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Mdh1b Mdh1b Ttc16 Ttc16 Idh2 Idh2 Eno4 Eno4 Idh1 Idh1 Suclg1 Suclg1 Cs Cs Csl Csl Pklr Pklr Dynlrb2 Dynlrb2 Nme5 Nme5
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Mdh1bPutative malate dehydrogenase 1B; Belongs to the LDH/MDH superfamily. MDH type 2 family. (500 aa)    
Predicted Functional Partners:
Ttc16
Tetratricopeptide repeat protein 16.
   
  
 0.751
Idh2
Isocitrate dehydrogenase [NADP], mitochondrial; Plays a role in intermediary metabolism and energy production. It may tightly associate or interact with the pyruvate dehydrogenase complex; Belongs to the isocitrate and isopropylmalate dehydrogenases family.
  
 
 0.676
Eno4
Enolase 4; Required for sperm motility, function and male fertility. May be involved in the normal assembly of the sperm fibrous sheath and provides most of the enolase activity in sperm.
  
 
 0.668
Idh1
Isocitrate dehydrogenase [NADP] cytoplasmic; Belongs to the isocitrate and isopropylmalate dehydrogenases family.
  
 
 0.657
Suclg1
Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.
  
 
 0.644
Cs
Citrate synthase, mitochondrial; Belongs to the citrate synthase family.
  
 
 0.642
Csl
Citrate synthase; Belongs to the citrate synthase family.
  
 
 0.642
Pklr
Pyruvate kinase PKLR; Plays a key role in glycolysis.
  
 
 0.625
Dynlrb2
Dynein light chain roadblock-type 2; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules; Belongs to the GAMAD family.
   
    0.609
Nme5
Nucleoside diphosphate kinase homolog 5; Does not seem to have NDK kinase activity. Confers protection from cell death by Bax and alters the cellular levels of several antioxidant enzymes including Gpx5. May play a role in spermiogenesis by increasing the ability of late-stage spermatids to eliminate reactive oxygen species.
  
 
 0.602
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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