Not required for outer dynein arm complexes assembly. | Jhy protein; Required for the normal development of cilia in brain ependymal cells lining the ventricular surfaces. | 0.587 |
Ccdc39 | Lrrc6 | ENSMUSP00000029222 | ENSMUSP00000023006 | Coiled-coil domain-containing protein 39; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with CCDC40 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella. Not required for outer dynein arm complexes assembly. | Protein tilB homolog; May play a role in dynein arm assembly, hence essential for proper axoneme building for cilia motility; Belongs to the tilB family. | 0.807 |
Ccdc39 | Rsph3a | ENSMUSP00000029222 | ENSMUSP00000095034 | Coiled-coil domain-containing protein 39; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with CCDC40 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella. Not required for outer dynein arm complexes assembly. | Radial spoke head protein 3 homolog A; Functions as a protein kinase A-anchoring protein that scaffolds the cAMP-dependent protein kinase holoenzyme. May serve as a point of convergence for MAPK and PKA signaling in cilia (By similarity). | 0.447 |
Ccdc39 | Rsph9 | ENSMUSP00000029222 | ENSMUSP00000024762 | Coiled-coil domain-containing protein 39; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with CCDC40 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella. Not required for outer dynein arm complexes assembly. | Radial spoke head protein 9 homolog; Probable component of the axonemal radial spoke head (By similarity). Radial spokes are regularly spaced along cilia, sperm and flagella axonemes. They consist of a thin stalk, which is attached to a subfiber of the outer doublet microtubule, and a bulbous head, which is attached to the stalk and appears to interact with the projections from the central pair of microtubules. | 0.832 |
Ccdc39 | Zmynd10 | ENSMUSP00000029222 | ENSMUSP00000010188 | Coiled-coil domain-containing protein 39; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with CCDC40 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella. Not required for outer dynein arm complexes assembly. | Zinc finger MYND domain-containing protein 10; Plays a role in axonemal structure organization and motility. Involved in axonemal pre-assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility. May act by indirectly regulating transcription of dynein proteins (By similarity); Belongs to the ZMYND10 family. | 0.790 |
Jhy | Bsx | ENSMUSP00000034521 | ENSMUSP00000068057 | Jhy protein; Required for the normal development of cilia in brain ependymal cells lining the ventricular surfaces. | Brain-specific homeobox protein homolog; DNA binding protein that function as transcriptional activator. Is essential for normal postnatal growth and nursing. Is an essential factor for neuronal neuropeptide Y and agouti-related peptide function and locomotory behavior in the control of energy balance. Belongs to the distal-less homeobox family. | 0.410 |
Jhy | Ccdc39 | ENSMUSP00000034521 | ENSMUSP00000029222 | Jhy protein; Required for the normal development of cilia in brain ependymal cells lining the ventricular surfaces. | Coiled-coil domain-containing protein 39; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with CCDC40 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella. Not required for outer dynein arm complexes assembly. | 0.587 |
Jhy | Lrrc6 | ENSMUSP00000034521 | ENSMUSP00000023006 | Jhy protein; Required for the normal development of cilia in brain ependymal cells lining the ventricular surfaces. | Protein tilB homolog; May play a role in dynein arm assembly, hence essential for proper axoneme building for cilia motility; Belongs to the tilB family. | 0.610 |
Jhy | Rsph3a | ENSMUSP00000034521 | ENSMUSP00000095034 | Jhy protein; Required for the normal development of cilia in brain ependymal cells lining the ventricular surfaces. | Radial spoke head protein 3 homolog A; Functions as a protein kinase A-anchoring protein that scaffolds the cAMP-dependent protein kinase holoenzyme. May serve as a point of convergence for MAPK and PKA signaling in cilia (By similarity). | 0.454 |
