node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Acaa1a | Acaa1b | ENSMUSP00000042351 | ENSMUSP00000010795 | 3-ketoacyl-CoA thiolase A, peroxisomal. | 3-ketoacyl-CoA thiolase B, peroxisomal. | 0.919 |
Acaa1a | Acadl | ENSMUSP00000042351 | ENSMUSP00000027153 | 3-ketoacyl-CoA thiolase A, peroxisomal. | Long-chain specific acyl-CoA dehydrogenase, mitochondrial; Long-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA (By similarity). Among the different mitochondrial acyl-CoA dehydrogenas [...] | 0.975 |
Acaa1a | Acox2 | ENSMUSP00000042351 | ENSMUSP00000126464 | 3-ketoacyl-CoA thiolase A, peroxisomal. | Peroxisomal acyl-coenzyme A oxidase 2; Oxidizes the CoA esters of the bile acid intermediates di- and tri-hydroxycoprostanic acids (By similarity). Capable of oxidizing short as well as long chain 2-methyl branched fatty acids (By similarity). | 0.853 |
Acaa1a | Acsf2 | ENSMUSP00000042351 | ENSMUSP00000099453 | 3-ketoacyl-CoA thiolase A, peroxisomal. | Medium-chain acyl-CoA ligase ACSF2, mitochondrial; Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA. Has some preference toward medium-chain substrates. Plays a role in adipocyte differentiation; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.458 |
Acaa1a | Echdc2 | ENSMUSP00000042351 | ENSMUSP00000051268 | 3-ketoacyl-CoA thiolase A, peroxisomal. | Enoyl-CoA hydratase domain-containing protein 2, mitochondrial; Belongs to the enoyl-CoA hydratase/isomerase family. | 0.653 |
Acaa1a | Hadh | ENSMUSP00000042351 | ENSMUSP00000029610 | 3-ketoacyl-CoA thiolase A, peroxisomal. | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial; Plays an essential role in the mitochondrial beta-oxidation of short chain fatty acids. Exerts it highest activity toward 3- hydroxybutyryl-CoA; Belongs to the 3-hydroxyacyl-CoA dehydrogenase family. | 0.987 |
Acaa1a | Hadhb | ENSMUSP00000042351 | ENSMUSP00000110434 | 3-ketoacyl-CoA thiolase A, peroxisomal. | Trifunctional enzyme subunit beta, mitochondrial; Mitochondrial trifunctional enzyme catalyzes the last three of the four reactions of the mitochondrial beta-oxidation pathway. The mitochondrial beta-oxidation pathway is the major energy-producing process in tissues and is performed through four consecutive reactions breaking down fatty acids into acetyl-CoA. Among the enzymes involved in this pathway, the trifunctional enzyme exhibits specificity for long-chain fatty acids. Mitochondrial trifunctional enzyme is a heterotetrameric complex composed of two proteins, the trifunctional enz [...] | 0.527 |
Acaa1a | Ivd | ENSMUSP00000042351 | ENSMUSP00000028807 | 3-ketoacyl-CoA thiolase A, peroxisomal. | Isovaleryl-CoA dehydrogenase, mitochondrial; Belongs to the acyl-CoA dehydrogenase family. | 0.608 |
Acaa1b | Acaa1a | ENSMUSP00000010795 | ENSMUSP00000042351 | 3-ketoacyl-CoA thiolase B, peroxisomal. | 3-ketoacyl-CoA thiolase A, peroxisomal. | 0.919 |
Acaa1b | Acadl | ENSMUSP00000010795 | ENSMUSP00000027153 | 3-ketoacyl-CoA thiolase B, peroxisomal. | Long-chain specific acyl-CoA dehydrogenase, mitochondrial; Long-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA (By similarity). Among the different mitochondrial acyl-CoA dehydrogenas [...] | 0.975 |
Acaa1b | Acox2 | ENSMUSP00000010795 | ENSMUSP00000126464 | 3-ketoacyl-CoA thiolase B, peroxisomal. | Peroxisomal acyl-coenzyme A oxidase 2; Oxidizes the CoA esters of the bile acid intermediates di- and tri-hydroxycoprostanic acids (By similarity). Capable of oxidizing short as well as long chain 2-methyl branched fatty acids (By similarity). | 0.833 |
Acaa1b | Acsf2 | ENSMUSP00000010795 | ENSMUSP00000099453 | 3-ketoacyl-CoA thiolase B, peroxisomal. | Medium-chain acyl-CoA ligase ACSF2, mitochondrial; Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA. Has some preference toward medium-chain substrates. Plays a role in adipocyte differentiation; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.534 |
Acaa1b | Echdc2 | ENSMUSP00000010795 | ENSMUSP00000051268 | 3-ketoacyl-CoA thiolase B, peroxisomal. | Enoyl-CoA hydratase domain-containing protein 2, mitochondrial; Belongs to the enoyl-CoA hydratase/isomerase family. | 0.661 |
