node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Mex3c | Shisa2 | ENSMUSP00000089463 | ENSMUSP00000059391 | RNA-binding E3 ubiquitin-protein ligase MEX3C; RNA-binding protein. May be involved in post-transcriptional regulatory mechanisms, modulating levels of some mRNAs by promoting their degradation in a way involving ubiquitin ligase activity. May act as suppressor of replication stress and chromosome missegregation. | Protein shisa-2 homolog; Plays an essential role in the maturation of presomitic mesoderm cells by individual attenuation of both FGF and WNT signaling. Belongs to the shisa family. | 0.446 |
Mex3c | Slitrk6 | ENSMUSP00000089463 | ENSMUSP00000077492 | RNA-binding E3 ubiquitin-protein ligase MEX3C; RNA-binding protein. May be involved in post-transcriptional regulatory mechanisms, modulating levels of some mRNAs by promoting their degradation in a way involving ubiquitin ligase activity. May act as suppressor of replication stress and chromosome missegregation. | SLIT and NTRK-like protein 6; Regulator of neurite outgrowth required for normal hearing and vision. | 0.415 |
Mex3c | Zfp646 | ENSMUSP00000089463 | ENSMUSP00000052641 | RNA-binding E3 ubiquitin-protein ligase MEX3C; RNA-binding protein. May be involved in post-transcriptional regulatory mechanisms, modulating levels of some mRNAs by promoting their degradation in a way involving ubiquitin ligase activity. May act as suppressor of replication stress and chromosome missegregation. | Zinc finger protein 646; May be involved in transcriptional regulation. | 0.466 |
Pald1 | Parp2 | ENSMUSP00000020289 | ENSMUSP00000048877 | Paladin. | Poly [ADP-ribose] polymerase 2; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. Mainly mediates glutamate and aspartate ADP- ribosylation of target proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of glutamate and aspartate residues and further ADP-ribosyl groups are transferred to the 2'- position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units (By similarity). ADP- ribosylation follows DNA damage and appears as an obligatory ste [...] | 0.482 |
Pald1 | Zfp646 | ENSMUSP00000020289 | ENSMUSP00000052641 | Paladin. | Zinc finger protein 646; May be involved in transcriptional regulation. | 0.528 |
Parp2 | Pald1 | ENSMUSP00000048877 | ENSMUSP00000020289 | Poly [ADP-ribose] polymerase 2; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. Mainly mediates glutamate and aspartate ADP- ribosylation of target proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of glutamate and aspartate residues and further ADP-ribosyl groups are transferred to the 2'- position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units (By similarity). ADP- ribosylation follows DNA damage and appears as an obligatory ste [...] | Paladin. | 0.482 |
Parp2 | Zfp646 | ENSMUSP00000048877 | ENSMUSP00000052641 | Poly [ADP-ribose] polymerase 2; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. Mainly mediates glutamate and aspartate ADP- ribosylation of target proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of glutamate and aspartate residues and further ADP-ribosyl groups are transferred to the 2'- position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units (By similarity). ADP- ribosylation follows DNA damage and appears as an obligatory ste [...] | Zinc finger protein 646; May be involved in transcriptional regulation. | 0.465 |
Pds5a | Zfp646 | ENSMUSP00000144171 | ENSMUSP00000052641 | Sister chromatid cohesion protein PDS5 homolog A; Probable regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair (By similarity). | Zinc finger protein 646; May be involved in transcriptional regulation. | 0.473 |
Prss53 | Zfp646 | ENSMUSP00000112972 | ENSMUSP00000052641 | Serine protease 53; In vitro can degrade the fibrinogen alpha chain of as well as pro-urokinase-type plasminogen activator; Belongs to the peptidase S1 family. | Zinc finger protein 646; May be involved in transcriptional regulation. | 0.535 |
