node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Apob | Hsd17b13 | ENSMUSP00000036044 | ENSMUSP00000046772 | Apolipoprotein B-100; Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B- 100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor. | 17-beta-hydroxysteroid dehydrogenase 13. | 0.460 |
Apob | Pnpla3 | ENSMUSP00000036044 | ENSMUSP00000043826 | Apolipoprotein B-100; Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B- 100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor. | 1-acylglycerol-3-phosphate O-acyltransferase Pnpla3; Specifically catalyzes coenzyme A (CoA)-dependent acylation of 1-acyl-sn-glycerol 3-phosphate (2-lysophosphatidic acid/LPA) to generate phosphatidic acid (PA), an important metabolic intermediate and precursor for both triglycerides and glycerophospholipids. Does not esterify other lysophospholipids. Acyl donors are long chain (at least C16) fatty acyl-CoAs: arachidonoyl-CoA, linoleoyl-CoA, oleoyl-CoA and at a lesser extent palmitoyl-CoA. Additionally possesses low triacylglycerol lipase and CoA-independent acylglycerol transacylase [...] | 0.562 |
Apob | Tm6sf2 | ENSMUSP00000036044 | ENSMUSP00000105788 | Apolipoprotein B-100; Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B- 100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor. | Transmembrane 6 superfamily member 2; Regulator of liver fat metabolism influencing triglyceride secretion and hepatic lipid droplet content. May function as sterol isomerase; Belongs to the TM6SF family. | 0.689 |
Hsd17b13 | Apob | ENSMUSP00000046772 | ENSMUSP00000036044 | 17-beta-hydroxysteroid dehydrogenase 13. | Apolipoprotein B-100; Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B- 100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor. | 0.460 |
Hsd17b13 | Ltc4s | ENSMUSP00000046772 | ENSMUSP00000099833 | 17-beta-hydroxysteroid dehydrogenase 13. | Leukotriene C4 synthase; Catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4. | 0.520 |
Hsd17b13 | Lyplal1 | ENSMUSP00000046772 | ENSMUSP00000048229 | 17-beta-hydroxysteroid dehydrogenase 13. | Lysophospholipase-like protein 1; Has depalmitoylating activity toward KCNMA1. Does not exhibit phospholipase nor triacylglycerol lipase activity, able to hydrolyze only short chain substrates due to its shallow active site (By similarity). | 0.501 |
Hsd17b13 | Marc1 | ENSMUSP00000046772 | ENSMUSP00000035804 | 17-beta-hydroxysteroid dehydrogenase 13. | Mitochondrial amidoxime-reducing component 1; Catalyzes the reduction of N-oxygenated molecules, acting as a counterpart of cytochrome P450 and flavin-containing monooxygenases in metabolic cycles. As a component of prodrug-converting system, reduces a multitude of N-hydroxylated prodrugs particularly amidoximes, leading to increased drug bioavailability. May be involved in mitochondrial N(omega)-hydroxy-L-arginine (NOHA) reduction, regulating endogenous nitric oxide levels and biosynthesis. Postulated to cleave the N-OH bond of N-hydroxylated substrates in concert with electron transf [...] | 0.564 |
Hsd17b13 | Mboat7 | ENSMUSP00000046772 | ENSMUSP00000037107 | 17-beta-hydroxysteroid dehydrogenase 13. | Lysophospholipid acyltransferase 7; Acyltransferase which contributes to the regulation of free arachidonic acid (AA) in the cell through the remodeling of phospholipids. Mediates the conversion of lysophosphatidylinositol (1- acylglycerophosphatidylinositol or LPI) into phosphatidylinositol (1,2- diacyl-sn-glycero-3-phosphoinositol or PI) (LPIAT activity). Prefers arachidonoyl-CoA as the acyl donor. Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle (By similarity). Required for cortical laminat [...] | 0.789 |
Hsd17b13 | Pecr | ENSMUSP00000046772 | ENSMUSP00000027381 | 17-beta-hydroxysteroid dehydrogenase 13. | Peroxisomal trans-2-enoyl-CoA reductase; Participates in chain elongation of fatty acids. Has no 2,4- dienoyl-CoA reductase activity (By similarity); Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.479 |
Hsd17b13 | Pnpla3 | ENSMUSP00000046772 | ENSMUSP00000043826 | 17-beta-hydroxysteroid dehydrogenase 13. | 1-acylglycerol-3-phosphate O-acyltransferase Pnpla3; Specifically catalyzes coenzyme A (CoA)-dependent acylation of 1-acyl-sn-glycerol 3-phosphate (2-lysophosphatidic acid/LPA) to generate phosphatidic acid (PA), an important metabolic intermediate and precursor for both triglycerides and glycerophospholipids. Does not esterify other lysophospholipids. Acyl donors are long chain (at least C16) fatty acyl-CoAs: arachidonoyl-CoA, linoleoyl-CoA, oleoyl-CoA and at a lesser extent palmitoyl-CoA. Additionally possesses low triacylglycerol lipase and CoA-independent acylglycerol transacylase [...] | 0.808 |
