STRINGSTRING
Ubald2 Ubald2 Ccdc150 Ccdc150 Edem2 Edem2 Akirin2 Akirin2 Ccdc77 Ccdc77 Nemp1 Nemp1 Skint5 Skint5 Mafk Mafk Cep85 Cep85 Ccdc34 Ccdc34 Depdc1b Depdc1b
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Ubald2UBA-like domain-containing protein 2; Belongs to the UBALD family. (164 aa)    
Predicted Functional Partners:
Ccdc150
Coiled-coil domain-containing protein 150.
      
 0.586
Edem2
ER degradation-enhancing alpha-mannosidase-like protein 2; Involved in the endoplasmic reticulum-associated degradation (ERAD) pathway that targets misfolded glycoproteins for degradation in an N-glycan-dependent manner. May initiate ERAD by promoting the first mannose trimming step of ERAD substrates, from Man9GlcNAc2 to Man8GlcNAc2 (By similarity). Seems to recognize and bind to exposed hydrophobic regions in target proteins ; Belongs to the glycosyl hydrolase 47 family.
      
 0.580
Akirin2
Akirin-2; Forms a complex with YWHAB that acts to repress transcription of DUSP1 (By similarity). Required for embryonic development and the innate immune response. Downstream effector of the Toll-like receptor (TLR), TNF and IL-1 beta signaling pathways leading to the production of IL-6; Belongs to the akirin family.
   
  
 0.551
Ccdc77
Coiled-coil domain-containing protein 77.
      
 0.528
Nemp1
Nuclear envelope integral membrane protein 1.
   
  
 0.515
Skint5
Selection and upkeep of intraepithelial T-cells protein 5; May act by engaging a cell surface molecule on immature T- cells in the embryonic thymus.
      
 0.491
Mafk
Transcription factor MafK; Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves (By similarity). However, they act as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2, NFE2L1/NRF1, NFE2L2/NRF2 and NFE2L3/NRF3, and recruiting them to specific DNA-binding sites. Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor (By similarity).
   
  
 0.458
Cep85
Centrosomal protein of 85 kDa; Acts as a negative regulator of NEK2 to maintain the centrosome integrity in interphase. Suppresses centrosome disjunction by inhibiting NEK2 kinase activity; Belongs to the CEP85 family.
      
 0.457
Ccdc34
Coiled-coil domain-containing protein 34.
      
 0.453
Depdc1b
DEP domain-containing protein 1B.
   
  
 0.445
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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