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Cyp3a25 Cyp3a25 Ugt2a3 Ugt2a3 Cyp3a11 Cyp3a11 Ugt2b5 Ugt2b5 Cyp1a2 Cyp1a2 Ugt2b36 Ugt2b36 Rdh7 Rdh7 Cyp2c37 Cyp2c37 Cyp2c50 Cyp2c50 Ugt2b1 Ugt2b1 Cyp2e1 Cyp2e1
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Score
Cyp3a25Cytochrome P450 3A25; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (503 aa)    
Predicted Functional Partners:
Ugt2a3
UDP-glucuronosyltransferase 2A3; UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity); Belongs to the UDP-glycosyltransferase family.
   
 0.981
Cyp3a11
Cytochrome P450 3A11; Catalyzes erythromycin N-demethylation, nifedipine oxidation and testosterone 6 beta-hydroxylation; Belongs to the cytochrome P450 family.
  
 
0.970
Ugt2b5
UDP-glucuronosyltransferase 2B17; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.
   
 0.961
Cyp1a2
Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...]
  
 
0.957
Ugt2b36
UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.
   
 0.953
Rdh7
Retinol dehydrogenase 7; Acts on androgens and retinols, i.e. has steroid 3-alpha- and 17-beta-dehydrogenase and cis/trans-retinol catalytic activities.
   
  
 0.950
Cyp2c37
Cytochrome P450 2C37; Metabolizes arachidonic acid to produce 12- hydroxyeicosatetraenoic acid (HETE); Belongs to the cytochrome P450 family.
  
0.949
Cyp2c50
Cytochrome P450 2C50; Metabolizes arachidonic acid to several midchain and omega- terminal hydroxyeicosatetraenoic acids (HETE).
  
0.949
Ugt2b1
UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.
   
 0.948
Cyp2e1
Cytochrome P450 2E1; A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics.
  
 
0.946
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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