Rhno1 | Zfp646 | ENSMUSP00000107779 | ENSMUSP00000052641 | RAD9, HUS1, RAD1-interacting nuclear orphan protein 1; Plays a role in DNA damage response (DDR) signaling upon genotoxic stresses such as ionizing radiation (IR) during the S phase. Recruited to sites of DNA damage through interaction with the 9-1-1 cell-cycle checkpoint response complex and TOPBP1 in a ATR-dependent manner. Required for the progression of the G1 to S phase transition. Plays a role in the stimulation of CHEK1 phosphorylation (By similarity). | Zinc finger protein 646; May be involved in transcriptional regulation. | 0.479 |
Rnf40 | Zfp646 | ENSMUSP00000146310 | ENSMUSP00000052641 | E3 ubiquitin-protein ligase BRE1B; Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradic [...] | Zinc finger protein 646; May be involved in transcriptional regulation. | 0.581 |
Shisa2 | Mex3c | ENSMUSP00000059391 | ENSMUSP00000089463 | Protein shisa-2 homolog; Plays an essential role in the maturation of presomitic mesoderm cells by individual attenuation of both FGF and WNT signaling. Belongs to the shisa family. | RNA-binding E3 ubiquitin-protein ligase MEX3C; RNA-binding protein. May be involved in post-transcriptional regulatory mechanisms, modulating levels of some mRNAs by promoting their degradation in a way involving ubiquitin ligase activity. May act as suppressor of replication stress and chromosome missegregation. | 0.446 |
Shisa2 | Slitrk6 | ENSMUSP00000059391 | ENSMUSP00000077492 | Protein shisa-2 homolog; Plays an essential role in the maturation of presomitic mesoderm cells by individual attenuation of both FGF and WNT signaling. Belongs to the shisa family. | SLIT and NTRK-like protein 6; Regulator of neurite outgrowth required for normal hearing and vision. | 0.441 |
Shisa2 | Zfp646 | ENSMUSP00000059391 | ENSMUSP00000052641 | Protein shisa-2 homolog; Plays an essential role in the maturation of presomitic mesoderm cells by individual attenuation of both FGF and WNT signaling. Belongs to the shisa family. | Zinc finger protein 646; May be involved in transcriptional regulation. | 0.472 |
Slitrk6 | Mex3c | ENSMUSP00000077492 | ENSMUSP00000089463 | SLIT and NTRK-like protein 6; Regulator of neurite outgrowth required for normal hearing and vision. | RNA-binding E3 ubiquitin-protein ligase MEX3C; RNA-binding protein. May be involved in post-transcriptional regulatory mechanisms, modulating levels of some mRNAs by promoting their degradation in a way involving ubiquitin ligase activity. May act as suppressor of replication stress and chromosome missegregation. | 0.415 |
Slitrk6 | Shisa2 | ENSMUSP00000077492 | ENSMUSP00000059391 | SLIT and NTRK-like protein 6; Regulator of neurite outgrowth required for normal hearing and vision. | Protein shisa-2 homolog; Plays an essential role in the maturation of presomitic mesoderm cells by individual attenuation of both FGF and WNT signaling. Belongs to the shisa family. | 0.441 |
Slitrk6 | Zfp646 | ENSMUSP00000077492 | ENSMUSP00000052641 | SLIT and NTRK-like protein 6; Regulator of neurite outgrowth required for normal hearing and vision. | Zinc finger protein 646; May be involved in transcriptional regulation. | 0.471 |
Zc3h4 | Zfp646 | ENSMUSP00000096386 | ENSMUSP00000052641 | Zinc finger CCCH domain-containing protein 4. | Zinc finger protein 646; May be involved in transcriptional regulation. | 0.461 |
Zfp646 | Mex3c | ENSMUSP00000052641 | ENSMUSP00000089463 | Zinc finger protein 646; May be involved in transcriptional regulation. | RNA-binding E3 ubiquitin-protein ligase MEX3C; RNA-binding protein. May be involved in post-transcriptional regulatory mechanisms, modulating levels of some mRNAs by promoting their degradation in a way involving ubiquitin ligase activity. May act as suppressor of replication stress and chromosome missegregation. | 0.466 |
Zfp646 | Pald1 | ENSMUSP00000052641 | ENSMUSP00000020289 | Zinc finger protein 646; May be involved in transcriptional regulation. | Paladin. | 0.528 |