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Jhy Jhy Zmynd10 Zmynd10 Rsph9 Rsph9 Lrrc6 Lrrc6 Ccdc39 Ccdc39 Ulk4 Ulk4 Sh2d5 Sh2d5 Rsph3a Rsph3a Uap1l1 Uap1l1 Bsx Bsx
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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[Homology]
Score
JhyJhy protein; Required for the normal development of cilia in brain ependymal cells lining the ventricular surfaces. (770 aa)    
Predicted Functional Partners:
Zmynd10
Zinc finger MYND domain-containing protein 10; Plays a role in axonemal structure organization and motility. Involved in axonemal pre-assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility. May act by indirectly regulating transcription of dynein proteins (By similarity); Belongs to the ZMYND10 family.
   
  
 0.659
Rsph9
Radial spoke head protein 9 homolog; Probable component of the axonemal radial spoke head (By similarity). Radial spokes are regularly spaced along cilia, sperm and flagella axonemes. They consist of a thin stalk, which is attached to a subfiber of the outer doublet microtubule, and a bulbous head, which is attached to the stalk and appears to interact with the projections from the central pair of microtubules.
   
  
 0.646
Lrrc6
Protein tilB homolog; May play a role in dynein arm assembly, hence essential for proper axoneme building for cilia motility; Belongs to the tilB family.
   
  
 0.610
Ccdc39
Coiled-coil domain-containing protein 39; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with CCDC40 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella. Not required for outer dynein arm complexes assembly.
   
  
 0.587
Ulk4
Serine/threonine-protein kinase ULK4; May be involved in the remodeling of cytoskeletal components, such as alpha-tubulin, and in this way regulates neurite branching and elongation, as well as cell motility; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.
   
  
 0.571
Sh2d5
SH2 domain-containing protein 5; May be involved in synaptic plasticity regulation through the control of Rac-GTP levels.
      
 0.478
Rsph3a
Radial spoke head protein 3 homolog A; Functions as a protein kinase A-anchoring protein that scaffolds the cAMP-dependent protein kinase holoenzyme. May serve as a point of convergence for MAPK and PKA signaling in cilia (By similarity).
   
  
 0.454
Uap1l1
UDP-N-acetylhexosamine pyrophosphorylase-like protein 1.
      
 0.436
Bsx
Brain-specific homeobox protein homolog; DNA binding protein that function as transcriptional activator. Is essential for normal postnatal growth and nursing. Is an essential factor for neuronal neuropeptide Y and agouti-related peptide function and locomotory behavior in the control of energy balance. Belongs to the distal-less homeobox family.
      
 0.410
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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