Prp2 protein (mouse) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

Prp2

Proline-rich protein 2. (316 aa)

Predicted Functional Partners:

Sprn

0.551

Prnp

0.509

Olfr129

0.478

Olfr121

0.440

Sprr2d

0.432

Mrpl49

0.404

Mrps16

0.400

Your Current Organism:

Mus musculus

NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Mrpl49	Mrps16	ENSMUSP00000007482	ENSMUSP00000055619	39S ribosomal protein L49, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mL49 family.	28S ribosomal protein S16, mitochondrial; Belongs to the bacterial ribosomal protein bS16 family.	0.987
Mrpl49	Prp2	ENSMUSP00000007482	ENSMUSP00000075435	39S ribosomal protein L49, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mL49 family.	Proline-rich protein 2.	0.404
Mrps16	Mrpl49	ENSMUSP00000055619	ENSMUSP00000007482	28S ribosomal protein S16, mitochondrial; Belongs to the bacterial ribosomal protein bS16 family.	39S ribosomal protein L49, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mL49 family.	0.987
Mrps16	Prp2	ENSMUSP00000055619	ENSMUSP00000075435	28S ribosomal protein S16, mitochondrial; Belongs to the bacterial ribosomal protein bS16 family.	Proline-rich protein 2.	0.400
Olfr121	Prp2	ENSMUSP00000133865	ENSMUSP00000075435	Olfactory receptor.	Proline-rich protein 2.	0.440
Olfr129	Prp2	ENSMUSP00000149327	ENSMUSP00000075435	Olfactory receptor.	Proline-rich protein 2.	0.478
Prnp	Prp2	ENSMUSP00000088833	ENSMUSP00000075435	Major prion protein; Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase deg [...]	Proline-rich protein 2.	0.509
Prnp	Sprn	ENSMUSP00000088833	ENSMUSP00000053901	Major prion protein; Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase deg [...]	Shadow of prion protein; Prion-like protein that has PrP(C)-like neuroprotective activity. May act as a modulator for the biological actions of normal and abnormal PrP.	0.796
Prp2	Mrpl49	ENSMUSP00000075435	ENSMUSP00000007482	Proline-rich protein 2.	39S ribosomal protein L49, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mL49 family.	0.404
Prp2	Mrps16	ENSMUSP00000075435	ENSMUSP00000055619	Proline-rich protein 2.	28S ribosomal protein S16, mitochondrial; Belongs to the bacterial ribosomal protein bS16 family.	0.400
Prp2	Olfr121	ENSMUSP00000075435	ENSMUSP00000133865	Proline-rich protein 2.	Olfactory receptor.	0.440
Prp2	Olfr129	ENSMUSP00000075435	ENSMUSP00000149327	Proline-rich protein 2.	Olfactory receptor.	0.478
Prp2	Prnp	ENSMUSP00000075435	ENSMUSP00000088833	Proline-rich protein 2.	Major prion protein; Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase deg [...]	0.509
Prp2	Sprn	ENSMUSP00000075435	ENSMUSP00000053901	Proline-rich protein 2.	Shadow of prion protein; Prion-like protein that has PrP(C)-like neuroprotective activity. May act as a modulator for the biological actions of normal and abnormal PrP.	0.551
Prp2	Sprr2d	ENSMUSP00000075435	ENSMUSP00000039821	Proline-rich protein 2.	Small proline-rich protein 2D; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane (By similarity).	0.432
Sprn	Prnp	ENSMUSP00000053901	ENSMUSP00000088833	Shadow of prion protein; Prion-like protein that has PrP(C)-like neuroprotective activity. May act as a modulator for the biological actions of normal and abnormal PrP.	Major prion protein; Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase deg [...]	0.796
Sprn	Prp2	ENSMUSP00000053901	ENSMUSP00000075435	Shadow of prion protein; Prion-like protein that has PrP(C)-like neuroprotective activity. May act as a modulator for the biological actions of normal and abnormal PrP.	Proline-rich protein 2.	0.551
Sprr2d	Prp2	ENSMUSP00000039821	ENSMUSP00000075435	Small proline-rich protein 2D; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane (By similarity).	Proline-rich protein 2.	0.432