STRINGSTRING
Comtd1 Comtd1 Dus2 Dus2 Map6d1 Map6d1 Coprs Coprs Paxbp1 Paxbp1 Mcrip2 Mcrip2 Tmc4 Tmc4 Disp2 Disp2 Rbm12b2 Rbm12b2 Podxl2 Podxl2 Mdn1 Mdn1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
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[Homology]
Score
Comtd1Catechol O-methyltransferase domain-containing protein 1; Putative O-methyltransferase. (262 aa)    
Predicted Functional Partners:
Dus2
tRNA-dihydrouridine(20) synthase [NAD(P)+]-like; Dihydrouridine synthase. Catalyzes the NADPH-dependent synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Negatively regulates the activation of EIF2AK2/PKR. Belongs to the Dus family. Dus2 subfamily.
   
  
 0.684
Map6d1
MAP6 domain-containing protein 1; May have microtubule-stabilizing activity.
    
 
 0.626
Coprs
Coordinator of PRMT5 and differentiation stimulator; Histone-binding protein required for histone H4 methyltransferase activity of PRMT5. Specifically required for histone H4 'Arg-3' methylation mediated by PRMT5, but not histone H3 'Arg-8' methylation, suggesting that it modulates the substrate specificity of PRMT5. Specifically interacts with the N-terminus of histone H4 but not with histone H3, suggesting that it acts by promoting the association between histone H4 and PRMT5. Involved in CCNE1 promoter repression (By similarity). Plays a role in muscle cell differentiation by modula [...]
   
  
 0.620
Paxbp1
PAX3- and PAX7-binding protein 1; Adapter protein linking the transcription factors PAX3 and PAX7 to the histone methylation machinery and involved in myogenesis. Associates with a histone methyltransferase complex that specifically mediates dimethylation and trimethylation of 'Lys-4' of histone H3. Mediates the recruitment of that complex to the transcription factors PAX3 and PAX7 on chromatin to regulate the expression of genes involved in muscle progenitor cells proliferation including ID3 and CDC20. Belongs to the GCF family.
      
 0.618
Mcrip2
MAPK regulated corepressor interacting protein 2; Belongs to the MCRIP family.
   
  
 0.613
Tmc4
Transmembrane channel-like protein 4; Probable ion channel; Belongs to the TMC family.
   
  
 0.605
Disp2
Protein dispatched homolog 2; Belongs to the dispatched family.
      
 0.526
Rbm12b2
RNA-binding protein 12B-B.
      
 0.516
Podxl2
Podocalyxin-like protein 2; Acts as a ligand for vascular selectins. Mediates rapid rolling of leukocytes over vascular surfaces through high affinity divalent cation-dependent interactions with E-, P- and L-selectins (By similarity); Belongs to the podocalyxin family.
   
  
 0.496
Mdn1
Midasin; Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits; Belongs to the midasin family.
      
 0.496
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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