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Serinc1 Serinc1 Rusc2 Rusc2 Bpifb6 Bpifb6 Ice2 Ice2 Atg9a Atg9a Cnot6l Cnot6l Sh3bgrl Sh3bgrl Ap4s1 Ap4s1 Pja2 Pja2 LOC500684 LOC500684 Fam160b1 Fam160b1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Serinc1Serine incorporator 1; Enhances the incorporation of serine into phosphatidylserine and sphingolipids. (453 aa)    
Predicted Functional Partners:
Rusc2
RUN and SH3 domain-containing 2.
   
  
 0.642
Bpifb6
Bactericidal/permeability-increasing protein-like 3 (Predicted).
      
 0.587
Ice2
Interactor of little elongation complex ELL subunit 2.
      
 0.553
Atg9a
Autophagy-related protein 9A; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Cycles between a juxta-nuclear trans-Golgi network compartment and late endosomes. Nutrient starvation induces accumulation on autophagosomes. Starvation-dependent trafficking requires ULK1, ATG13 and SUPT20H (By similarity).
      
 0.540
Cnot6l
CCR4-NOT transcription complex, subunit 6-like (Predicted).
   
  
 0.530
Sh3bgrl
SH3 domain-binding glutamic acid-rich-like protein; Belongs to the SH3BGR family.
   
  
 0.480
Ap4s1
AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.
   
  
 0.470
Pja2
E3 ubiquitin-protein ligase Praja-2; Has E2-dependent E3 ubiquitin-protein ligase activity. Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation. Essential for PKA-mediated long-term memory processes. Through the ubiquitination of MFHAS1, positively regulates the TLR2 signaling pathway that leads to the activation of the downstream p38 and JNK MAP kinases and promotes the polarization of macrophages toward the pro-inflammatory M1 phenotype.
   
  
 0.454
LOC500684
MI domain-containing protein.
      
 0.433
Fam160b1
Family with sequence similarity 160, member B1.
   
  
 0.416
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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