STRINGSTRING
Kazn Kazn Ppl Ppl Evpl Evpl Ppfibp2 Ppfibp2 Ppfibp1 Ppfibp1 Rims2 Rims2 Sh3rf3 Sh3rf3 Git1 Git1 Arvcf Arvcf Git2 Git2 Eif4g1 Eif4g1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
Cooccurrence
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Experiments
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[Homology]
Score
KaznKazrin; Component of the cornified envelope of keratinocytes. May be involved in the interplay between adherens junctions and desmosomes. The function in the nucleus is not known. (414 aa)    
Predicted Functional Partners:
Ppl
Periplakin; Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. May act as a localization signal in PKB/AKT-mediated signaling.
    
 0.976
Evpl
Envoplakin; Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments.
   
 
 0.675
Ppfibp2
Liprin-beta-2; May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A (By similarity).
 
 
 
 0.607
Ppfibp1
Liprin-beta-1; May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A (By similarity). Belongs to the liprin family. Liprin-beta subfamily.
 
 
 
 0.588
Rims2
Regulating synaptic membrane exocytosis protein 2; Rab effector involved in exocytosis. May act as scaffold protein. Plays a role in dendrite formation by melanocytes (By similarity).
   
 
 0.563
Sh3rf3
E3 ubiquitin-protein ligase SH3RF3; Has E3 ubiquitin-protein ligase activity.
   
  
 0.531
Git1
ARF GTPase-activating protein GIT1; GTPase-activating protein for the ADP ribosylation factor family. May serve as a scaffold to bring together molecules to form signaling modules controlling vesicle trafficking, adhesion and cytoskeletal organization. Increases the speed of cell migration, as well as the size and rate of formation of protrusions, possibly by targeting PAK1 to adhesions and the leading edge of lamellipodia. Sequesters inactive non-tyrosine-phosphorylated paxillin in cytoplasmic complexes (By similarity). Involved in the regulation of cytokinesis; the function may invol [...]
   
 
 0.464
Arvcf
Armadillo repeat protein deleted in velo-cardio-facial syndrome homolog; Involved in protein-protein interactions at adherens junctions.
   
  
 0.459
Git2
ARF GTPase-activating protein GIT2; GTPase-activating protein for the ADP ribosylation factor family.
    
 
 0.450
Eif4g1
Eukaryotic translation initiation factor 4 gamma 1; Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome.
      
 0.444
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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