node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cs | Csl | ENSMUSP00000005826 | ENSMUSP00000052373 | Citrate synthase, mitochondrial; Belongs to the citrate synthase family. | Citrate synthase; Belongs to the citrate synthase family. | 0.906 |
Cs | Fh1 | ENSMUSP00000005826 | ENSMUSP00000027810 | Citrate synthase, mitochondrial; Belongs to the citrate synthase family. | Fumarate hydratase, mitochondrial; Catalyzes the reversible stereospecific interconversion of fumarate to L-malate. Experiments in different species have demonstrated that specific isoforms of this protein act in defined pathways and favor one direction over the other (Probable). [Isoform Cytoplasmic]: Catalyzes the dehydration of L-malate to fumarate. Fumarate metabolism in the cytosol plays a role during urea cycle and arginine metabolism; fumarate being a by- product of the urea cycle and amino-acid catabolism. Also plays a role in DNA repair by promoting non-homologous end-joining [...] | 0.977 |
Cs | Got1 | ENSMUSP00000005826 | ENSMUSP00000026196 | Citrate synthase, mitochondrial; Belongs to the citrate synthase family. | Aspartate aminotransferase, cytoplasmic; Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-m [...] | 0.901 |
Cs | Got2 | ENSMUSP00000005826 | ENSMUSP00000034097 | Citrate synthase, mitochondrial; Belongs to the citrate synthase family. | Aspartate aminotransferase, mitochondrial; Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids. | 0.948 |
Cs | Mdh1 | ENSMUSP00000005826 | ENSMUSP00000099938 | Citrate synthase, mitochondrial; Belongs to the citrate synthase family. | Malate dehydrogenase, cytoplasmic. | 0.978 |
Cs | Mdh2 | ENSMUSP00000005826 | ENSMUSP00000019323 | Citrate synthase, mitochondrial; Belongs to the citrate synthase family. | Malate dehydrogenase, mitochondrial. | 0.996 |
Cs | Me1 | ENSMUSP00000005826 | ENSMUSP00000034989 | Citrate synthase, mitochondrial; Belongs to the citrate synthase family. | NADP-dependent malic enzyme. | 0.908 |
Cs | Me2 | ENSMUSP00000005826 | ENSMUSP00000025439 | Citrate synthase, mitochondrial; Belongs to the citrate synthase family. | NAD-dependent malic enzyme, mitochondrial. | 0.883 |
Cs | Me3 | ENSMUSP00000005826 | ENSMUSP00000032856 | Citrate synthase, mitochondrial; Belongs to the citrate synthase family. | NADP-dependent malic enzyme, mitochondrial; Belongs to the malic enzymes family. | 0.859 |
Cs | Pcx | ENSMUSP00000005826 | ENSMUSP00000063825 | Citrate synthase, mitochondrial; Belongs to the citrate synthase family. | Pyruvate carboxylase, mitochondrial; Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate. | 0.984 |
Csl | Cs | ENSMUSP00000052373 | ENSMUSP00000005826 | Citrate synthase; Belongs to the citrate synthase family. | Citrate synthase, mitochondrial; Belongs to the citrate synthase family. | 0.906 |
Csl | Fh1 | ENSMUSP00000052373 | ENSMUSP00000027810 | Citrate synthase; Belongs to the citrate synthase family. | Fumarate hydratase, mitochondrial; Catalyzes the reversible stereospecific interconversion of fumarate to L-malate. Experiments in different species have demonstrated that specific isoforms of this protein act in defined pathways and favor one direction over the other (Probable). [Isoform Cytoplasmic]: Catalyzes the dehydration of L-malate to fumarate. Fumarate metabolism in the cytosol plays a role during urea cycle and arginine metabolism; fumarate being a by- product of the urea cycle and amino-acid catabolism. Also plays a role in DNA repair by promoting non-homologous end-joining [...] | 0.972 |
Csl | Got1 | ENSMUSP00000052373 | ENSMUSP00000026196 | Citrate synthase; Belongs to the citrate synthase family. | Aspartate aminotransferase, cytoplasmic; Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-m [...] | 0.899 |
Csl | Got2 | ENSMUSP00000052373 | ENSMUSP00000034097 | Citrate synthase; Belongs to the citrate synthase family. | Aspartate aminotransferase, mitochondrial; Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids. | 0.938 |
Csl | Mdh1 | ENSMUSP00000052373 | ENSMUSP00000099938 | Citrate synthase; Belongs to the citrate synthase family. | Malate dehydrogenase, cytoplasmic. | 0.975 |
Csl | Mdh2 | ENSMUSP00000052373 | ENSMUSP00000019323 | Citrate synthase; Belongs to the citrate synthase family. | Malate dehydrogenase, mitochondrial. | 0.988 |
Csl | Me1 | ENSMUSP00000052373 | ENSMUSP00000034989 | Citrate synthase; Belongs to the citrate synthase family. | NADP-dependent malic enzyme. | 0.897 |
Csl | Me2 | ENSMUSP00000052373 | ENSMUSP00000025439 | Citrate synthase; Belongs to the citrate synthase family. | NAD-dependent malic enzyme, mitochondrial. | 0.882 |
Csl | Me3 | ENSMUSP00000052373 | ENSMUSP00000032856 | Citrate synthase; Belongs to the citrate synthase family. | NADP-dependent malic enzyme, mitochondrial; Belongs to the malic enzymes family. | 0.859 |
Csl | Pcx | ENSMUSP00000052373 | ENSMUSP00000063825 | Citrate synthase; Belongs to the citrate synthase family. | Pyruvate carboxylase, mitochondrial; Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate. | 0.984 |