node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Abcb7 | Alas2 | ENSRNOP00000003739 | ENSRNOP00000000180 | ATP-binding cassette sub-family B member 7, mitochondrial; Could be involved in the transport of heme from the mitochondria to the cytosol. Plays a central role in the maturation of cytosolic iron-sulfur (Fe/S) cluster-containing proteins. | 5-aminolevulinate synthase, erythroid-specific, mitochondrial. | 0.801 |
Abcb7 | Cpox | ENSRNOP00000003739 | ENSRNOP00000002257 | ATP-binding cassette sub-family B member 7, mitochondrial; Could be involved in the transport of heme from the mitochondria to the cytosol. Plays a central role in the maturation of cytosolic iron-sulfur (Fe/S) cluster-containing proteins. | Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX (By similarity). | 0.531 |
Abcb7 | Fech | ENSRNOP00000003739 | ENSRNOP00000024328 | ATP-binding cassette sub-family B member 7, mitochondrial; Could be involved in the transport of heme from the mitochondria to the cytosol. Plays a central role in the maturation of cytosolic iron-sulfur (Fe/S) cluster-containing proteins. | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. | 0.908 |
Abcb7 | Urod | ENSRNOP00000003739 | ENSRNOP00000024719 | ATP-binding cassette sub-family B member 7, mitochondrial; Could be involved in the transport of heme from the mitochondria to the cytosol. Plays a central role in the maturation of cytosolic iron-sulfur (Fe/S) cluster-containing proteins. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.470 |
Ahsp | Alas2 | ENSRNOP00000027297 | ENSRNOP00000000180 | Erythroid associated factor (Predicted). | 5-aminolevulinate synthase, erythroid-specific, mitochondrial. | 0.853 |
Ahsp | Fech | ENSRNOP00000027297 | ENSRNOP00000024328 | Erythroid associated factor (Predicted). | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. | 0.417 |
Ahsp | Gata1 | ENSRNOP00000027297 | ENSRNOP00000038111 | Erythroid associated factor (Predicted). | Erythroid transcription factor; Transcriptional activator or repressor which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of globin genes and of other genes expressed in erythroid cells. Activates the transcription of genes involved in erythroid differentiation of K562 erythroleukemia cells, including HBB, HBG1/2, ALAS2 and HMBS. | 0.685 |
Ahsp | LOC108348091 | ENSRNOP00000027297 | ENSRNOP00000067336 | Erythroid associated factor (Predicted). | GATA binding protein 1. | 0.673 |
Ahsp | Slc4a1 | ENSRNOP00000027297 | ENSRNOP00000028445 | Erythroid associated factor (Predicted). | Band 3 anion transport protein; Functions both as a transporter that mediates electroneutral anion exchange across the cell membrane and as a structural protein. Major integral membrane glycoprotein of the erythrocyte membrane; required for normal flexibility and stability of the erythrocyte membrane and for normal erythrocyte shape via the interactions of its cytoplasmic domain with cytoskeletal proteins, glycolytic enzymes, and hemoglobin. Functions as a transporter that mediates the 1:1 exchange of inorganic anions across the erythrocyte membrane. Mediates chloride- bicarbonate exch [...] | 0.760 |
Alad | Alas2 | ENSRNOP00000020625 | ENSRNOP00000000180 | Delta-aminolevulinic acid dehydratase; Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity); Belongs to the ALAD family. | 5-aminolevulinate synthase, erythroid-specific, mitochondrial. | 0.871 |
Alad | Cpox | ENSRNOP00000020625 | ENSRNOP00000002257 | Delta-aminolevulinic acid dehydratase; Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity); Belongs to the ALAD family. | Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX (By similarity). | 0.924 |
Alad | Fech | ENSRNOP00000020625 | ENSRNOP00000024328 | Delta-aminolevulinic acid dehydratase; Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity); Belongs to the ALAD family. | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. | 0.927 |
Alad | Gata1 | ENSRNOP00000020625 | ENSRNOP00000038111 | Delta-aminolevulinic acid dehydratase; Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity); Belongs to the ALAD family. | Erythroid transcription factor; Transcriptional activator or repressor which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of globin genes and of other genes expressed in erythroid cells. Activates the transcription of genes involved in erythroid differentiation of K562 erythroleukemia cells, including HBB, HBG1/2, ALAS2 and HMBS. | 0.407 |
Alad | Hmbs | ENSRNOP00000020625 | ENSRNOP00000014128 | Delta-aminolevulinic acid dehydratase; Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity); Belongs to the ALAD family. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. | 0.999 |
Alad | Urod | ENSRNOP00000020625 | ENSRNOP00000024719 | Delta-aminolevulinic acid dehydratase; Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity); Belongs to the ALAD family. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.950 |
Alas2 | Abcb7 | ENSRNOP00000000180 | ENSRNOP00000003739 | 5-aminolevulinate synthase, erythroid-specific, mitochondrial. | ATP-binding cassette sub-family B member 7, mitochondrial; Could be involved in the transport of heme from the mitochondria to the cytosol. Plays a central role in the maturation of cytosolic iron-sulfur (Fe/S) cluster-containing proteins. | 0.801 |
Alas2 | Ahsp | ENSRNOP00000000180 | ENSRNOP00000027297 | 5-aminolevulinate synthase, erythroid-specific, mitochondrial. | Erythroid associated factor (Predicted). | 0.853 |
Alas2 | Alad | ENSRNOP00000000180 | ENSRNOP00000020625 | 5-aminolevulinate synthase, erythroid-specific, mitochondrial. | Delta-aminolevulinic acid dehydratase; Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity); Belongs to the ALAD family. | 0.871 |
Alas2 | Cpox | ENSRNOP00000000180 | ENSRNOP00000002257 | 5-aminolevulinate synthase, erythroid-specific, mitochondrial. | Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX (By similarity). | 0.791 |
Alas2 | Fech | ENSRNOP00000000180 | ENSRNOP00000024328 | 5-aminolevulinate synthase, erythroid-specific, mitochondrial. | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. | 0.871 |