node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Adgrl1 | Bhlhb9 | ENSMUSP00000118452 | ENSMUSP00000068067 | Adhesion G protein-coupled receptor L1; Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity); Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily. | Protein BHLHb9; May play a role in the control of cellular aging and survival; Belongs to the GPRASP family. | 0.702 |
Adgrl1 | Flrt2 | ENSMUSP00000118452 | ENSMUSP00000062171 | Adhesion G protein-coupled receptor L1; Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity); Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily. | Leucine-rich repeat transmembrane protein FLRT2; Functions in cell-cell adhesion, cell migration and axon guidance. Mediates cell-cell adhesion via its interactions with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells. May play a role in the migration of cortical neurons during brain development via its interaction with UNC5D. Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5D, and possibly also other UNC-5 family members. Plays a role in fibroblast growth factor-mediated signal [...] | 0.854 |
Adgrl2 | Bhlhb9 | ENSMUSP00000143626 | ENSMUSP00000068067 | Adhesion G protein-coupled receptor L2; Calcium-independent receptor of low affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis. | Protein BHLHb9; May play a role in the control of cellular aging and survival; Belongs to the GPRASP family. | 0.628 |
Adgrl2 | Flrt2 | ENSMUSP00000143626 | ENSMUSP00000062171 | Adhesion G protein-coupled receptor L2; Calcium-independent receptor of low affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis. | Leucine-rich repeat transmembrane protein FLRT2; Functions in cell-cell adhesion, cell migration and axon guidance. Mediates cell-cell adhesion via its interactions with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells. May play a role in the migration of cortical neurons during brain development via its interaction with UNC5D. Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5D, and possibly also other UNC-5 family members. Plays a role in fibroblast growth factor-mediated signal [...] | 0.746 |
Adgrl3 | Bhlhb9 | ENSMUSP00000072336 | ENSMUSP00000068067 | Adhesion G protein-coupled receptor L3; Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells. Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex. | Protein BHLHb9; May play a role in the control of cellular aging and survival; Belongs to the GPRASP family. | 0.536 |
Adgrl3 | Flrt2 | ENSMUSP00000072336 | ENSMUSP00000062171 | Adhesion G protein-coupled receptor L3; Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells. Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex. | Leucine-rich repeat transmembrane protein FLRT2; Functions in cell-cell adhesion, cell migration and axon guidance. Mediates cell-cell adhesion via its interactions with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells. May play a role in the migration of cortical neurons during brain development via its interaction with UNC5D. Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5D, and possibly also other UNC-5 family members. Plays a role in fibroblast growth factor-mediated signal [...] | 0.913 |
Arxes2 | Bhlhb9 | ENSMUSP00000051250 | ENSMUSP00000068067 | Adipocyte-related X-chromosome expressed sequence 1; Plays a role in adipogenesis; Belongs to the SPCS3 family. | Protein BHLHb9; May play a role in the control of cellular aging and survival; Belongs to the GPRASP family. | 0.532 |
Arxes2 | Spcs3 | ENSMUSP00000051250 | ENSMUSP00000136527 | Adipocyte-related X-chromosome expressed sequence 1; Plays a role in adipogenesis; Belongs to the SPCS3 family. | Signal peptidase complex subunit 3; Component of the microsomal signal peptidase complex which removes signal peptides and other N-terminal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. | 0.901 |
Bhlhb9 | Adgrl1 | ENSMUSP00000068067 | ENSMUSP00000118452 | Protein BHLHb9; May play a role in the control of cellular aging and survival; Belongs to the GPRASP family. | Adhesion G protein-coupled receptor L1; Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity); Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily. | 0.702 |
