STRINGSTRING
Cmtm6 Cmtm6 Cklf Cklf Cmtm8 Cmtm8 Cd274 Cd274 Cmtm7 Cmtm7 Cmtm5 Cmtm5 Cmtm1 Cmtm1 Cmtm3 Cmtm3 Hip1r Hip1r Cd151 Cd151 4930402H24Rik 4930402H24Rik
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
Cmtm6CKLF-like MARVEL transmembrane domain-containing protein 6; Master regulator of recycling and plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. Associates with both constitutive and IFNG-induced PD-L1/CD274 at recycling endosomes, where it protects PD-L1/CD274 from being targeted for lysosomal degradation, likely by preventing its ubiquitination. May stabilize PD-L1/CD274 expression on antigen presenting cells and potentiates inhibitory signaling by PDCD1/CD279, its receptor on T-cells, ultimately trigge [...] (183 aa)    
Predicted Functional Partners:
Cklf
Chemokine-like factor; May play an important role in inflammation and regeneration of skeletal muscle.
      
 0.838
Cmtm8
CKLF-like MARVEL transmembrane domain-containing protein 8.
   
  
 0.809
Cd274
Programmed cell death 1 ligand 1; Plays a critical role in induction and maintenance of immune tolerance to self. As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response. Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10) ; Belongs to the immunoglobulin superfamily. BTN/MOG family.
   
 
 0.783
Cmtm7
CKLF-like MARVEL transmembrane domain-containing protein 7; Belongs to the chemokine-like factor family.
   
  
 0.763
Cmtm5
CKLF-like MARVEL transmembrane domain-containing protein 5; Belongs to the chemokine-like factor family.
      
 0.757
Cmtm1
CKLF-like MARVEL transmembrane domain-containing 1.
      
 0.676
Cmtm3
CKLF-like MARVEL transmembrane domain-containing protein 3.
   
  
 0.597
Hip1r
Huntingtin-interacting protein 1-related protein; Component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton. Binds 3- phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis.
   
  
 0.563
Cd151
CD151 antigen; Essential for the proper assembly of the glomerular and tubular basement membranes in kidney; Belongs to the tetraspanin (TM4SF) family.
   
  
 0.548
4930402H24Rik
Uncharacterized protein C20orf194 homolog; May act as an effector for ARL3.
      
 0.538
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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