Acaa1b | Hadh | ENSMUSP00000010795 | ENSMUSP00000029610 | 3-ketoacyl-CoA thiolase B, peroxisomal. | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial; Plays an essential role in the mitochondrial beta-oxidation of short chain fatty acids. Exerts it highest activity toward 3- hydroxybutyryl-CoA; Belongs to the 3-hydroxyacyl-CoA dehydrogenase family. | 0.986 |
Acaa1b | Hadhb | ENSMUSP00000010795 | ENSMUSP00000110434 | 3-ketoacyl-CoA thiolase B, peroxisomal. | Trifunctional enzyme subunit beta, mitochondrial; Mitochondrial trifunctional enzyme catalyzes the last three of the four reactions of the mitochondrial beta-oxidation pathway. The mitochondrial beta-oxidation pathway is the major energy-producing process in tissues and is performed through four consecutive reactions breaking down fatty acids into acetyl-CoA. Among the enzymes involved in this pathway, the trifunctional enzyme exhibits specificity for long-chain fatty acids. Mitochondrial trifunctional enzyme is a heterotetrameric complex composed of two proteins, the trifunctional enz [...] | 0.512 |
Acaa1b | Ivd | ENSMUSP00000010795 | ENSMUSP00000028807 | 3-ketoacyl-CoA thiolase B, peroxisomal. | Isovaleryl-CoA dehydrogenase, mitochondrial; Belongs to the acyl-CoA dehydrogenase family. | 0.582 |
Acaa2 | Acadl | ENSMUSP00000037348 | ENSMUSP00000027153 | 3-ketoacyl-CoA thiolase, mitochondrial; In the production of energy from fats, this is one of the enzymes that catalyzes the last step of the mitochondrial beta- oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA. Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain unbranched 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms. Also catalyzes the condensation of two acetyl-CoA molecules into acetoacetyl-CoA and could be involved in the production of ketone bodies. Also displays hydrolase activit [...] | Long-chain specific acyl-CoA dehydrogenase, mitochondrial; Long-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA (By similarity). Among the different mitochondrial acyl-CoA dehydrogenas [...] | 0.986 |
Acaa2 | Acox2 | ENSMUSP00000037348 | ENSMUSP00000126464 | 3-ketoacyl-CoA thiolase, mitochondrial; In the production of energy from fats, this is one of the enzymes that catalyzes the last step of the mitochondrial beta- oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA. Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain unbranched 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms. Also catalyzes the condensation of two acetyl-CoA molecules into acetoacetyl-CoA and could be involved in the production of ketone bodies. Also displays hydrolase activit [...] | Peroxisomal acyl-coenzyme A oxidase 2; Oxidizes the CoA esters of the bile acid intermediates di- and tri-hydroxycoprostanic acids (By similarity). Capable of oxidizing short as well as long chain 2-methyl branched fatty acids (By similarity). | 0.554 |
Acaa2 | Acsf2 | ENSMUSP00000037348 | ENSMUSP00000099453 | 3-ketoacyl-CoA thiolase, mitochondrial; In the production of energy from fats, this is one of the enzymes that catalyzes the last step of the mitochondrial beta- oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA. Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain unbranched 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms. Also catalyzes the condensation of two acetyl-CoA molecules into acetoacetyl-CoA and could be involved in the production of ketone bodies. Also displays hydrolase activit [...] | Medium-chain acyl-CoA ligase ACSF2, mitochondrial; Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA. Has some preference toward medium-chain substrates. Plays a role in adipocyte differentiation; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.543 |
Acaa2 | Echdc2 | ENSMUSP00000037348 | ENSMUSP00000051268 | 3-ketoacyl-CoA thiolase, mitochondrial; In the production of energy from fats, this is one of the enzymes that catalyzes the last step of the mitochondrial beta- oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA. Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain unbranched 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms. Also catalyzes the condensation of two acetyl-CoA molecules into acetoacetyl-CoA and could be involved in the production of ketone bodies. Also displays hydrolase activit [...] | Enoyl-CoA hydratase domain-containing protein 2, mitochondrial; Belongs to the enoyl-CoA hydratase/isomerase family. | 0.564 |