Bhlhb9 | Adgrl2 | ENSMUSP00000068067 | ENSMUSP00000143626 | Protein BHLHb9; May play a role in the control of cellular aging and survival; Belongs to the GPRASP family. | Adhesion G protein-coupled receptor L2; Calcium-independent receptor of low affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis. | 0.628 |
Bhlhb9 | Adgrl3 | ENSMUSP00000068067 | ENSMUSP00000072336 | Protein BHLHb9; May play a role in the control of cellular aging and survival; Belongs to the GPRASP family. | Adhesion G protein-coupled receptor L3; Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells. Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex. | 0.536 |
Bhlhb9 | Arxes2 | ENSMUSP00000068067 | ENSMUSP00000051250 | Protein BHLHb9; May play a role in the control of cellular aging and survival; Belongs to the GPRASP family. | Adipocyte-related X-chromosome expressed sequence 1; Plays a role in adipogenesis; Belongs to the SPCS3 family. | 0.532 |
Bhlhb9 | Dixdc1 | ENSMUSP00000068067 | ENSMUSP00000034566 | Protein BHLHb9; May play a role in the control of cellular aging and survival; Belongs to the GPRASP family. | Dixin; Positive effector of the Wnt signaling pathway; activates WNT3A signaling via DVL2. Regulates JNK activation by AXIN1 and DVL2. | 0.650 |
Bhlhb9 | Dstyk | ENSMUSP00000068067 | ENSMUSP00000035358 | Protein BHLHb9; May play a role in the control of cellular aging and survival; Belongs to the GPRASP family. | Dual serine/threonine and tyrosine protein kinase; Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation. Involved in the regulation of both caspase-dependent apoptosis and caspase- independent cell death. In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. | 0.470 |
Bhlhb9 | Flrt2 | ENSMUSP00000068067 | ENSMUSP00000062171 | Protein BHLHb9; May play a role in the control of cellular aging and survival; Belongs to the GPRASP family. | Leucine-rich repeat transmembrane protein FLRT2; Functions in cell-cell adhesion, cell migration and axon guidance. Mediates cell-cell adhesion via its interactions with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells. May play a role in the migration of cortical neurons during brain development via its interaction with UNC5D. Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5D, and possibly also other UNC-5 family members. Plays a role in fibroblast growth factor-mediated signal [...] | 0.473 |
Bhlhb9 | Spcs3 | ENSMUSP00000068067 | ENSMUSP00000136527 | Protein BHLHb9; May play a role in the control of cellular aging and survival; Belongs to the GPRASP family. | Signal peptidase complex subunit 3; Component of the microsomal signal peptidase complex which removes signal peptides and other N-terminal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. | 0.511 |
Bhlhb9 | Tmem104 | ENSMUSP00000068067 | ENSMUSP00000056805 | Protein BHLHb9; May play a role in the control of cellular aging and survival; Belongs to the GPRASP family. | Transmembrane protein 104. | 0.491 |
Bhlhb9 | Zc3h15 | ENSMUSP00000068067 | ENSMUSP00000080301 | Protein BHLHb9; May play a role in the control of cellular aging and survival; Belongs to the GPRASP family. | Zinc finger CCCH domain-containing protein 15; Protects DRG1 from proteolytic degradation. Stimulates DRG1 GTPase activity likely by increasing the affinity for the potassium ions (By similarity). | 0.538 |
Dixdc1 | Bhlhb9 | ENSMUSP00000034566 | ENSMUSP00000068067 | Dixin; Positive effector of the Wnt signaling pathway; activates WNT3A signaling via DVL2. Regulates JNK activation by AXIN1 and DVL2. | Protein BHLHb9; May play a role in the control of cellular aging and survival; Belongs to the GPRASP family. | 0.650 |
Dstyk | Bhlhb9 | ENSMUSP00000035358 | ENSMUSP00000068067 | Dual serine/threonine and tyrosine protein kinase; Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation. Involved in the regulation of both caspase-dependent apoptosis and caspase- independent cell death. In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. | Protein BHLHb9; May play a role in the control of cellular aging and survival; Belongs to the GPRASP family. | 0.470 |