node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AW549877 | Zmym4 | ENSMUSP00000038476 | ENSMUSP00000101714 | UPF0600 protein C5orf51 homolog. | Zinc finger MYM-type protein 4; Plays a role in the regulation of cell morphology and cytoskeletal organization. | 0.529 |
Atf7ip | Zmym2 | ENSMUSP00000032335 | ENSMUSP00000022511 | Activating transcription factor 7-interacting protein 1; Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Required for HUSH-mediated heterochromatin formation and gene silencing (By similarity). Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. Stabilizes SETDB1, is required to stimulate histone methyltransferase activity of SETDB1 and facilitates the conversio [...] | Zinc finger MYM-type protein 2; May function as a transcription factor. | 0.430 |
Atf7ip | Zmym4 | ENSMUSP00000032335 | ENSMUSP00000101714 | Activating transcription factor 7-interacting protein 1; Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Required for HUSH-mediated heterochromatin formation and gene silencing (By similarity). Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. Stabilizes SETDB1, is required to stimulate histone methyltransferase activity of SETDB1 and facilitates the conversio [...] | Zinc finger MYM-type protein 4; Plays a role in the regulation of cell morphology and cytoskeletal organization. | 0.527 |
Mib1 | Zmym4 | ENSMUSP00000054428 | ENSMUSP00000101714 | E3 ubiquitin-protein ligase MIB1; E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits primary cilium formation in proliferating cells. Mediates 'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation (By similarity). Probably mediates [...] | Zinc finger MYM-type protein 4; Plays a role in the regulation of cell morphology and cytoskeletal organization. | 0.585 |
Otud3 | Sgsm3 | ENSMUSP00000095441 | ENSMUSP00000122543 | OTU domain-containing protein 3; Deubiquitinating enzyme that hydrolyzes 'Lys-6'- and 'Lys- 11'-linked polyubiquitin. Also hydrolyzes heterotypic (mixed and branched) and homotypic chains (By similarity). | Small G protein signaling modulator 3; May play a cooperative role in NF2-mediated growth suppression of cells. | 0.544 |
Otud3 | Ufsp2 | ENSMUSP00000095441 | ENSMUSP00000034051 | OTU domain-containing protein 3; Deubiquitinating enzyme that hydrolyzes 'Lys-6'- and 'Lys- 11'-linked polyubiquitin. Also hydrolyzes heterotypic (mixed and branched) and homotypic chains (By similarity). | Ufm1-specific protease 2; Thiol protease which recognizes and hydrolyzes the peptide bond at the C-terminal Gly of UFM1, a ubiquitin-like modifier protein bound to a number of target proteins. Does not hydrolyze SUMO1 or ISG15 ubiquitin-like proteins. Through TRIP4 deufmylation may regulate intracellular nuclear receptors transactivation and thereby regulate cell proliferation and differentiation (By similarity); Belongs to the peptidase C78 family. | 0.501 |
Otud3 | Zmym4 | ENSMUSP00000095441 | ENSMUSP00000101714 | OTU domain-containing protein 3; Deubiquitinating enzyme that hydrolyzes 'Lys-6'- and 'Lys- 11'-linked polyubiquitin. Also hydrolyzes heterotypic (mixed and branched) and homotypic chains (By similarity). | Zinc finger MYM-type protein 4; Plays a role in the regulation of cell morphology and cytoskeletal organization. | 0.543 |
Phip | Zmym4 | ENSMUSP00000034787 | ENSMUSP00000101714 | PH-interacting protein; Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an anti-apoptotic activity through AKT1 phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization. | Zinc finger MYM-type protein 4; Plays a role in the regulation of cell morphology and cytoskeletal organization. | 0.592 |
Rnaseh2b | Zmym4 | ENSMUSP00000022499 | ENSMUSP00000101714 | Ribonuclease H2 subunit B; Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes. | Zinc finger MYM-type protein 4; Plays a role in the regulation of cell morphology and cytoskeletal organization. | 0.547 |
Sgsm3 | Otud3 | ENSMUSP00000122543 | ENSMUSP00000095441 | Small G protein signaling modulator 3; May play a cooperative role in NF2-mediated growth suppression of cells. | OTU domain-containing protein 3; Deubiquitinating enzyme that hydrolyzes 'Lys-6'- and 'Lys- 11'-linked polyubiquitin. Also hydrolyzes heterotypic (mixed and branched) and homotypic chains (By similarity). | 0.544 |
Sgsm3 | Ufsp2 | ENSMUSP00000122543 | ENSMUSP00000034051 | Small G protein signaling modulator 3; May play a cooperative role in NF2-mediated growth suppression of cells. | Ufm1-specific protease 2; Thiol protease which recognizes and hydrolyzes the peptide bond at the C-terminal Gly of UFM1, a ubiquitin-like modifier protein bound to a number of target proteins. Does not hydrolyze SUMO1 or ISG15 ubiquitin-like proteins. Through TRIP4 deufmylation may regulate intracellular nuclear receptors transactivation and thereby regulate cell proliferation and differentiation (By similarity); Belongs to the peptidase C78 family. | 0.519 |
