node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Clec14a | Clec1a | ENSMUSP00000054451 | ENSMUSP00000047065 | C-type lectin domain family 14 member A. | C-type lectin domain family 1 member A. | 0.701 |
Clec1a | Clec14a | ENSMUSP00000047065 | ENSMUSP00000054451 | C-type lectin domain family 1 member A. | C-type lectin domain family 14 member A. | 0.701 |
Clec1a | Clec2m | ENSMUSP00000047065 | ENSMUSP00000062024 | C-type lectin domain family 1 member A. | C-type lectin domain family 2, member m. | 0.538 |
Clec1a | Clec4a3 | ENSMUSP00000047065 | ENSMUSP00000085816 | C-type lectin domain family 1 member A. | C-type lectin domain family 4, member a3. | 0.469 |
Clec1a | Clec4d | ENSMUSP00000047065 | ENSMUSP00000032240 | C-type lectin domain family 1 member A. | C-type lectin domain family 4 member D; A calcium-dependent lectin involved in innate recognition of pathogen-associated molecular patterns (PAMPs). Interacts with signaling adapter Fc receptor gamma chain/FCER1G, likely via CLEC4E, to form a functional complex in antigen presenting cells. Binding of mycobacterial trehalose 6,6'-dimycolate (TDM) to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shapin [...] | 0.739 |
Clec1a | Clec4e | ENSMUSP00000047065 | ENSMUSP00000032239 | C-type lectin domain family 1 member A. | C-type lectin domain family 4 member E; A calcium-dependent lectin that acts as a pattern recognition receptor of the innate immune system. Recognizes damage-associated molecular patterns (DAMPs) of abnormal self and pathogen-associated molecular patterns (PAMPs) of bacteria and fungi. The PAMPs notably include mycobacterial trehalose 6,6'-dimycolate (TDM), a cell wall glycolipid with potent adjuvant immunomodulatory functions. Interacts with signaling adapter Fc receptor gamma chain/FCER1G to form a functional complex in myeloid cells. Binding of mycobacterial trehalose 6,6'-dimycolat [...] | 0.757 |
Clec1a | Clec4g | ENSMUSP00000047065 | ENSMUSP00000059574 | C-type lectin domain family 1 member A. | C-type lectin domain family 4 member G; Binds mannose, N-acetylglucosamine (GlcNAc) and fucose, but not galactose, in a Ca(2+)-dependent manner. | 0.556 |
Clec1a | Clec4n | ENSMUSP00000047065 | ENSMUSP00000024118 | C-type lectin domain family 1 member A. | C-type lectin domain family 6 member A; Binds high-mannose carbohydrates in a Ca(2+)-dependent manner. Functional receptor for alpha-mannans on C.albicans hypheas. Plays an important role in the host defense against C.albicans infection by inducing TH17 cell differentiation. Recognizes also, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production. Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptive immune responses. Transduces signals through an Fc receptor gamma chain /FCER1G and Syk- CARD9-NF [...] | 0.439 |
Clec1a | Dhrs13 | ENSMUSP00000047065 | ENSMUSP00000021187 | C-type lectin domain family 1 member A. | Dehydrogenase/reductase SDR family member 13; Putative oxidoreductase. | 0.529 |
Clec1a | Glipr1l2 | ENSMUSP00000047065 | ENSMUSP00000020434 | C-type lectin domain family 1 member A. | GLIPR1-like protein 2; Belongs to the CRISP family. | 0.451 |
Clec1a | Pdpn | ENSMUSP00000047065 | ENSMUSP00000030317 | C-type lectin domain family 1 member A. | Podoplanin; Mediates effects on cell migration and adhesion through its different partners. During development plays a role in blood and lymphatic vessels separation by binding CLEC1B, triggering CLEC1B activation in platelets and leading to platelet activation and/or aggregation. Interaction with CD9, on the contrary, attenuates platelet aggregation and pulmonary metastasis induced by PDPN. Mediates effects on cell migration and adhesion through its different partners. Through MSN or EZR interaction promotes epithelial-mesenchymal transition (EMT) leading to ERZ phosphorylation and tr [...] | 0.629 |
Clec2m | Clec1a | ENSMUSP00000062024 | ENSMUSP00000047065 | C-type lectin domain family 2, member m. | C-type lectin domain family 1 member A. | 0.538 |
Clec4a3 | Clec1a | ENSMUSP00000085816 | ENSMUSP00000047065 | C-type lectin domain family 4, member a3. | C-type lectin domain family 1 member A. | 0.469 |
Clec4a3 | Clec4d | ENSMUSP00000085816 | ENSMUSP00000032240 | C-type lectin domain family 4, member a3. | C-type lectin domain family 4 member D; A calcium-dependent lectin involved in innate recognition of pathogen-associated molecular patterns (PAMPs). Interacts with signaling adapter Fc receptor gamma chain/FCER1G, likely via CLEC4E, to form a functional complex in antigen presenting cells. Binding of mycobacterial trehalose 6,6'-dimycolate (TDM) to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shapin [...] | 0.526 |
