node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Acly | Cs | ENSRNOP00000023447 | ENSRNOP00000034921 | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | Citrate synthase, mitochondrial. | 0.998 |
Acly | Slc25a1 | ENSRNOP00000023447 | ENSRNOP00000000306 | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | Tricarboxylate transport protein, mitochondrial; Citrate transporter that mediates the exchange of mitochondrial citrate for cytosolic malate. Also able to mediate the exchange of citrate for isocitrate, phosphoenolpyruvate, cis- but not trans-aconitate and to a lesser extend maleate and succinate. Important for the bioenergetics of hepatic cells as it provides a carbon source for fatty acid and sterol biosyntheses, and NAD(+) for the glycolytic pathway. Required for proper neuromuscular junction formation. Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.856 |
Cs | Acly | ENSRNOP00000034921 | ENSRNOP00000023447 | Citrate synthase, mitochondrial. | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | 0.998 |
Cs | Drg1 | ENSRNOP00000034921 | ENSRNOP00000025241 | Citrate synthase, mitochondrial. | Developmentally-regulated GTP-binding protein 1. | 0.727 |
Cs | Grn | ENSRNOP00000034921 | ENSRNOP00000028557 | Citrate synthase, mitochondrial. | Paragranulin; Secreted protein that acts as a key regulator of lysosomal function and as a growth factor involved in inflammation, wound healing and cell proliferation (By similarity). Regulates protein trafficking to lysosomes and, also the activity of lysosomal enzymes (By similarity). Facilitates also the acidification of lysosomes, causing degradation of mature CTSD by CTSB (By similarity). In addition, functions as wound-related growth factor that acts directly on dermal fibroblasts and endothelial cells to promote division, migration and the formation of capillary-like tubule str [...] | 0.746 |
Cs | Pole2 | ENSRNOP00000034921 | ENSRNOP00000005835 | Citrate synthase, mitochondrial. | DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. | 0.727 |
Cs | RGD1305713 | ENSRNOP00000034921 | ENSRNOP00000070531 | Citrate synthase, mitochondrial. | UPF0235 protein C15orf40 homolog; Belongs to the UPF0235 family. | 0.727 |
Cs | RGD1564541 | ENSRNOP00000034921 | ENSRNOP00000016993 | Citrate synthase, mitochondrial. | Similar to hypothetical protein FLJ22965. | 0.727 |
Cs | Slc25a1 | ENSRNOP00000034921 | ENSRNOP00000000306 | Citrate synthase, mitochondrial. | Tricarboxylate transport protein, mitochondrial; Citrate transporter that mediates the exchange of mitochondrial citrate for cytosolic malate. Also able to mediate the exchange of citrate for isocitrate, phosphoenolpyruvate, cis- but not trans-aconitate and to a lesser extend maleate and succinate. Important for the bioenergetics of hepatic cells as it provides a carbon source for fatty acid and sterol biosyntheses, and NAD(+) for the glycolytic pathway. Required for proper neuromuscular junction formation. Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.956 |
Cs | Slc25a5 | ENSRNOP00000034921 | ENSRNOP00000015913 | Citrate synthase, mitochondrial. | ADP/ATP translocase 2, N-terminally processed; Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation (By similarity); Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.711 |
Drg1 | Cs | ENSRNOP00000025241 | ENSRNOP00000034921 | Developmentally-regulated GTP-binding protein 1. | Citrate synthase, mitochondrial. | 0.727 |
Drg1 | Grn | ENSRNOP00000025241 | ENSRNOP00000028557 | Developmentally-regulated GTP-binding protein 1. | Paragranulin; Secreted protein that acts as a key regulator of lysosomal function and as a growth factor involved in inflammation, wound healing and cell proliferation (By similarity). Regulates protein trafficking to lysosomes and, also the activity of lysosomal enzymes (By similarity). Facilitates also the acidification of lysosomes, causing degradation of mature CTSD by CTSB (By similarity). In addition, functions as wound-related growth factor that acts directly on dermal fibroblasts and endothelial cells to promote division, migration and the formation of capillary-like tubule str [...] | 0.727 |
Drg1 | Pole2 | ENSRNOP00000025241 | ENSRNOP00000005835 | Developmentally-regulated GTP-binding protein 1. | DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. | 0.740 |
Drg1 | RGD1305713 | ENSRNOP00000025241 | ENSRNOP00000070531 | Developmentally-regulated GTP-binding protein 1. | UPF0235 protein C15orf40 homolog; Belongs to the UPF0235 family. | 0.727 |
Drg1 | RGD1564541 | ENSRNOP00000025241 | ENSRNOP00000016993 | Developmentally-regulated GTP-binding protein 1. | Similar to hypothetical protein FLJ22965. | 0.737 |
Drg1 | Slc25a1 | ENSRNOP00000025241 | ENSRNOP00000000306 | Developmentally-regulated GTP-binding protein 1. | Tricarboxylate transport protein, mitochondrial; Citrate transporter that mediates the exchange of mitochondrial citrate for cytosolic malate. Also able to mediate the exchange of citrate for isocitrate, phosphoenolpyruvate, cis- but not trans-aconitate and to a lesser extend maleate and succinate. Important for the bioenergetics of hepatic cells as it provides a carbon source for fatty acid and sterol biosyntheses, and NAD(+) for the glycolytic pathway. Required for proper neuromuscular junction formation. Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.729 |
Drg1 | Slc25a5 | ENSRNOP00000025241 | ENSRNOP00000015913 | Developmentally-regulated GTP-binding protein 1. | ADP/ATP translocase 2, N-terminally processed; Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation (By similarity); Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.543 |
Grn | Cs | ENSRNOP00000028557 | ENSRNOP00000034921 | Paragranulin; Secreted protein that acts as a key regulator of lysosomal function and as a growth factor involved in inflammation, wound healing and cell proliferation (By similarity). Regulates protein trafficking to lysosomes and, also the activity of lysosomal enzymes (By similarity). Facilitates also the acidification of lysosomes, causing degradation of mature CTSD by CTSB (By similarity). In addition, functions as wound-related growth factor that acts directly on dermal fibroblasts and endothelial cells to promote division, migration and the formation of capillary-like tubule str [...] | Citrate synthase, mitochondrial. | 0.746 |
Grn | Drg1 | ENSRNOP00000028557 | ENSRNOP00000025241 | Paragranulin; Secreted protein that acts as a key regulator of lysosomal function and as a growth factor involved in inflammation, wound healing and cell proliferation (By similarity). Regulates protein trafficking to lysosomes and, also the activity of lysosomal enzymes (By similarity). Facilitates also the acidification of lysosomes, causing degradation of mature CTSD by CTSB (By similarity). In addition, functions as wound-related growth factor that acts directly on dermal fibroblasts and endothelial cells to promote division, migration and the formation of capillary-like tubule str [...] | Developmentally-regulated GTP-binding protein 1. | 0.727 |
Grn | Pole2 | ENSRNOP00000028557 | ENSRNOP00000005835 | Paragranulin; Secreted protein that acts as a key regulator of lysosomal function and as a growth factor involved in inflammation, wound healing and cell proliferation (By similarity). Regulates protein trafficking to lysosomes and, also the activity of lysosomal enzymes (By similarity). Facilitates also the acidification of lysosomes, causing degradation of mature CTSD by CTSB (By similarity). In addition, functions as wound-related growth factor that acts directly on dermal fibroblasts and endothelial cells to promote division, migration and the formation of capillary-like tubule str [...] | DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. | 0.727 |