STRINGSTRING
Pcdhb16 Pcdhb16 Pcdhb17 Pcdhb17 Pcdhb20 Pcdhb20 Pcdhb21 Pcdhb21 Pcdhb18 Pcdhb18 Pcdhb19 Pcdhb19 Pcdhb15 Pcdhb15 Pcdhb7 Pcdhb7 Cldn11 Cldn11 Pcdh15 Pcdh15 Rreb1 Rreb1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Pcdhb16Protocadherin beta 16. (802 aa)    
Predicted Functional Partners:
Pcdhb17
Protocadherin beta 17.
  
  
0.858
Pcdhb20
Protocadherin beta 20.
  
  
0.847
Pcdhb21
Protocadherin beta 21.
  
  
0.844
Pcdhb18
Protocadherin beta-18; Potential calcium-dependent cell-adhesion protein.
  
  
0.827
Pcdhb19
Protocadherin beta 19.
  
  
0.826
Pcdhb15
Protocadherin beta 15.
  
  
0.586
Pcdhb7
Protocadherin beta 7.
  
  
0.533
Cldn11
Claudin-11; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.
      
 0.451
Pcdh15
Protocadherin-15; Calcium-dependent cell-adhesion protein. Required for inner ear neuroepithelial cell elaboration and cochlear function. Probably involved in the maintenance of normal retinal function.
   
 
0.446
Rreb1
Ras-responsive element-binding protein 1; Transcription factor that binds specifically to the RAS- responsive elements (RRE) of gene promoters. May be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression. Represses the angiotensinogen gene. Negatively regulates the transcriptional activity of AR. Potentiates the transcriptional activity of NEUROD1 (By similarity). Binds specifically to the allelic variant of the CDKN2A promoter present in Balb/c mice, which leads to a down-regulation of CDKN2A expression in this strain, and, as a consequence, to an eleva [...]
      
 0.420
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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