node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Dock7 | Kctd20 | ENSMUSP00000030286 | ENSMUSP00000156936 | Dedicator of cytokinesis protein 7; Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization (By similarity). As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton (By similarity). Has a role in pigmentation. Involved in the regulation of cortical neurogenesis through the control of rad [...] | BTB/POZ domain-containing protein KCTD20; Promotes the phosphorylation of AKT family members. | 0.512 |
Dock7 | Mtcl1 | ENSMUSP00000030286 | ENSMUSP00000083899 | Dedicator of cytokinesis protein 7; Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization (By similarity). As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton (By similarity). Has a role in pigmentation. Involved in the regulation of cortical neurogenesis through the control of rad [...] | Microtubule cross-linking factor 1; Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation. Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells. Belongs to the SOGA family. | 0.492 |
Dock7 | Pnma1 | ENSMUSP00000030286 | ENSMUSP00000060783 | Dedicator of cytokinesis protein 7; Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization (By similarity). As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton (By similarity). Has a role in pigmentation. Involved in the regulation of cortical neurogenesis through the control of rad [...] | Paraneoplastic antigen Ma1 homolog; Belongs to the PNMA family. | 0.501 |
Dock7 | Pnma2 | ENSMUSP00000030286 | ENSMUSP00000086646 | Dedicator of cytokinesis protein 7; Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization (By similarity). As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton (By similarity). Has a role in pigmentation. Involved in the regulation of cortical neurogenesis through the control of rad [...] | Paraneoplastic antigen Ma2 homolog; Belongs to the PNMA family. | 0.504 |
Dock7 | Ppp2r1a | ENSMUSP00000030286 | ENSMUSP00000007708 | Dedicator of cytokinesis protein 7; Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization (By similarity). As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton (By similarity). Has a role in pigmentation. Involved in the regulation of cortical neurogenesis through the control of rad [...] | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform; The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Upon interaction with GNA12 promotes dephosphorylation of microtubule associated protein TAU/MAPT (By similarity). Required for proper chromosome segregation and for centromeric localization of SGO1 in mitosis (By similarity). | 0.474 |
Dock7 | Ywhab | ENSMUSP00000030286 | ENSMUSP00000018470 | Dedicator of cytokinesis protein 7; Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization (By similarity). As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton (By similarity). Has a role in pigmentation. Involved in the regulation of cortical neurogenesis through the control of rad [...] | 14-3-3 protein beta/alpha, N-terminally processed; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by [...] | 0.476 |
Kctd20 | Dock7 | ENSMUSP00000156936 | ENSMUSP00000030286 | BTB/POZ domain-containing protein KCTD20; Promotes the phosphorylation of AKT family members. | Dedicator of cytokinesis protein 7; Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization (By similarity). As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton (By similarity). Has a role in pigmentation. Involved in the regulation of cortical neurogenesis through the control of rad [...] | 0.512 |
Kctd20 | Mtcl1 | ENSMUSP00000156936 | ENSMUSP00000083899 | BTB/POZ domain-containing protein KCTD20; Promotes the phosphorylation of AKT family members. | Microtubule cross-linking factor 1; Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation. Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells. Belongs to the SOGA family. | 0.606 |
Kctd20 | Pnma1 | ENSMUSP00000156936 | ENSMUSP00000060783 | BTB/POZ domain-containing protein KCTD20; Promotes the phosphorylation of AKT family members. | Paraneoplastic antigen Ma1 homolog; Belongs to the PNMA family. | 0.618 |
Kctd20 | Pnma2 | ENSMUSP00000156936 | ENSMUSP00000086646 | BTB/POZ domain-containing protein KCTD20; Promotes the phosphorylation of AKT family members. | Paraneoplastic antigen Ma2 homolog; Belongs to the PNMA family. | 0.635 |
Kctd20 | Ppp2r1a | ENSMUSP00000156936 | ENSMUSP00000007708 | BTB/POZ domain-containing protein KCTD20; Promotes the phosphorylation of AKT family members. | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform; The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Upon interaction with GNA12 promotes dephosphorylation of microtubule associated protein TAU/MAPT (By similarity). Required for proper chromosome segregation and for centromeric localization of SGO1 in mitosis (By similarity). | 0.528 |
Kctd20 | Ywhab | ENSMUSP00000156936 | ENSMUSP00000018470 | BTB/POZ domain-containing protein KCTD20; Promotes the phosphorylation of AKT family members. | 14-3-3 protein beta/alpha, N-terminally processed; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by [...] | 0.530 |
Lrrc45 | Megf6 | ENSMUSP00000026139 | ENSMUSP00000030897 | Leucine-rich repeat-containing protein 45; Component of the proteinaceous fiber-like linker between two centrioles, required for centrosome cohesion. | Multiple epidermal growth factor-like domains protein 6. | 0.452 |
Lrrc45 | Mtcl1 | ENSMUSP00000026139 | ENSMUSP00000083899 | Leucine-rich repeat-containing protein 45; Component of the proteinaceous fiber-like linker between two centrioles, required for centrosome cohesion. | Microtubule cross-linking factor 1; Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation. Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells. Belongs to the SOGA family. | 0.532 |
Megf6 | Lrrc45 | ENSMUSP00000030897 | ENSMUSP00000026139 | Multiple epidermal growth factor-like domains protein 6. | Leucine-rich repeat-containing protein 45; Component of the proteinaceous fiber-like linker between two centrioles, required for centrosome cohesion. | 0.452 |
Megf6 | Mtcl1 | ENSMUSP00000030897 | ENSMUSP00000083899 | Multiple epidermal growth factor-like domains protein 6. | Microtubule cross-linking factor 1; Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation. Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells. Belongs to the SOGA family. | 0.538 |
Mtcl1 | Dock7 | ENSMUSP00000083899 | ENSMUSP00000030286 | Microtubule cross-linking factor 1; Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation. Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells. Belongs to the SOGA family. | Dedicator of cytokinesis protein 7; Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization (By similarity). As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton (By similarity). Has a role in pigmentation. Involved in the regulation of cortical neurogenesis through the control of rad [...] | 0.492 |
Mtcl1 | Kctd20 | ENSMUSP00000083899 | ENSMUSP00000156936 | Microtubule cross-linking factor 1; Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation. Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells. Belongs to the SOGA family. | BTB/POZ domain-containing protein KCTD20; Promotes the phosphorylation of AKT family members. | 0.606 |
Mtcl1 | Lrrc45 | ENSMUSP00000083899 | ENSMUSP00000026139 | Microtubule cross-linking factor 1; Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation. Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells. Belongs to the SOGA family. | Leucine-rich repeat-containing protein 45; Component of the proteinaceous fiber-like linker between two centrioles, required for centrosome cohesion. | 0.532 |
Mtcl1 | Megf6 | ENSMUSP00000083899 | ENSMUSP00000030897 | Microtubule cross-linking factor 1; Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation. Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells. Belongs to the SOGA family. | Multiple epidermal growth factor-like domains protein 6. | 0.538 |