Hsd17b13 | Ripor3 | ENSMUSP00000046772 | ENSMUSP00000096672 | 17-beta-hydroxysteroid dehydrogenase 13. | RIPOR family member 3; Belongs to the RIPOR family. | 0.591 |
Hsd17b13 | Them7 | ENSMUSP00000046772 | ENSMUSP00000063340 | 17-beta-hydroxysteroid dehydrogenase 13. | Novel Thioesterase superfamily domain and Saposin A-type domain containing protein (0610012H03Rik). | 0.490 |
Hsd17b13 | Tm6sf2 | ENSMUSP00000046772 | ENSMUSP00000105788 | 17-beta-hydroxysteroid dehydrogenase 13. | Transmembrane 6 superfamily member 2; Regulator of liver fat metabolism influencing triglyceride secretion and hepatic lipid droplet content. May function as sterol isomerase; Belongs to the TM6SF family. | 0.826 |
Ltc4s | Hsd17b13 | ENSMUSP00000099833 | ENSMUSP00000046772 | Leukotriene C4 synthase; Catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4. | 17-beta-hydroxysteroid dehydrogenase 13. | 0.520 |
Ltc4s | Ripor3 | ENSMUSP00000099833 | ENSMUSP00000096672 | Leukotriene C4 synthase; Catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4. | RIPOR family member 3; Belongs to the RIPOR family. | 0.550 |
Lyplal1 | Hsd17b13 | ENSMUSP00000048229 | ENSMUSP00000046772 | Lysophospholipase-like protein 1; Has depalmitoylating activity toward KCNMA1. Does not exhibit phospholipase nor triacylglycerol lipase activity, able to hydrolyze only short chain substrates due to its shallow active site (By similarity). | 17-beta-hydroxysteroid dehydrogenase 13. | 0.501 |
Lyplal1 | Mboat7 | ENSMUSP00000048229 | ENSMUSP00000037107 | Lysophospholipase-like protein 1; Has depalmitoylating activity toward KCNMA1. Does not exhibit phospholipase nor triacylglycerol lipase activity, able to hydrolyze only short chain substrates due to its shallow active site (By similarity). | Lysophospholipid acyltransferase 7; Acyltransferase which contributes to the regulation of free arachidonic acid (AA) in the cell through the remodeling of phospholipids. Mediates the conversion of lysophosphatidylinositol (1- acylglycerophosphatidylinositol or LPI) into phosphatidylinositol (1,2- diacyl-sn-glycero-3-phosphoinositol or PI) (LPIAT activity). Prefers arachidonoyl-CoA as the acyl donor. Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle (By similarity). Required for cortical laminat [...] | 0.604 |
Lyplal1 | Pnpla3 | ENSMUSP00000048229 | ENSMUSP00000043826 | Lysophospholipase-like protein 1; Has depalmitoylating activity toward KCNMA1. Does not exhibit phospholipase nor triacylglycerol lipase activity, able to hydrolyze only short chain substrates due to its shallow active site (By similarity). | 1-acylglycerol-3-phosphate O-acyltransferase Pnpla3; Specifically catalyzes coenzyme A (CoA)-dependent acylation of 1-acyl-sn-glycerol 3-phosphate (2-lysophosphatidic acid/LPA) to generate phosphatidic acid (PA), an important metabolic intermediate and precursor for both triglycerides and glycerophospholipids. Does not esterify other lysophospholipids. Acyl donors are long chain (at least C16) fatty acyl-CoAs: arachidonoyl-CoA, linoleoyl-CoA, oleoyl-CoA and at a lesser extent palmitoyl-CoA. Additionally possesses low triacylglycerol lipase and CoA-independent acylglycerol transacylase [...] | 0.717 |
Lyplal1 | Tm6sf2 | ENSMUSP00000048229 | ENSMUSP00000105788 | Lysophospholipase-like protein 1; Has depalmitoylating activity toward KCNMA1. Does not exhibit phospholipase nor triacylglycerol lipase activity, able to hydrolyze only short chain substrates due to its shallow active site (By similarity). | Transmembrane 6 superfamily member 2; Regulator of liver fat metabolism influencing triglyceride secretion and hepatic lipid droplet content. May function as sterol isomerase; Belongs to the TM6SF family. | 0.697 |
Marc1 | Hsd17b13 | ENSMUSP00000035804 | ENSMUSP00000046772 | Mitochondrial amidoxime-reducing component 1; Catalyzes the reduction of N-oxygenated molecules, acting as a counterpart of cytochrome P450 and flavin-containing monooxygenases in metabolic cycles. As a component of prodrug-converting system, reduces a multitude of N-hydroxylated prodrugs particularly amidoximes, leading to increased drug bioavailability. May be involved in mitochondrial N(omega)-hydroxy-L-arginine (NOHA) reduction, regulating endogenous nitric oxide levels and biosynthesis. Postulated to cleave the N-OH bond of N-hydroxylated substrates in concert with electron transf [...] | 17-beta-hydroxysteroid dehydrogenase 13. | 0.564 |