Clec4a3 | Clec4e | ENSMUSP00000085816 | ENSMUSP00000032239 | C-type lectin domain family 4, member a3. | C-type lectin domain family 4 member E; A calcium-dependent lectin that acts as a pattern recognition receptor of the innate immune system. Recognizes damage-associated molecular patterns (DAMPs) of abnormal self and pathogen-associated molecular patterns (PAMPs) of bacteria and fungi. The PAMPs notably include mycobacterial trehalose 6,6'-dimycolate (TDM), a cell wall glycolipid with potent adjuvant immunomodulatory functions. Interacts with signaling adapter Fc receptor gamma chain/FCER1G to form a functional complex in myeloid cells. Binding of mycobacterial trehalose 6,6'-dimycolat [...] | 0.508 |
Clec4d | Clec1a | ENSMUSP00000032240 | ENSMUSP00000047065 | C-type lectin domain family 4 member D; A calcium-dependent lectin involved in innate recognition of pathogen-associated molecular patterns (PAMPs). Interacts with signaling adapter Fc receptor gamma chain/FCER1G, likely via CLEC4E, to form a functional complex in antigen presenting cells. Binding of mycobacterial trehalose 6,6'-dimycolate (TDM) to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shapin [...] | C-type lectin domain family 1 member A. | 0.739 |
Clec4d | Clec4a3 | ENSMUSP00000032240 | ENSMUSP00000085816 | C-type lectin domain family 4 member D; A calcium-dependent lectin involved in innate recognition of pathogen-associated molecular patterns (PAMPs). Interacts with signaling adapter Fc receptor gamma chain/FCER1G, likely via CLEC4E, to form a functional complex in antigen presenting cells. Binding of mycobacterial trehalose 6,6'-dimycolate (TDM) to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shapin [...] | C-type lectin domain family 4, member a3. | 0.526 |
Clec4d | Clec4e | ENSMUSP00000032240 | ENSMUSP00000032239 | C-type lectin domain family 4 member D; A calcium-dependent lectin involved in innate recognition of pathogen-associated molecular patterns (PAMPs). Interacts with signaling adapter Fc receptor gamma chain/FCER1G, likely via CLEC4E, to form a functional complex in antigen presenting cells. Binding of mycobacterial trehalose 6,6'-dimycolate (TDM) to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shapin [...] | C-type lectin domain family 4 member E; A calcium-dependent lectin that acts as a pattern recognition receptor of the innate immune system. Recognizes damage-associated molecular patterns (DAMPs) of abnormal self and pathogen-associated molecular patterns (PAMPs) of bacteria and fungi. The PAMPs notably include mycobacterial trehalose 6,6'-dimycolate (TDM), a cell wall glycolipid with potent adjuvant immunomodulatory functions. Interacts with signaling adapter Fc receptor gamma chain/FCER1G to form a functional complex in myeloid cells. Binding of mycobacterial trehalose 6,6'-dimycolat [...] | 0.989 |
Clec4d | Clec4n | ENSMUSP00000032240 | ENSMUSP00000024118 | C-type lectin domain family 4 member D; A calcium-dependent lectin involved in innate recognition of pathogen-associated molecular patterns (PAMPs). Interacts with signaling adapter Fc receptor gamma chain/FCER1G, likely via CLEC4E, to form a functional complex in antigen presenting cells. Binding of mycobacterial trehalose 6,6'-dimycolate (TDM) to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shapin [...] | C-type lectin domain family 6 member A; Binds high-mannose carbohydrates in a Ca(2+)-dependent manner. Functional receptor for alpha-mannans on C.albicans hypheas. Plays an important role in the host defense against C.albicans infection by inducing TH17 cell differentiation. Recognizes also, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production. Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptive immune responses. Transduces signals through an Fc receptor gamma chain /FCER1G and Syk- CARD9-NF [...] | 0.806 |
Clec4e | Clec1a | ENSMUSP00000032239 | ENSMUSP00000047065 | C-type lectin domain family 4 member E; A calcium-dependent lectin that acts as a pattern recognition receptor of the innate immune system. Recognizes damage-associated molecular patterns (DAMPs) of abnormal self and pathogen-associated molecular patterns (PAMPs) of bacteria and fungi. The PAMPs notably include mycobacterial trehalose 6,6'-dimycolate (TDM), a cell wall glycolipid with potent adjuvant immunomodulatory functions. Interacts with signaling adapter Fc receptor gamma chain/FCER1G to form a functional complex in myeloid cells. Binding of mycobacterial trehalose 6,6'-dimycolat [...] | C-type lectin domain family 1 member A. | 0.757 |