Sgsm3 | Zmym4 | ENSMUSP00000122543 | ENSMUSP00000101714 | Small G protein signaling modulator 3; May play a cooperative role in NF2-mediated growth suppression of cells. | Zinc finger MYM-type protein 4; Plays a role in the regulation of cell morphology and cytoskeletal organization. | 0.582 |
Trim33 | Zmym2 | ENSMUSP00000029444 | ENSMUSP00000022511 | E3 ubiquitin-protein ligase TRIM33; Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway (By similarity). May act as a transcriptional repressor (By similarity). Inhibits the transcriptional response to TGF-beta/BMP signaling cascade (By similarity). Plays a role in the control of cell proliferation (By similarity). Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor. Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/ [...] | Zinc finger MYM-type protein 2; May function as a transcription factor. | 0.423 |
Trim33 | Zmym4 | ENSMUSP00000029444 | ENSMUSP00000101714 | E3 ubiquitin-protein ligase TRIM33; Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway (By similarity). May act as a transcriptional repressor (By similarity). Inhibits the transcriptional response to TGF-beta/BMP signaling cascade (By similarity). Plays a role in the control of cell proliferation (By similarity). Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor. Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/ [...] | Zinc finger MYM-type protein 4; Plays a role in the regulation of cell morphology and cytoskeletal organization. | 0.559 |
Ufsp2 | Otud3 | ENSMUSP00000034051 | ENSMUSP00000095441 | Ufm1-specific protease 2; Thiol protease which recognizes and hydrolyzes the peptide bond at the C-terminal Gly of UFM1, a ubiquitin-like modifier protein bound to a number of target proteins. Does not hydrolyze SUMO1 or ISG15 ubiquitin-like proteins. Through TRIP4 deufmylation may regulate intracellular nuclear receptors transactivation and thereby regulate cell proliferation and differentiation (By similarity); Belongs to the peptidase C78 family. | OTU domain-containing protein 3; Deubiquitinating enzyme that hydrolyzes 'Lys-6'- and 'Lys- 11'-linked polyubiquitin. Also hydrolyzes heterotypic (mixed and branched) and homotypic chains (By similarity). | 0.501 |
Ufsp2 | Sgsm3 | ENSMUSP00000034051 | ENSMUSP00000122543 | Ufm1-specific protease 2; Thiol protease which recognizes and hydrolyzes the peptide bond at the C-terminal Gly of UFM1, a ubiquitin-like modifier protein bound to a number of target proteins. Does not hydrolyze SUMO1 or ISG15 ubiquitin-like proteins. Through TRIP4 deufmylation may regulate intracellular nuclear receptors transactivation and thereby regulate cell proliferation and differentiation (By similarity); Belongs to the peptidase C78 family. | Small G protein signaling modulator 3; May play a cooperative role in NF2-mediated growth suppression of cells. | 0.519 |
Ufsp2 | Zmym4 | ENSMUSP00000034051 | ENSMUSP00000101714 | Ufm1-specific protease 2; Thiol protease which recognizes and hydrolyzes the peptide bond at the C-terminal Gly of UFM1, a ubiquitin-like modifier protein bound to a number of target proteins. Does not hydrolyze SUMO1 or ISG15 ubiquitin-like proteins. Through TRIP4 deufmylation may regulate intracellular nuclear receptors transactivation and thereby regulate cell proliferation and differentiation (By similarity); Belongs to the peptidase C78 family. | Zinc finger MYM-type protein 4; Plays a role in the regulation of cell morphology and cytoskeletal organization. | 0.545 |
Zmym2 | Atf7ip | ENSMUSP00000022511 | ENSMUSP00000032335 | Zinc finger MYM-type protein 2; May function as a transcription factor. | Activating transcription factor 7-interacting protein 1; Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Required for HUSH-mediated heterochromatin formation and gene silencing (By similarity). Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. Stabilizes SETDB1, is required to stimulate histone methyltransferase activity of SETDB1 and facilitates the conversio [...] | 0.430 |
Zmym2 | Trim33 | ENSMUSP00000022511 | ENSMUSP00000029444 | Zinc finger MYM-type protein 2; May function as a transcription factor. | E3 ubiquitin-protein ligase TRIM33; Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway (By similarity). May act as a transcriptional repressor (By similarity). Inhibits the transcriptional response to TGF-beta/BMP signaling cascade (By similarity). Plays a role in the control of cell proliferation (By similarity). Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor. Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/ [...] | 0.423 |
Zmym2 | Zmym4 | ENSMUSP00000022511 | ENSMUSP00000101714 | Zinc finger MYM-type protein 2; May function as a transcription factor. | Zinc finger MYM-type protein 4; Plays a role in the regulation of cell morphology and cytoskeletal organization. | 0.615 |