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Scoc Scoc Arl1 Arl1 Fez2 Fez2 Fez1 Fez1 Wac Wac Kcnt2 Kcnt2 Pqlc1 Pqlc1 Arfrp1 Arfrp1 Arl3 Arl3 Prpf38b Prpf38b Ttc12 Ttc12
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
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[Homology]
Score
ScocShort coiled-coil protein; Positive regulator of amino acid starvation-induced autophagy; Belongs to the SCOC family. (125 aa)    
Predicted Functional Partners:
Arl1
ADP-ribosylation factor-like protein 1; GTP-binding protein. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus (By similarity).
   
 
 0.860
Fez2
Fasciculation and elongation protein zeta-2; Involved in axonal outgrowth and fasciculation. Belongs to the zygin family.
   
 
 0.838
Fez1
Fasciculation and elongation protein zeta-1; May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. May participate in the transport of mitochondria and other cargos along microtubules (By similarity).
   
 
 0.776
Wac
WW domain-containing adapter protein with coiled-coil; Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1). Interacts with the RNA polymerase II transcriptional machinery via its WW domain and with RNF20-RNF40 via its coiled coil region, thereby linking and regulating H2BK120ub1 and gene transcription. Regulates the cell-cycle checkpoint activation in response to DNA damage. Positive regulator of amino acid starvation-induced autophagy. Also acts as a negative regulator of basal autophagy. Positively regulates MTOR activity by promot [...]
   
  
 0.738
Kcnt2
Potassium channel, subfamily T, member 2.
      
 0.661
Pqlc1
Solute carrier family 66 member 2.
      
 0.633
Arfrp1
ADP-ribosylation factor-related protein 1; Trans-Golgi-associated GTPase that regulates protein sorting. Controls the targeting of ARL1 and its effector to the trans-Golgi. Required for the lipidation of chylomicrons in the intestine and required for VLDL lipidation in the liver. Belongs to the small GTPase superfamily. Arf family.
      
 0.620
Arl3
ADP-ribosylation factor-like protein 3; Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase- activating proteins (GAP). Required for normal cytokinesis and cilia signaling. Required for targeting proteins to the cilium, including myristoylated NPHP3 and prenylated INPP5E. Targets NPHP3 to the ciliary membrane by releasing myristoylated NPHP3 from UNC119B cargo adapter into the cilium (By similarity). Requires assistance from GTPase-activating prote [...]
   
  
 0.614
Prpf38b
Pre-mRNA-splicing factor 38B; May be required for pre-mRNA splicing; Belongs to the PRP38 family.
      
 0.572
Ttc12
Tetratricopeptide repeat protein 12.
      
 0.566
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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