STRINGSTRING
Reg3a Reg3a Reg3b Reg3b Reg3d Reg3d Prss2 Prss2 Reg2 Reg2 Defa5 Defa5 Prss1 Prss1 Reg3g Reg3g Pnliprp2 Pnliprp2 Try5 Try5 Prss3 Prss3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
Reg3aRegenerating islet-derived protein 3-alpha 16.5 kDa form; Bactericidal C-type lectin (By similarity). Regulates keratinocyte proliferation and differentiation after skin injury via activation of EXTL3-PI3K-AKT signaling pathway. (175 aa)    
Predicted Functional Partners:
Reg3b
Regenerating islet-derived protein 3-beta 16.5 kDa form; Bactericidal C-type lectin which acts against several intestinal Gram-positive and Gram-negative bacteria. Lacks antibacterial activity against S.typhimurium. May play a role in protection against infection with S.enteritidis by inhibiting its translocation from the gut lumen into intestinal tissues and further extraintestinal tissues.
  
 
0.891
Reg3d
Regenerating islet-derived 3 delta.
  
 
0.788
Prss2
Anionic trypsin-2.
   
 0.667
Reg2
Lithostathine-2; Might act as an inhibitor of spontaneous calcium carbonate precipitation.
   
  
0.649
Defa5
Alpha-defensin 5.
   
  
 0.612
Prss1
Protease, serine, 1 (Trypsin 1); Belongs to the peptidase S1 family.
   
 0.573
Reg3g
Regenerating islet-derived protein 3-gamma 16.5 kDa form; Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Restricts bacterial colonization of the intestinal epithelial surface and consequently limits activation of adaptive immune responses by the microbiota. The uncleaved form has bacteriostatic activity, whereas the cleaved form has bactericidal activity against L.monocytogenes and methicillin-resistant S.aureus. Regulates keratinocyte proliferation and [...]
  
 
0.573
Pnliprp2
Pancreatic lipase-related protein 2; Lipase with broad substrate specificity. Can hydrolyze both phospholipids and galactolipids. Acts preferentially on monoglycerides, phospholipids and galactolipids. Contributes to milk fat hydrolysis (By similarity); Belongs to the AB hydrolase superfamily. Lipase family.
   
 
 0.562
Try5
Trypsinogen 9; Belongs to the peptidase S1 family.
   
 0.542
Prss3
Protease, serine 3; Belongs to the peptidase S1 family.
   
 0.532
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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