Jhy | Rsph9 | ENSMUSP00000034521 | ENSMUSP00000024762 | Jhy protein; Required for the normal development of cilia in brain ependymal cells lining the ventricular surfaces. | Radial spoke head protein 9 homolog; Probable component of the axonemal radial spoke head (By similarity). Radial spokes are regularly spaced along cilia, sperm and flagella axonemes. They consist of a thin stalk, which is attached to a subfiber of the outer doublet microtubule, and a bulbous head, which is attached to the stalk and appears to interact with the projections from the central pair of microtubules. | 0.646 |
Jhy | Sh2d5 | ENSMUSP00000034521 | ENSMUSP00000101449 | Jhy protein; Required for the normal development of cilia in brain ependymal cells lining the ventricular surfaces. | SH2 domain-containing protein 5; May be involved in synaptic plasticity regulation through the control of Rac-GTP levels. | 0.478 |
Jhy | Uap1l1 | ENSMUSP00000034521 | ENSMUSP00000099989 | Jhy protein; Required for the normal development of cilia in brain ependymal cells lining the ventricular surfaces. | UDP-N-acetylhexosamine pyrophosphorylase-like protein 1. | 0.436 |
Jhy | Ulk4 | ENSMUSP00000034521 | ENSMUSP00000131342 | Jhy protein; Required for the normal development of cilia in brain ependymal cells lining the ventricular surfaces. | Serine/threonine-protein kinase ULK4; May be involved in the remodeling of cytoskeletal components, such as alpha-tubulin, and in this way regulates neurite branching and elongation, as well as cell motility; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. | 0.571 |
Jhy | Zmynd10 | ENSMUSP00000034521 | ENSMUSP00000010188 | Jhy protein; Required for the normal development of cilia in brain ependymal cells lining the ventricular surfaces. | Zinc finger MYND domain-containing protein 10; Plays a role in axonemal structure organization and motility. Involved in axonemal pre-assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility. May act by indirectly regulating transcription of dynein proteins (By similarity); Belongs to the ZMYND10 family. | 0.659 |
Lrrc6 | Ccdc39 | ENSMUSP00000023006 | ENSMUSP00000029222 | Protein tilB homolog; May play a role in dynein arm assembly, hence essential for proper axoneme building for cilia motility; Belongs to the tilB family. | Coiled-coil domain-containing protein 39; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with CCDC40 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella. Not required for outer dynein arm complexes assembly. | 0.807 |
Lrrc6 | Jhy | ENSMUSP00000023006 | ENSMUSP00000034521 | Protein tilB homolog; May play a role in dynein arm assembly, hence essential for proper axoneme building for cilia motility; Belongs to the tilB family. | Jhy protein; Required for the normal development of cilia in brain ependymal cells lining the ventricular surfaces. | 0.610 |
Lrrc6 | Rsph9 | ENSMUSP00000023006 | ENSMUSP00000024762 | Protein tilB homolog; May play a role in dynein arm assembly, hence essential for proper axoneme building for cilia motility; Belongs to the tilB family. | Radial spoke head protein 9 homolog; Probable component of the axonemal radial spoke head (By similarity). Radial spokes are regularly spaced along cilia, sperm and flagella axonemes. They consist of a thin stalk, which is attached to a subfiber of the outer doublet microtubule, and a bulbous head, which is attached to the stalk and appears to interact with the projections from the central pair of microtubules. | 0.708 |
Lrrc6 | Zmynd10 | ENSMUSP00000023006 | ENSMUSP00000010188 | Protein tilB homolog; May play a role in dynein arm assembly, hence essential for proper axoneme building for cilia motility; Belongs to the tilB family. | Zinc finger MYND domain-containing protein 10; Plays a role in axonemal structure organization and motility. Involved in axonemal pre-assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility. May act by indirectly regulating transcription of dynein proteins (By similarity); Belongs to the ZMYND10 family. | 0.936 |
Rsph3a | Ccdc39 | ENSMUSP00000095034 | ENSMUSP00000029222 | Radial spoke head protein 3 homolog A; Functions as a protein kinase A-anchoring protein that scaffolds the cAMP-dependent protein kinase holoenzyme. May serve as a point of convergence for MAPK and PKA signaling in cilia (By similarity). | Coiled-coil domain-containing protein 39; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with CCDC40 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella. Not required for outer dynein arm complexes assembly. | 0.447 |